61 research outputs found
Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases
No full textA majority of current disease-modifying therapeutic
approaches for age-related neurodegenerative
diseases target their characteristic proteopathic
lesions (a-synuclein, Tau, Ab). To monitor such
treatments, fluid biomarkers reflecting the underlying
disease process are crucial. We found robust increases
of neurofilament light chain (NfL) in CSF
and blood in murine models of a-synucleinopathies,
tauopathy, and b-amyloidosis. Blood and CSF NfL
levels were strongly correlated, and NfL increases
coincided with the onset and progression of the
corresponding proteopathic lesions in brain. Experimental
induction of a-synuclein lesions increased
CSF and blood NfL levels, while blocking Ab lesions
attenuated the NfL increase. Consistently, we also
found NfL increases in CSF and blood of human
a-synucleinopathies, tauopathies, and Alzheimer’s
disease. Our results suggest that CSF and particularly
blood NfL can serve as a reliable and easily
accessible biomarker to monitor disease progression
and treatment response in mouse models and
potentially in human proteopathic neurodegenerative
diseases
A fuzzy MCDM framework based on fuzzy measure and fuzzy integral for agile supplier evaluation
No full textBi-Attempted Base Optimization Algorithm on Optimization of Hydrosystems
No full textThis study aims to search for optimum design parameters for a slurry pipeline problem and optimum operation parameters for a multi-reservoir scheduling problem by using Bi-Attempted Base Optimization Algorithm (ABaOA), which has been recently developed as a numerical bidirectional search algorithm. The slurry pipeline problem is a constrained non-linear cost minimization problem with constraints on facility capacities. It has two separate cost terms that behave differently with changes in decision variables. The problem includes several decision variables in addition to the fact that the objective function is highly non-linear. On the other hand, the multi-reservoir problem is a well-known problem in Hydraulics that aims to maximize benefit by optimizing the releases of each reservoir. The problem has a known global optimum, which is used to test the abilities of the ABaOA. The ABaOA is developed from Base Optimization Algorithm (BaOA) by transforming its operators with the aim to diversify the search paths to reach the global optimum. Its applications in hydrosystems show that it converges to the optimum solutions in reasonable times. The results from the first application are compared to the ones obtained from Genetic Algorithms (GA) application. It is observed that ABaOA outperformed GA in terms of speed of convergence and finding a better alternative solution. The ABaOA reaches the global optimum in the second application. In addition, alternatives with better benefit functions, including some penalties have been determined.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Rivers, Ports, Waterways and Dredging Engineerin
"Father" figure in Reşat Nuri Güntekin's novels "Acımak" and "Yaprak Dökümü"
No full textCumhuriyet Dönemi Türk edebiyatının unutulmaz isimlerinden biri olan Reşat Nuri Güntekin, üslubundaki akıcılık, teknik ve tahkiye ustalığının yanı sıra işlediği konularla da Türk halkının severek okuduğu sayısız esere imza atmış başarılı bir yazardır. Eserlerinde Anadolu'yu, Anadolu insanını tüm yönleriyle verirken döneminin sosyal yapısına, yaşanılan toplumsal değişime ve ferdî olduğu kadar toplumsal problemlere de ışık tutmuştur. Acımak ve Yaprak Dökümü adlı romanlar da yazarın bahsedilen özelliklerini taşıyan eserlerindendir. Yazar, gerek Acımak'ta gerekse Yaprak Dökümü'nde sosyal yaşamda var olma mücadelesi veren bireyi, bu bireyin toplumsal değişim karşısında yaşadığı zorlukları konu edinir. Her iki romanda da sorunlarla başa çıkmaya çalışan bir ?baba? motifi vardır ve iletilmek istenen mesaj iki farklı babanın hayat penceresinden sunulur. Bu çalışmada öncelikle Reşat Nuri Güntekin'in yaşamı, edebi kişiliği ve eserleri hakkında bilgi verilmiş, ilerleyen bölümlerde söz konusu romanlar incelenerek bu romanlarda yazarın ?baba? motifini nasıl ele aldığı problemi üzerinde durulmuştur. Bu bağlamda, yazar bu eserlerde baba ile ilgili hangi özellikleri ön plana çıkartmış, hangi amaçla bu baba karakterlerini yaratmış sorularının cevapları aranmaya çalışılmıştır.Resat Nuri Güntekin is an accomplished writer who is one of the reputable names in Turkish literature in the Republican era with his stylistic fluency, his mastery of the technical and narrative aspects, and has countless works read fondly by Turkish people. In his works he tried to give all aspects of Anatolia and Anatolian people, and also he shed light on social problems of the age as well as the social structure which experienced social and individual change. The author's novels named Yaprak Dökümü and Acımak bare the aforementioned features of his works. Both in Yaprak Dökümü and Acımak, the author narrates individuals who struggle to exist in social life and the adversaries of an individual in the face of social change. In each novel, there is a ?father? figure trying to cope with the problems and a message presented through the life views of these two different fathers. In this study, Resat Nuri Güntekin?s life, his literary identity and his works are presented initially, and in the following sections, the problem of the author?s use of the ?father? figure is focused on through the examination of these novels. Within this context, it has been tried to find out the answers to the questions of ?how the author deals with the ?father? figure in these works, what features of the father are emphasized, and for what purpose the father character was created?
Alî's İkâye-i Şâh Cihân and Gevher-Nigîn (Review-transcription text)
No full textSosyal Bilimler Enstitüsü, Türk Dili ve Edebiyatı Ana Bilim DalıKlasik Türk Edebiyatı manzum ağırlıklı bir edebiyattır. Bu alanda çeşitli konularda yazılmış pek çok eser bulunmaktadır. Mensur hikâye, bu alanda verilen manzum eserler kadar gün yüzüne çıkmamıştır. Ancak az da olsa mensur hikâye örneklerine rastlanılmaktadır. Yüksek lisans tezi olarak hazırlanan bu eser, mensur hikâye geleneğini içinde değerlendirilmiştir. Alî tarafından kaleme alınan "Alî'nin Hikâye-i Şâh Cihân ve Gevher-Nigîn'i" adlı bu eser, tek nüsha olup Almanya-Berlin Millî Kütüphanesi, Staatsbibliothek bölümü, Ms. Or. Fol. 4110 numarada kayıtlıdır. Metin 69 varaktan müteşekkil, harekesiz nesih hattıyla yazılmıştır. Metin içerisinde yer alan boş kısımların süsleme amacıyla boş bırakıldığı varsayılmaktadır. Eserin müellifi hakkında net bilgiye ulaşılamamıştır. Metin, giriş, eserin yazarı hakkında, eserin tahlili, dil ve anlatım özellikleri mitolojik ve efsanevi şahıslar, transkripsiyonlu metin ve sonuç kısmından oluşmaktadır. Eserin tahlili kısmı başlığı, konusu, temi ve tezi; olay örgüsü; motif yapısı; eserde zaman; eserde mekân; eserin şahıs kadrosu; eserin anlatım özellikleri ve eserde yer alan diğer unsurlar (hayvanlar, meslekler, musiki, kozmik âlem) geniş bir şekilde ele alınıp metinde örnekleriyle gösterilmiştir. Metinde incelenen özellikler tespit edilerek sonuç kısmında değerlendirilmesi yapılmıştır. "Alî'nin Hikâye-i Şâh Cihân ve Gevher-Nigîn'i" adlı bu eserin tahkiye esaslı metin olması, bünyesinde fazlaca şiirler bulundurması ve kaynağı itibarıyla Camasabname'nin hikâye örneklerinden birini teşkil etmesi bakımından önemlidir. Anahtar Kelimeler: Eski Türk Edebiyatı, "Alî'nin Hikâye-i Şâh Cihân ve Gevher-Nigîn'i", èAlî, mensur hikâye geleneğiClassical Turkish Literature is heavily based on verse. There are many works written in verse and in several different topics. Prosaic tales haven't come to light as much as verse. But even though there aren't much, examples of prosaic tales can be found. This work that is been written, can be included in the prosaic tale tradition. Written by Alî, "Alî'nin Hikâye-i Şâh Cihân" and "Gevher-Nigîn'i", consists of only one copy and is in the Staatsbibliothek section of the Berlin National Library and is registered in Ms. Or. Fol 4110. The text consists of 69 folios and is written in naskh lettering without vowel points. I am in the opinion that the empty sections of the text are left blank for decorative purposes. There have been found no definite information about the author. The structure of my study is such: introduction, sections about the author, the analysis of the text, language and narrative features, mythological and epic figures, the transcription of the text and conclusion. In the analysis section which constitutes a large part of my study, the title, the theme, thesis statement, the plot, the structure of motives, time and place, figures, the narrative properties and the other factors in the text, (animals, occupations, music and cosmic universe), are all examined thoroughly with examples from the text. The examined attributes of the text are identified and evaluated in the conclusion section. "Alî'nin Hikâye-i Şâh Cihân ve Gevher-Nigîn'i" named story's the text is important because it is based on the narrative, includes many poems in it and through its source, is an example of Camasabname's stories. Key words: Classical Turkish Literature, "Alî'nin Hikâye-i Şâh Cihân and Gevher-Nigîn'i", Alî, prosaic tale traditio
Development of an Intelligent Model to Estimate the Probability of having Metabolic Syndrome
No full textAbstractLogistic regression has now become an essential part of medical data analysis that uses a binary-response model. The model is frequently used by epidemiologists as a model for the probability (interpreted as the risk) that an individual will acquire a disease during a specified time period, during which he or she is exposed to a condition (called a risk factor) known to be or suspected of being associated with the disease. The objective is to establish a model using a minimum number of variables, and is also able to identify the relationship between the dependent variable and independent variable. Additionally, the study will determine the risk factors that can lead to the development of metabolic syndrome (MetSyn) and will establish an intelligent and biologically acceptable model for estimating the probability of having the condition, based on the NCEP ATP III criteria. In this study, binary logistic regression analysis has been employed in order to specify the risk factors that affect metabolic syndrome. Metabolic syndrome (MetSyn) is a common metabolic disorder that is increasingly caused by the pervasiveness of obesity in society and diagnosed according to the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) Identification1. The data has been obtained from the laboratory test results of 321 adult individuals who had consecutively been treated by the Near East University Internal Medicine Department. For this intelligent model, binary logistic regression analysis has been used. The sensitivity, specificity and accuracy rates have been detected as 94.7%, 96.0% and 95.5%, respectively. As a result, homeostatic model assessment (HOMA-IR), uric acid, body mass index (BMI), low-density lipoprotein (LDL) cholesterol, age, smoking, education level (EL) are defined as metabolic syndrome risk factors, the model has been estimated by using those variables in the acquired intelligent model. As a consequence of the research, it has been determined that the key elements that can have an impact are the changeable risk factors, meaning that the illness could be destroyed before it actually occurs, and lifestyle change, that can also prevent the illness
Phosphorus-Nitrogen compounds part 47: The conventional and microwave-assisted syntheses of dispirocyclotriphosphazene derivatives with (4-fluoro/4-nitrobenzyl) pendant arms: Structural and stereogenic properties and DNA interactions
No full textWOS: 000463348300022The Cl exchange reactions of hexachlorocyclotriphosphazene, N3P3Cl6, with two equimolar amounts of N-alkyl-N'-mono(4-fluorobenzyl)diamines (1-3), FC6H4CH2NH(CH2)(n)NHR1 (n=2 and 3, R-1=CH3 or C2H5), and N-alkyl-N'-mono(4-nitrobenzyl)diamines (4 and 5), NO2C6H4CH2NH(CH2)(n)NHR1 (n= 2, R-1= CH3 or C2H5), led to the formation of the mono(4-fluorobenzyl) (1a-3a) and mono(4-nitrobenzyl) (4a and 5a) spirocyclotriphosphazenes as minor products, and trans-bis(4-fluorobenzyl) (1b-3b) and trans-bis(4-nitrobenzyl) (4b and 5b) spirocyclotriphosphazenes as major products. The bis(4-fluorobenzyl) spirocyclotriphosphazene (1b) reacted with excess pyrrolidine to give fully substituted (1c) phosphazene. The structures of the new compounds were elucidated by elemental analyses, ESI-MS, FTIR, H-1, C-13, and P-31 NMR techniques. The molecular and crystal structures of 1a, 3b and 6 were identified by single crystal X-ray crystallography. The absolute configurations of 3b and 6 were unambiguously established as SS and R respectively, using X-ray crystallographic data. On the other hand, the interactions of 1b, 1c, 3b-5b and 6 with plasmid DNA indicated that compounds 3b, 4b, and 5b caused a decrease in the mobilities and intensities of form I and form II DNA. Compounds 1b, 1c and 6 caused a double strand break of plasmid DNA. All of the tested compounds inhibited enzyme cleavage indicating compound bindings to the specific G/G and A/A nucleotides.Turkish Academy of Sciences (TUBA); Hacettepe University Scientific Research Project Unit [013 D04 602 004]The author Z. K. thanks to Turkish Academy of Sciences (TUBA) for the partial support of this study. T. H. is grateful to Hacettepe University Scientific Research Project Unit (Grant No. 013 D04 602 004)
Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts
No full textIn summary, the present results indicate that a-synuclein seeds in brain tissue resist formaldehyde fixation as previously reported for Aβ. It is likely, albeit to be proven, that this is also true for aggregated tau other self-propagating pathogenic protein aggregates. These findings can now be exploited to further establish the relationship between the molecular architecture of a-synuclein lesions and individual pathogenesis and thereby exploit archived formalin-fixed brain material
Aman Muhtar’ın “Ayållär Mämläkäti Ve Sältänäti” adlı eserindeki hikâyeler üzerine dil ve üslup incelemesi
No full textBu çalışmada, Özbek şair ve yazarı Aman Muhtar’ın Ayoller Mamlakati ve Saltanati adlı eserindeki dokuz hikâyenin dil ve üslup incelemesi yapılmıştır. Çalışmanın Giriş bölümünde Özbekler ve Özbekistan, Özbek edebiyatının 20. yüzyıl öncesi ve 20. yüzyıl sonrası hakkında genel bilgi verilmiştir. Çalışmanın Birinci bölümünde Aman Muhtar’ın hayatı, edebî kişiliği ve eserlerine değinilmiştir. İkinci bölüm Dil ve Üslup İncelemesi başlığını taşımaktadır. Bu bölümde eserin fonolojik, morfolojik ve sentaktik özellikleri incelenip muhteva ve üslup unsurları ortaya konulmuştur. Ay”rıca bu bölümde, eser içinde yer alan kelime ve cümlelerden örnekler verilmeye çalışılmıştır. Üçüncü bölüm Metinler bölümüdür. Bu bölümde eserin transkripsiyonu ve Türkiye Türkçesine aktarımı bulunmaktadır. Çalışmanın Dördüncü ve son bölümü ise Sözlük bölümüdür; hikâyelerde geçen her kelime metin içerisindeki karşıladığı anlam ile verilmiştir. Değerlendirme ve Sonuç kısmında; genel bir değerlendirme ile dikkat çeken hususlar belirtilerek çalışma özetlenmiş, Kaynaklar bölümüyle de tamamlanmıştır. Çalışmamıza konu olan Aman Muhtar’ın hikâyeleri, Buhara ve Buhara’da yaşayan insanlar hakkındadır. Bu hikâyelerde yazar; gördüğü, bildiği Buhara’yı, Taşkent’i anlatmış; buralarda yaşayan insanların aşklarını, gençlik arzularını ve aile problemlerini konu edinmiştir.In this study, language and style analysis of nine stories in Ayoller Mamlakati and Saltanati by Uzbek poet and writer Aman Muhtar was examined. In the introduction part of our study, information about Uzbeks and Uzbekistan, Uzbek literature before and after the 20th century was tried to be given. In the first part of the study, the life, literary personality and works of Aman Muhtar were mentioned. The second part is Language and Style Analysis section. In this section, phonological, morphological and syntactic features of the work were examined and content and stylistic elements were presented. Also in this section, examples of words and sentences in the work were tried to be given. Third part is the texts section. This section includes the transcription of the work and its transfer of Turkey to the Turkish work. The fourth and last part of our study is the dictionary section; each word in the stories was given with the meaning it meets in the text. In the Evaluation and Conclusion section; the study was summarized by specifying the points that attract attention with an overall assessment and completed with the resources section. The stories of Aman Muhtar, which is the subject of our study, are about Bukhara and Bukhara people. In these stories, the author deals with Bukhara, Tashkent, which he saw and knew, and family problems, love and desire for youth
Vocabulary examination of Gülten Dayıoğlu's 'Ölümsüz Ece' and its contribution to Turkish teaching
No full textEğitim Bilimleri Enstitüsü, Türkçe ve Sosyal Bilimler Eğitimi Ana Bilim DalıÇalışmamız sırasında Gülten Dayıoğlu'nun Altın Kitaplar yayınlarından çıkan (37. baskı) Ocak 2015 baskısı dikkate alınmıştır. Bu çalışmada Gülten Dayıoğlu'nun "Ölümsüz Ece" adlı romanının söz varlığı açısından incelenmesi ve Türkçe öğretimine katkısı üzerinde durulmuştur. Araştırmamıza kaynak teşkil eden en önemli eser Doğan Aksan'ın "Türkçenin Sözvarlığı" adlı kitabıdır. Söz varlığı içinde yer aldığı toplumun kültürünü taşıyan en önemli araçtır. Çünkü toplumun düşünce dünyası, manevi ve maddi değerleri, hayata bakış açısı, sosyal, ekonomik, kültürel göstergeleri dile yansıyacak, hâliyle söz varlığı, kelime hazinesi olarak deyim, atasözleri, ağız özellikleri; terimler; yiyecek içecek, giyim kuşam isimleri gibi adlar altında karşımıza çıkacaktır. Bu doğrultuda; araştırmaya sorun teşkil eden problem durumu, araştırmanın amacı, araştırmanın önemi, varsayımlar, sınırlılıklar, tanımlar başlıkları ile konu ile ilgili yayın ve araştırmalar incelenmiş, araştırma modeli, evren-örneklem ve bilgi toplama kaynakları, bilgilerin analizi ile yazar hakkında bilgilere yer verilmiş, roman hakkında özet ile eserin Türkçe öğretimine katkısı ve söz varlığı unsurlarının neler olduğu açıklanmaya çalışılmış; "Ölümsüz Ece" romanında geçen isimlerin sınıflandırılması ve romandaki söz varlığı unsurlarının tespiti ile birlikte, sunduğumuz söz varlığı öğeleri sayfa numaraları, sıklıkları ve örnek teşkil eden cümleler dikkate alınarak bir düzen oluşturulmaya çalışılmıştır. Sonuç kısmında tespitlerimize yer verilmiş kaynakça kısmında ise çalışmamıza dolaylı ya da doğrudan kaynak teşkil eden eserlerin bilgisi verilmiştir. Anahtar Sözcükler: Sözvarlığı, Türkçe öğretimi, Ölümsüz Ece, Gülten Dayıoğlu, Çocuk edebiyatıDuring the study, January 2015 edition of Gülten Dayıoğlu's Golden Books (37th edition) was taken into consideration. Our study includes Gülten Dayıoğlu's "Ölümsüz Ece" novel's vocabulary and its contribution to Turkish teaching. The most important work that constitues the source of our research is Doğan Aksan's "Türkçenin Sözvarlığı" is his book. Vocabulary is the most important tool that carries the culture of the society. Because the world of thought, spiritual and material values of the society, the perspective of life, social, economic, cultural indicators will be reflected in the language, as vocabulary, as vocabulary idoms, proverbs, mouth characteristics; terms, food, drink, clothing names will apper under names such as. In this direction; the problem situation of the research, the purpose of the research, the importance of the research, the assumptions, limitations of the headings and related publications and researches have been examined, research model, universe-sampling and information collection resources, information about the author with information about the novel, including a summary the contribution of the work to the teaching of Turkish and the elements of vocabulary are tired to be explained, the classification of the names mentioned in the novel " Ölümsüz Ece" according to the concept area and determining the elements vocabulary in the novel, an order has been tried to be taken into consideration by taking into account the page numbers, freguencies and exemplary sentences of our vocabulary items. In the conclusion part of the book, we gave information about the works that are the source of our works. Key words: Vocabulary, Teaching Turkish, Ölümsüz Ece, Gülten Dayıoğlu, Children's Literatur
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