204 research outputs found
Contribution of Neurogenic and Allergic Ways to the Pathophysiology of Nonallergic Rhinitis
No full textBackground: A neuroallergic interaction was reported in the pathogenesis of allergic rhinitis (AR), but the pathophysiology of nonallergic rhinitis (NAR) is poorly understood. We aimed to explore the contribution of neuroallergic mechanisms to the pathogenesis of NAR. Methods: Subjects were divided into three groups - NAR patients (n = 25), AR patients (n = 16) and the control group (n = 10) - and were assessed using the nasal provocation test (NPT) with house dust mite. Total symptom scores, nasal inspiratory peak flow and nasal lavage were performed before and after NPT. Nasal brushing and scraping was done after NPT. Results: NPT was positive in NAR (52%) and AR (100%) patients and negative in all controls. After NPT, total symptom scores increased in both rhinitis groups. Post-NPT values of nasal inspiratory peak flow decreased only in AR patients. NAR patients showed a similar inflammatory cell profile in the nasal smears to AR patients which was different in controls. There were more tryptase- and immunoglobulin E (IgE)-positive cells in the nasal mucosa of AR patients, and more substance-p-positive cells were observed in NAR patients compared with controls. However, IgE- and tryptase-positive cells in NAR patients and substance-p-positive cells in AR patients were detectable in nasal mucosa, but rarely in the controls. Comparing the values before and after NPT, tryptase significantly increased in the nasal lavages of AR and NAR patients, while house dust mite-specific IgE did not change. Conclusions: We showed the existence of a common pathophysiological mechanism with different contributions in AR and NAR. We conclude that the difference in dominance of neuroallergic ways may determine the major phenotype of rhinitis. Copyright (C) 2012 S. Karger AG, BaselKirikkale University Projects of Scientific ResearchesKirikkale University [2007/4]This work was supported by a grant from Kirikkale University Projects of Scientific Researches (grant No. 2007/4) which was received by Baccioglu Kavut and Fusun Kalpaklioglu
Which way will Tatar cultur go ? A controversial essay by Galimdzhan Ibragimov
No full textAzade-Ayse Rorlich, Which way will Tatar culture go ? A controversial essay by Galimdzhan Ibragimov.
The present article discusses G. Ibragimov's essay Which way will Tatar culture go ? which demonstrates his awareness of the historical traditions, peculiarities of the Volga Tatars as well as the need to preserve and develop the national identity in the future. Since in his essay Ibragimov posed two alternatives for the future of Tatar culture: russification or survival, the author of this article concentrated around the same issue, comparing Ibragimov's theses with those of other Tatar intellectuals concerned with the future of the Tatar nation. Ibragimov considered the national language as the main ingredient of a national culture and the present article discusses his struggle around this issue as well as his belief that the future of the Tatar culture depended upon the future of the Tatar language.Azade-Ayse Rorlich, Où ira la culture tatare ? Un essai critique de Galimdzhan Ibragimov.
Le présent article discute un essai de G. Ibragimov intitulé Оù ira la culture tatare ? qui démontre la haute conscience qu'avait Ibragimov des traditions historiques et des caractères propres aux Tatars de la Volga, ainsi que la nécessité de préserver et de développer à l'avenir leur identité nationale. Étant donné que, dans son essai, Ibragimov a posé, pour l'avenir de la culture tatare, l'alternative suivante : russification ou survie, la présente étude est centrée sur le même problème et compare les thèses ď Ibragimov à celles des autres intellectuels tatars préoccupés de l'avenir de la nation tatare. Ibragimov considérait la langue nationale comme le principal élément d'une culture nationale ; le présent article remet en cause la bataille qu'il livra à ce sujet et sa conviction que l'avenir de la culture tatare dépendait de celui de la langue tatare.Rorlich Azade-Ayse. Which way will Tatar cultur go ? A controversial essay by Galimdzhan Ibragimov. In: Cahiers du monde russe et soviétique, vol. 15, n°3-4, Juillet-décembre 1974. pp. 363-371
Terrorisme, immigration et patriotisme. Les identités sous surveillance
No full textLes attentats du 11 septembre ont eu pour conséquence d’établir une association entre terrorisme et immigration et de mettre en avant la sécurité de la patrie, conduisant à soulever la question de l’allégeance des citoyens d’origine étrangère envers les Etats-Unis. Dans cet article, Ayse Ceyhan analyse les effets des attentats sur l’image et l’identité multiculturaliste des Etats-Unis. Dans cet article, l’auteur souligne que la peur du terrorisme infiltré est devenue la préoccupation sécuritaire majeure. Mais la recherche d’une surveillance accrue des individus et groupes suspects et les mesures adoptées ne sont pas neuve.The attacks of September 11th have consequently established an association between terrorism and immigration and have favoured the idea of national security, which led to questioning the allegiance of citizens from a foreign origin towards the United-States. Ayse Ceyhan analyses the effects of the attacks on the image of the American multicultural identity. The author shows in this article that the fear of an infiltrated terrorism has become the main security preoccupation. Nevertheless, the quest for an increased surveillance of suspect individuals and groups and the measures that have been adopted are not new
Does Serum Leptin Differ Between Patients With Rhinitis Of Allergic Vs Nonallergic Aetiology?
No full textAnnual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI) -- FEB 28-MAR 04, 2014 -- San Diego, CA…Amer Acad Allergy Asthma & Immuno
Asthma as a Comorbid Disease in COVID-19
No full textBavbek, Sevim/0000-0002-7884-0830Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel coronavirus that causes coronavirus disease 2019 (COVID-19). In terms of asthma and COVID-19, there is also a risk of experiencing an asthma exacerbation triggered by coronavirus infection beyond the direct risk of the infection itself. As a comorbid disease, the prevalence of COVID-19 infection in asthma patients is not clear. In addition, the influence of asthma on the severity of COVID-19 has not been reported. The aim of this review was to summarize the reported worldwide data about the prevalence and the clinical characteristics of patients with asthma during COVID-19 infection
Pathway modeling: from gene expression to pathway dynamics
No full textBiological pathways represent a critical level of biological organization and understanding of biochemical pathways is identified as key to future advances in biological sciences (Schaefer, 2004). The overall goal of this thesis is to develop a pathway based approach that integrates different aspects of biological pathways, specifically the structure and the dynamics of a pathway in order to characterize cells’ behavior. Our objectives are to asses structural and functional cross-species comparison of pathways (Chapter 2), to formulate a reliable pathway activity metric based on gene expression data (Chapter 3), to demonstrate that our pathway activity formulation can predict the underlying dynamics (Chapter 4) and finally to demonstrate that the pathway activity formulation can identify cell’s response to a stimulant (Chapter 5). Chapter 3-5 present how a significant pathway can be identified. Then, cross-species comparison of pathways (Chapter 2) can be used. Note that we could have Chapter 2 and Shapter 5 swapped for a more fluent flow. Neverthless, we present the chapters in this order for a better read. In Chapter 2, we propose an improvement of the reaction alignment method, emerged as the most successful pathway comparison method, by accounting for sequence similarity in addition to reaction alignment method. Using nine species, including human and some model organisms and test species, we evaluate the standard and improved comparison methods by analyzing glycolysis and citrate cycle pathways conservation. In addition, we demonstrate how organism comparison can be conducted by accounting for the cumulative information retrieved from nine pathways in central metabolism as well as a more complete study involving 36 pathways common in all nine species. In Chapter 3, we explore an extension of the pathway activity methodology which entails singular value decomposition (SVD) of the expression data of the genes constituting a given pathway. We show that pathway analysis enhances our ability to detect relevant changes in pathway activity using synthetic data. In addition, we illustrate that pathway activity formulation should be coupled with a significance analysis to distinguish significant information from random deviations.In Chapter 4, we perform an unsupervised pathway level analysis, based on the formulation presented in Chapter 3, on a rich time series of transcriptional profiling in rat liver. The over-represented five specific patterns of pathway activity levels, which cannot be explained by random events, exhibit circadian rhythms. The identification of the circadian signatures at the pathway level identify pathways related to energy metabolism, amino acid metabolism, lipid metabolism and DNA replication and protein synthesis, which are biologically relevant in rat liver. In Chapter 5, we demonstrate that our pathway activity formulation enables us to detect relevant changes in pathways due to in utero di-butyl-phthalate (DBP) exposure. Our findings suggest that the pathways that produce precursors to cholesterol synthesis exhibit more significant change compared to the rest of the affected pathways. In addition, pathway activity levels of certain biological functions accompany testosterone decrease, which is the critical event for male reproductive developmental effects of DBP, such as steroid hormone metabolism and biosynthesis of steroids.Ph.D.Includes bibliographical referencesIncludes vitaby Ayse Meric Ovaci
Rationale for the autologous serum skin test in acute versus chronic urticaria
No full textIntroduction: Autologous serum skin test (ASST) is a rapid, in-vivo clinical test to detect functional autoantibodies in patients with chronic spontaneous urticaria (CSU), but the rationale for its use in acute urticaria (AU) is unknown. Aim: To evaluate the efficacy of ASST among patients with AU or CSU. Material and methods: Treatment-naIve adult (age >= 18 years) patients with a diagnosis of AU ( 100 IU/ml) in AU (85.2%) and CSU (65.2%) groups was similar (p = 0.06), but significantly higher than in the control group (10.7%) (p < 0.001 and p < 0.001). The CSU group had significantly higher abnormal thyroid test results (45.7%) than AU (14.8%) and control groups (3.6%) (p = 0.01 and p < 0.001), whereas patients with clinically diagnosed thyroiditis were only in the CSU group (6.5%). In logistic regression analysis, there was no relation found among the possible risk factors for ASST, even if analysed separately as AU, CSU and control groups. Conclusions: Even though thyroid function test levels were found to be related with CSU, and total IgE was associated with urticaria, ASST was found to be of importance. This study confirms that ASST was insufficient to demonstrate autoimmunity and acute-chronic urticaria nature. Further tests indicating auto-antibodies in AU and CSU are needed
Editorial: Compartmental models for social interactions
No full text[No Abstract Available]National Recovery and Resilience Plan (NRRP); Mission 4 Component 2 Investment [3277]; European Union [ECS00000033, 1052]The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This research is partially funded under the National Recovery and Resilience Plan (NRRP), and Mission 4 Component 2 Investment 1.5-Call for tender No. 3277 of 30/12/2021 of Italian Ministry of University and Research funded by the European Union-NextGenerationEU Award Number: Project code ECS00000033, Concession Decree No. 1052 of 23/06/2022 adopted by the Italian Ministry.Science Citation Index Expande
Comparison of azelastine versus triamcinolone nasal spray in allergic and nonallergic rhinitis
No full text65th Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology -- MAR 13-17, 2009 -- Washington, DCBackground: Intranasal antihistamine has not been thoroughly studied in the treatment of rhinitis of different etiologies. This study was designed to show the comparative efficacy of nasal antihistamine and nasal corticosteroid in patients with allergic rhinitis (AR) and nonallergic rhinitis (NAR). Methods: A comparison of the efficacy of azelastine nasal spray (AZENS) versus triamcinolone acetonide nasal spray (TANS) on total nasal symptom scores (TNSS), nasal peak inspiratory flow rate (nPIFR), and nasal cytology was studied in a 2-week randomized parallel-group trial. The Epworth Sleepiness Scale (ESS) and health-related quality of life (HRQoL) were also analyzed. Results: The study group consisted of 132 patients (100 women and 32 men) with a mean age of 33.14 +/- 12.52 years, Sixty-nine patients had AR and 63 had NAR. Although TNSS including sneezing, itching, rhinorrhea, congestion-but not anosmia-significantly improved in both groups, intranasal azelastine reduced ocular symptoms greatly compared with intranasal triamcinolone (p = 0.05). Patients with NAR seemed to respond more to TANS, whereas AZENS was more useful in AR. The nPIFR improved in AR and NAR, with no significant difference between the treatment groups. Neither intranasal azelastine nor intranasal triamcinolone changed cytology in nasal lavage. Both medications were well tolerated, but AZENS led to more adverse events than TANS (56.9 and 19%, respectively; p = 0.001), mainly because of bitter taste. Scores on each domain of generic HRQoL (36-Item Short-Form Health Survey) and mini-rhinitis QoL questionnaires, as well as ESS score, significantly improved in both groups, irrespective of rhinitis etiology. Conclusion: In this first comparative demonstration, AZENS appears to be as effective as triamcinolone in symptom scores, nPIFR, ESS, and HRQoL, equally in AR and NAR. (Am J Rhinol Allergy 24, 29-33, 2010; doi: 10.2500/ajra.2010.24.3423)Amer Acad Allergy Asthma & Immunol (AAAAI
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