1,721,032 research outputs found
Epyadriamicin concentration in experimental hepatic metastases after bolus or continuous infusion through systemic or locoregional routes
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PET/CT in patients with peritoneal carcinomatosis undergoing hypertemic intraperitoneal chemotherapy (HIPEC) following cytoreductive surgery.
No full textBackground: The peritoneum is the preferred site of metastasis from several primary malignancies, and peritoneal carcinomatosis (PC) is one of the most significant negative prognostic indicators in patients with metastatic disease. A survival benefit has been observed for patients with PC from colorectal, ovarian, and gastric carcinomas treated by cytoreductive surgery (CRS) followed by intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC). In patients undergoing this treatment modality, the strongest determinant of outcome is the residual tumor extension after CRS. Unfortunately, PC can be difficult to diagnose preoperatively by imaging studies. The aim of our study was to evaluate the role of computed tomography (CT) and 18F-2-deoxy-fluoro-D-glucose positron emission tomography/CT (PET/CT) scanning in detecting the presence and the extent of PC in patients with various advanced malignancies.
Patients and Methods: A group of 47 patients (median age 61.4±11.5 years) with advanced or recurrent cancers (colorectal=26, ovarian=21, gastric=8, pseudomyxoma peritonei=3) scheduled for CRS and HIPEC underwent preoperative CT and PET/CT. The results were expressed as sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy. The negative (NLR) and positive (PLR) likelihood ratio were also obtained. The receiver operator characteristic (ROC) curves were drawn, and areas under the curve (AUC) were measured. The 95% confidence interval (95%CI) was also calculated, when appropriate. The results of CT scan and PET/CT were compared with the final surgical findings.
Results: The sensitivity, specificity, PPV, NPV, accuracy were 91%, 33%, 93%, 29% and 69% for CT, and 82%, 67%, 95%, 33% and 71% for PET/CT, respectively. NLR and PLR were 0.27 (95%CI 0.07-1.09) and 1.37 (95%CI 0.76-2.44), while the AUC was 62 and 74 for CT and PET/CT, respectively (p=NS).
Conclusions: In patients with PC undergoing surgery both PET/CT and CT showed low sensitivity, and thus they seem not to be a reliable tool in view of treatment planning. Our study demonstrates that PET/CT does not add substantially to CT scanning in the detection of this disease
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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