169,889 research outputs found
Adaptive bootstrap tests and its competitors in the c-sample scale problem
No full textThis paper deals with a study of different types of tests for the two-sided c-sample scale problem. We consider the classical parametric test of Bartlett [M.S. Bartlett, Properties of sufficiency and statistical tests, Proc. R. Stat. Soc. Ser. A. 160 (1937), pp. 268-282] several nonparametric tests, especially the test of Fligner and Killeen [M.A. Fligner and T.J. Killeen, Distribution-free two-sample tests for scale, J. Amer. Statist. Assoc. 71 (1976), pp. 210-213], the test of Levene [H. Levene, Robust tests for equality of variances, in Contribution to Probability and Statistics, I. Olkin, ed., Stanford University Press, Palo Alto, 1960, pp. 278-292] and a robust version of it introduced by Brown and Forsythe [M.B. Brown and A.B. Forsythe, Robust tests for the equality of variances, J. Amer. Statist. Assoc. 69 (1974), pp. 364-367] as well as two adaptive tests proposed by Buning [H. Buning, Adaptive tests for the c-sample location problem - the case of two-sided alternatives, Comm. Statist.Theory Methods. 25 (1996), pp. 1569-1582] and Buning [H. Buning, An adaptive test for the two sample scale problem, Nr. 2003/10, Diskussionsbeitrage des Fachbereich Wirtschaftswissenschaft der Freien Universitat Berlin, Volkswirtschaftliche Reihe, 2003]. which are based on the principle of Hogg [R.V. Hogg, Adaptive robust procedures. A partial review and some suggestions for future applications and theory, J. Amer. Statist. Assoc. 69 (1974), pp. 909-927]. For all the tests we use Bootstrap sampling strategies, too. We compare via Monte Carlo Methods all the tests by investigating level α and power β of the tests for distributions with different strength of tailweight and skewness and for various sample sizes. It turns out that the test of Fligner and Killeen in combination with the bootstrap is the best one among all tests considered.bootstrap, sampling strategies, parametric, nonparametric, robustified and adaptive tests, tailweight skewness, nonnormality, α-robustness, power comparison,
Choice of tumour markers in patients with neuroendocrine tumours is dependent on the histological grade. A marker study of Chromogranin A, Neuron specific enolase, Progastrin-releasing peptide and cytokeratin fragments
No full textAbstract not availableCatharina M. Korse, Babs G. Taal, Andrew Vincent, Marie-Louise F. van Velthuysen, Paul Baas, Johanna C.G.M. Buning-Kager, Theodora C. Linders, Johannes M.G. Bonfre
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Adaptive Jonckheere-type tests for ordered alternatives
No full textTesting against ordered alternatives in the c -sample location problem plays an important role in statistical practice. The parametric test proposed by Barlow et al .-in the following, called the 'B-test'-is an appropriate test under the model of normality. For non-normal data, however, there are rank tests which have higher power than the B-test, such as the Jonckheere test or so-called Jonckheere-type tests introduced and studied by Buning and Kossler. However, we usually have no information about the underlying distribution. Thus, an adaptive test should be applied which takes into account the given data set. Two versions of such an adaptive test are proposed, which are based on the concept introduced by Hogg in 1974. These adaptive tests are compared with each of the single Jonckheere-type tests in the adaptive scheme and also with the B-test. It is shown via Monte Carlo simulation that the adaptive tests behave well over a broad class of symmetric distributions with short, medium and long tails, as well as for asymmetric distributions.
A new age of precision gene therapy
No full text: Gene therapy has become a clinical reality as market-approved advanced therapy medicinal products for the treatment of distinct monogenetic diseases and B-cell malignancies. This Therapeutic Review aims to explain how progress in genome editing technologies offers the possibility to expand both therapeutic options and the types of diseases that will become treatable. To frame these impressive advances in the context of modern medicine, we incorporate examples from human clinical trials into our discussion on how genome editing will complement currently available strategies in gene therapy, which still mainly rely on gene addition strategies. Furthermore, safety considerations and ethical implications, including the issue of accessibility, are addressed as these crucial parameters will define the impact that gene therapy in general and genome editing in particular will have on how we treat patients in the near future
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
A Multi-Language Comparison of Influences on Author Verification using Character N-Grams
No full textWe create a new multi-language corpus for author verification based on Wikipedia talkpages, and evaluate the influence that differences in topic and time have on character n-gram author profiles. Topic alignment between two texts is found to increase author verification precision, and an authors writing style is found to change over time, but not more significantly after 3 years than after 1 year.Information ArchitectureWISElectrical Engineering, Mathematics and Computer Scienc
A 0.12mm<sup>2</sup> Wien-Bridge Temperature Sensor with 0.1°C (3σ) Inaccuracy from -40°C to 180°C
No full text Resistor-based temperature sensors can achieve much higher resolution and energy efficiency than conventional BJT-based sensors [1], but they typically occupy more area (> 0.25 mm 2 ) and have lower operating temperatures (le 125 {circ} {C}) [2]-[4]. This work describes a 0.12mm 2 resistor-based sensor that uses a Wien-bridge (WB) filter to achieve 0.1 {circ} {C} (3 sigma) inaccuracy from - 40 {circ} {C} to 180 {circ} {C}. Compared to a state-of-the-art WB sensor [4], it occupies 6 × less area and achieves comparable relative accuracy over a 76% wider operating range. Session 10.3 Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic InstrumentationMicroelectronic
A ±25A Versatile Shunt-Based Current Sensor with 10kHz Bandwidth and ±0.25% Gain Error from -40°C to 85°C Using 2-Current Calibration
No full textAccurate current sensing is critical in many industrial applications, such as battery management and motor control. Precise shunt-based current sensors have been reported with gain errors of less than 1% over the industrial temperature range (-40°C to 85°C) [1]–[4]. However, since they are intended for coulomb counting, their bandwidth is limited to a few tens of Hz, making them unsuitable for battery impedance or motor-current sensing. This paper presents a current sensor with a wide (10kHz) bandwidth and a tunable temperature compensation scheme (TCS), which allows it to be flexibly used with different types of shunts while maintaining high accuracy. A low-cost room-temperature calibration scheme is proposed to optimize gain flatness over temperature by exploiting the shunt's self-heating at large currents. Over the industrial temperature range and a ±25A current range, it achieves state-of-the-art gain error (±0.25%) with both low-cost PCB and stable metal-alloy shunts.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic InstrumentationMicroelectronic
- …
