322,941 research outputs found
RELATIONSHIP OF THE INCREASED SERUM INTERLEUKIN-6 CONCENTRATION TO CHANGES OF THYROID-FUNCTION IN NONTHYROIDAL ILLNESS
No full textA special case of bilateral ovarian metastases in a woman with papillary carcinoma of the thyroid
No full textPapillary thyroid carcinoma is a slow growing tumor with low metastatic
potential. The most frequent sites of distant metastases are lung and bone; less
frequent sites are brain, liver, kidney, and skin. Ovarian metastases from
papillary thyroid carcinoma are exceptional. We describe a case of bilateral
ovarian metastases from a papillary thyroid carcinoma associated with autoimmune
thyroiditis in a 38-year-old woman who underwent thyroidectomy and cervical
lymph-node dissection 7 years before, followed by 948 mCi of 131I. A primary
ovarian cancer could be excluded by the typical pathological aspects of a
papillary thyroid carcinoma in a context of an aggressive form of thyroid cancer.
On the other hand, the clinical history and the absence of normal thyroid
epithelium and teratomatous components could exclude a papillary thyroid
carcinoma arising in struma ovarii. This is a singular case of papillary thyroid
carcinoma metastasizing to the ovary, combined with an autoimmune thyroiditis
Treatment of amiodarone induced thyrotoxicosis: a difficult challenge: results of a prospective study
No full textUnusually strong H-bonding to the heme ligand and fast geminate recombination dynamics of the carbon monoxide complex of Bacillus subtilis truncated hemoglobin.
No full textThe active site of the oxygen-avid truncated hemoglobin from Bacillus subtilis has been
characterized by infrared absorption and resonance Raman spectroscopies, and the dynamics of CO
rebinding after photolysis has been investigated by picosecond transient absorption spectroscopy. Resonance
Raman experiments on the CO bound adduct revealed the presence of two Fe-CO stretching bands at
545 and 520 cm-1, respectively. Accordingly, two C-O stretching bands at 1924 and 1888 cm-1 were
observed in infrared absorption and resonance Raman measurements. The very low C-O stretching
frequency at 1888 cm-1 (corresponding to the extremely high RR stretching frequency at 545 cm-1)
indicates unusually strong hydrogen bonding between CO and distal residues. On the basis of a comparison
with other truncated hemoglobin it is envisaged that the two CO conformers are determined by specific
interactions with the TrpG8 and TyrB10 residues. Mutation of TrpG8 to Leu deeply alters the hydrogenbonding
network giving rise mainly to a CO conformer characterized by a Fe-CO stretching band at 489
cm-1 and a CO stretching band at 1958 cm-1. Picosecond laser photolysis experiments carried out on the
CO bound adduct revealed dynamical processes that take place within a few nanoseconds after photolysis.
Picosecond dynamics is largely dominated by CO geminate rebinding and is consistent with strong
H-bonding contributions of TyrB10 and TrpG8 to ligand stabilization
Color flow Doppler sonography rapidly differentiates type I and type II amiodarone-induced thyrotoxicosis.
No full textAmiodarone-induced thyrotoxicosis (AIT) occurs both in abnormal thyroid glands (nodular goiter, latent Graves' disease) (type I AIT) or in apparently normal thyroid glands (type II AIT). Differentiation of the two forms is crucial, because type I AIT responds well to methimazole and potassium perchlorate combined treatment, whereas type II AIT is effectively managed by glucocorticoids. Differential diagnosis is often difficult, although thyroid radioactive iodine uptake is usually low-to-normal in type I and low-suppressed in type II, and serum interleukin-6 levels are normal/slightly elevated in type I, markedly elevated in type II. Color flow Doppler sonography (CFDS) is a technique that shows intrathyroidal blood flow and provides real-time information on thyroid morphology and hyperfunction. To investigate the usefulness of CFDS in differentiating the two types of AIT, 27 consecutive AIT patients, 11 type I and 16 type II, were evaluated by CFDS before starting antithyroid treatment. Gender, age, severity of thyrotoxicosis, and cumulative amiodarone dose were similar in the two groups. All type II AIT patients had a CFDS pattern 0 (ie, absent vascularity), in agreement with the pathogenesis of the disease, due to thyroid damage. Likewise, nine patients with subacute thyroiditis, another destructive process of the thyroid gland, also had a CFDS pattern 0. Eleven patients with type I AIT had a CFDS pattern ranging from pattern I (presence of parenchymal blood flow with patchy uneven distribution) (7 patients, 64%) to pattern II (ie, mild increase of color flow Doppler signal with patchy distribution) (1 patient, 9%) and pattern III (markedly increased color flow Doppler signal with diffuse homogeneous distribution)(3 patients, 27%), similar to that found in patients with untreated Graves' disease patients, thus indicating a hyper-functioning gland. Control subjects and euthyroid patients under long-term amiodarone treatment had absent thyroid hypervascularity and a CFDS pattern 0. These findings demonstrate that CFDS distinguishes type I and II AIT. Because of its rapidity and noninvasive features, CFDS represents a valuable tool for a quick differentiation between the two types of AIT. This can avoid any delay in initiating the appropriate treatment for a rapid control of thyrotoxicosis in patients whose tachyarrhythmias or other cardiac disorders make thyroid hormone excess extremely deleterious
Diffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
- …
