1,721,110 research outputs found
Carbon dioxide therapy in the treatment of localized adiposities: clinical study and histopathological correlations
No full textAesthetic Plast Surg. 2001 May-Jun;25(3):170-4.
Carbon dioxide therapy in the treatment of localized adiposities: clinical study and histopathological correlations.
Brandi C, D'Aniello C, Grimaldi L, Bosi B, Dei I, Lattarulo P, Alessandrini C.
Source
Unità Operativa di Chirurgia Plastica, Università digli Studi di Siena, Policlinico Le Scotte, Italy. [email protected]
Abstract
The authors report their experience using carbon dioxide (CO2) therapy for the treatment of 48 female patients presenting adipose accumulations, located on the thighs, knees, and/or abdomen; a Carbomed Programmable Automatic Carbon Dioxide Therapy apparatus was used. In light of the effects of CO2 on the microcirculation recently described in the literature, we expected this gas, which we administered subcutaneously, to positively affect the physiological oxidative lipolytic process. The aim of our study was to evaluate the effect of this therapy on localized adiposities. As such, we describe the method we used and report the results observed in the areas treated (in terms of reduction in maximum circumference) as well as side effects. Furthermore, we assessed the effect of subcutaneous administration of CO2 on the microcirculation by showing changes in the Laser Doppler signal and in the concentration of transcutaneous oxygen tension (tcPO2). Pre- and posttreatment biopsies of tissues were performed in seven patients in order to study the changes induced by the use of CO2 on both adipose and connective tissues. All data obtained were statistically analyzed; values of P < 0.05 were considered significan
Treatment with vacuum-assisted closure and cryo-preserved homologous de-epidermalised dermis of complex traumas to the lower limbs with loss of substance, and bones and tendons exposure
No full textJ Plast Reconstr Aesthet Surg. 2008 Dec;61(12):1507-11. Epub 2007 Nov 13.
Treatment with vacuum-assisted closure and cryo-preserved homologous de-epidermalised dermis of complex traumas to the lower limbs with loss of substance, and bones and tendons exposure.
Brandi C, Grimaldi L, Nisi G, Silvestri A, Brafa A, Calabrò M, D'Aniello C.
Source
Department of General and Specialist Surgery, Plastic Surgery Unit, University of Siena, Polyclinic S Maria alle Scotte, Viale Bracci, Sienna, Italy. [email protected]
Abstract
SUMMARY: Lower-limb injuries with loss of tissue and exposure of bones and tendons are an increasing problem. The condition of the wound locally and the patient in general does not always allow immediate and adequate coverage of the structures exposed by the trauma. Therefore, new therapeutic solutions are needed. A reduction in the time that bones and tendons are exposed is essential to achieve complete healing of bone fractures, with reduced risks of infection and less disabling outcomes. The effectiveness of vacuum-assisted closure (VAC) therapy in supporting wound healing and of cryopreserved homologous de-epidermalised dermis (DED) in providing an effective template for re-epithelialisation has been previously reported. We carried out a study to evaluate the effectiveness of the synergistic and combined use of the two methodologies. Eighteen patients with traumatic loss of tissue in the lower limbs, involving exposure of bone and tendon structures, were enrolled in the study. All participants had local, general contraindications to first-instance reconstructions, or both. All patients received a combination of VAC therapy and DED implants. Granulation tissue was obtained in all wounds, with complete coverage of exposed structures. No infections were detected in the cohort, and all patients were prepared for further necessary reconstructive treatments. In our experience, the combination of VAC therapy and DED could, in selected cases, constitute an effective treatment for complex lower limb traumatic injuries with bone and tendon exposure
A rare case of Merkel's cell carcinoma located on the upper eyelid in a young patient [Un raro caso di carcinoma a cellule di Merkel a localizzazione palpebrale superiore in una giovane paziente]
No full textMerkel's cell carcinoma is considered to be a rare disease, with recent literature describing no more than 430 cases, in 90% of whom onset was in patients aged over 50 years. The authors present a case of Merkel's cell carcinoma located on the upper eyelid which, unusually, had onset in a patient aged 31 years. Rapid growth of the neoplasm dictated immediate excision of the lesion, almost totally sacrificing the upper eyelid, followed by reconstruction adopting a mixed technique (cartilage graft, cutaneous flap, conjunctival flap and, skin graft). Surgical treatment ensured local radical removal and reconstruction enabled the patient to preserve effective blepharal mobility, with stable results at seven months
Sniping at web applications to discover input-handling vulnerabilities
No full textWeb applications play a crucial role in modern businesses, offering various services and often exposing sensitive data that can be enticing to attackers. As a result, there is a growing interest in finding innovative approaches for discovering vulnerabilities in web applications. In the evolving landscape of web security, the realm of fuzz testing has garnered substantial attention for its effectiveness in identifying vulnerabilities. However, existing literature has often underemphasized the nuances of web-centric fuzzing methodologies. This article presents a comprehensive exploration of fuzzing techniques specifically tailored to web applications, addressing the gap in the current research. Our work presents a holistic perspective on web-centric fuzzing, introduces a modular architecture that improves fuzzing effectiveness, demonstrates the reusability of certain fuzzing steps, and offers an open-source software package for the broader security community. By addressing these key contributions, we aim to facilitate advancements in web application security, empower researchers to explore new fuzzing techniques, and ultimately enhance the overall cybersecurity landscape
A rare case of Merkel's cell carcinoma located on the upper eyelid in a young patient [Un raro caso di carcinoma a cellule di Merkel a localizzazione palpebrale superiore in una giovane paziente]
No full textMerkel's cell carcinoma is considered to be a rare disease, with recent literature describing no more than 430 cases, in 90% of whom onset was in patients aged over 50 years. The authors present a case of Merkel's cell carcinoma located on the upper eyelid which, unusually, had onset in a patient aged 31 years. Rapid growth of the neoplasm dictated immediate excision of the lesion, almost totally sacrificing the upper eyelid, followed by reconstruction adopting a mixed technique (cartilage graft, cutaneous flap, conjunctival flap and, skin graft). Surgical treatment ensured local radical removal and reconstruction enabled the patient to preserve effective blepharal mobility, with stable results at seven months
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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