1,721,296 research outputs found
La teoria dell’attaccamento e la ricerca. Il contributo che la teoria dell’attaccamento ha apportato nello studio del trauma della Shoah sia nei sopravvissuti che nella trasmissione intergenerazionale
No full textIl contributo che la teoria dell’attaccamento ha apportato nello studio del trauma della Shoah sia nei sopravvissuti che nella trasmissione intergenerazionale del traum
Parution : B. Bove, M. Gaude-Ferragu, C. Michon (dir.), Paris, ville de cour (XIIIe-XVIIIe siècle), Rennes, PUR, 2017.
No full textB. Bove, M. Gaude-Ferragu, C. Michon (dir.), Paris, ville de cour (XIIIe-XVIIIe siècle), Rennes, PUR, 2017 Les historiens s’intéressant rarement au cadre urbain des séjours de la cour, ce livre vise à réconcilier l’histoire de la cour avec l’histoire urbaine en général, et avec Paris en particulier. Il s’agit d’un véritable livre collectif qui explore le problème de la présence physique du roi et de ses gens dans la ville, mais aussi celui des effets socio-économiques et politiques de la co..
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Activity-driven computational strategies of a dynamically regulated integrate-and-fire model neuron
No full textActivity-dependent slow biochemical regulation processes, affecting intrinsic properties of a neuron, might play an important role in determining information processing strategies in the nervous system. We introduce second-order biochemical phenomena into a linear leaky integrate-and-fire model neuron together with a detailed kinetic description for synaptic signal transduction. In this framework, we investigate the membrane intrinsic electrical properties differentiation, showing the appearance of activity-dependent shifts between integration and temporal coincidence detection operating mode, for the single unit of a network
Pharmacokinetic drug evaluation of ezetimibe + simvastatin for the treatment of hypercholesterolemia.
No full textIntroduction: Cholesterol lowering treatment is mainly based on statins eventually associated to adjunctive drugs of different class such as ezetimibe. In the present review, we analysed the pharmacokinetics, efficacy and safety of ezetimibe + simvastatin drug association. Areas covered: The bio-equivalence of ezetimibe and simvastatin when co-administrated in separate tablets or combined in a single pill is well documented. Ezetimibe is absorbed in small intestine, reaching peak plasma concentrations in 4–12 h, with a plasma half-life of 22 h. Simvastatin, ingested as a prodrug, is hydrolyzed in liver to its active beta-hydroxyacid metabolite, reaching peak plasma concentrations in 2–4 h, with a plasma half-life of approximately 5 h. The available evidence support the clinical efficacy of this drug combination, both in term of LDL-cholesterol reduction and cardiovascular risk decrease. Expert opinion: The synergistic action of these two drugs and the efficacy and safety extensively demonstrated of their association (in particular in the large IMProved Reduction of Outcomes: Vytorin Efficacy International Trial -IMPROVE-IT-) promote its clinical use, especially in subjects with high cardiovascular risk who need to optimize their LDL-Cholesterolemia, but also in patients who cannot tolerate high-dose of more powerful statins
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