1,720,969 research outputs found
Ruolo dei polimorfismi del CYP450 1A2 negli eventi avversi da clozapina: uno studio osservazionale.
Full text linkObjectives: The genetically polymorphic enzyme cytochrome P450 (CYP) 1A2
contributes to the biotransformation of the antipsychotic drug clozapine (CLO). Two
polymorphisms are known to affect significantly 1A2 activity: 1A2*1F which increase
metabolism and 1A2*1C which decrease it. These SNPs, located in the promoter region
of the gene, may be responsible of a different CYP1A2 mRNA expression and could
help to explain interindividual differences in enzyme activity. Aim of these research
was to evaluate the impact of these polymorphisms on CLO pharmacokinetics and on
the occurrence of adverse reactions (ADRs).
Methods: All enrolled subjects were patients treated with CLO in our department
during the period 2008-2009. Inclusion criteria for case-group were: diagnosis of
psychotic disorder, normal liver and renal function, absence of concomitant diseases,
occurrence of significant CLO-induced ADRs. Patients who assumed CYP1A2 inducer
or inhibitory drugs, except smoking, were excluded. We considered significant CLOinduced
ADRs all reactions which led to CLO discontinuation or a permanent dose
reduction, and were related to CLO according to the clinical evaluation of the clinicians
confirmed by a “certain” or “probable” result at WHO-Uppsala criteria (WHO Uppsala
Monitoring Centre-UMC: http://www.who-umc.org). In the control-group we enrolled
patients treated for at least 1 year with CLO without showing ADRs, with the same
clinical features, matched for age, sex, CLO doses and smoking habits. Clinical
parameters were correlated with the CYP1A2 genotype and allelic combinations and
with CYP1A2 mRNA expression levels.
Results: The ratings for side effects, like sedation, constipation, scialorrea, were
significantly higher in CYP1A2 poor metabolizers genotypes.
Conclusions: Treatment with clozapine could be dangerous in extremely slow
metabolizers and ineffective in extremely rapid. Although genotyping explained only a
fraction of the adverse events, it could be a good predictor of adverse events
Psichiatria e dermatoligia: 6 casi clinici di pazientiaffetti da schizofrenia e psoriasi.
No full textI vantaggi della rapidità d'azione di escitalopram: benessere soggettivo e funzionamento globale. Un caso clinico.
No full textAre adverse reactions to clozapina genetically predictable considering cytochrome P4501A2 haplotype?
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Association between CYP1A2 polymorphisms and clozapine-induced adverse reactions in patients with schizophrenia
No full textWe investigated the relationships between common polymorphisms in CYP1A2 (CYP1A2*1C and *1F), CYP1A2-mRNA levels in circulating lymphocytes and clozapine(CLZ)-induced adverse drug reactions (ADRs) in 34 patients. Patients with ADRs had a higher frequency of CYP1A2 low activity allele combinations (8/12; 67%) and lower CYP1A2-mRNA levels than patients without ADRs (6/22; 27%, P=0.019). © 2012 Elsevier Ireland Ltd
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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