1,721,121 research outputs found
Una proposta progettuale per il Rione Borgo. Rinnovo Urnano : il caso di Borgo a Roma. Contratto di Quartiere Borgo Pio.
No full textPiano-progetto per il recupero urbano di Borgo a completamento di una ricerca di Ateneo e di un Contratto di Quartiere "Roma-Borgo Pio"redatto in collaborazione con le diverse Amministrazioni locali interessate al programma di risanamento
Modelli di idoneità ambientale per Accipitriformi, Falconiformi e Strigiformi nella provincia di Verbania.
No full textDynamic changes in the functional profile of T-cell response to vaccination in PLWH
No full textPeople living with HIV (PLWH) are at increased risk to suffer from pneumonia and other respiratory diseases, some cancers and coinfections, and related complications are more common and persistent in this population. Furthermore, they may experience a higher burden of various comorbidities. For these reasons, they are often designated as a priority group for different vaccinations.
In general, the effective control of viremia with ART and a restored CD4 T cell count are correlated with an improvement of responsiveness to routine vaccines. However, efficacy of vaccines in this group is variable, due to the immunological changes and persistent immune dysfunctions that characterize the disease. In addition, the presence of comorbidities and coinfections may contribute to alter it.
In this work, we investigated the immune responses to two different vaccinations in the setting of HIV infection, emphasizing the quality of the T-cell response. This aspect of the immune response, that refers to the combination of functions that T-cells are able to exert, is not extensively studied, although a higher degree of multifunctionality has been associated with higher protection.
When I started my PhD, there was an urgent need to better characterize the immune response against the new mRNA-based vaccines against SARS-CoV-2 in vulnerable populations, including PLWH. In fact, the potentially worse outcomes of SARS-CoV-2 infections in this population and the risk that the vaccine-induced immune response to SARS-CoV-2 could be inferior or altered, has led the scientific community to pay great attention on this topic.
In addition, reports regarding the immune response in PLWH were not always in accordance, and information about the quality of T-cell response in this population was not available. Therefore, our study aimed to contribute to clarifying the knowledge gaps in the understanding of the quality, magnitude, and duration of immunity to SARS-CoV-2 vaccination in PLWH, aspects that are critical for the proper application of mitigation strategies, including additional dose strategies.
Collectively, our data supports that mRNA vaccination is able to elicit a humoral and cellular immune response against SARS-CoV-2 in most PLWH receiving ART, and that the booster dose enhanced the magnitude of these responses particularly among PLWH with a lower CD4 cell count. However, we found a particular signature in the functional profile of the T- cell response, that indicated a different quality of the response, with respect to the healthy donors.
During the second part of my PhD, thanks to an initiative aimed at implementing vaccinations in target populations with an active friendly vaccination offer methodology held at the SM Goretti Hospital, I had the opportunity to investigate the immune response to another vaccination, the vaccination against HPV.
For the primary prevention of HPV-related diseases, in 2014 the FDA approved Gardasil-9, an adjuvanted recombinant nonavalent vaccine, which recently, also has been introduced for the immunization of PLWH, regardless of age.
Since most studies focus on the antibody response and bivalent and quadrivalent vaccines, we decided to focus our attention on the characterization of the adaptive immune response to the nonavalent Gardasil vaccine in a cohort of PLWH on ART, with a focus on the functional profile of T cells.
Our study confirms that the vaccine is able to elicit a broad and coordinated immune response in our population, the benefits that people with a history of HPV infection might receive from vaccination and, finally, that PLWH with a lower current CD4 cell count remains a group who may not mount a fully protective immune response and, therefore, may require additional protection or ad hoc vaccination strategies.
Results from conducted research on two very different vaccines in two different settings of PLWH were presented and discussed. However, in our opinion, it’s possible to draw some final remarks.
Specific subgroups of PLWH can benefit from ad hoc immunization strategies, such as an adapted vaccine schedule, additional doses or use of adjuvants to improve immunological responses in order to achieve a proper level of immunization and, in this regard, the analysis of the functional profile of the T-cell response can represent a useful tool to capture some aspects of the immune response that may help guide us through this process
Borgo a Mozzano, Linea Gotica 1944
No full textBreve prefazione sul passaggio del fronte di guerra nella Campagna d'Italia a Borgo a Mozzano, fulcro della linea Gotica, nell'autunno 1944
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
LA POLIMIOSITE IN ETA' PEDIATRICA: PRESENTAZIONE DI TRE CASI CLINICI E REVISIONE DELLA LETTERATURA
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