1,720,986 research outputs found
Sister Mary Joseph's nodule from adenocarcinoma of the cecum. Report of a case.
No full textCutaneous metastases of malignant neoplasms are not common, occurring between 0,7 and 9 percent of autopsy evaluations. Those to the umbilicus, also known as Sister Mary Joseph'nodule, are even more rare and represent only 10 percent of all secundaries to the skin. These nodules usually arise from the gastrointestinal or genitourinary tract and may represent the first sign of a previously unknown primary tumor. This case demonstrates a Sister Mary Joseph' s nodule caused by an unknown primary cancer od the cecum
Umbilical metastases: current viewpoint
No full textAbstract Background Umbilical metastases from a malignant neoplasm, also termed Sister Mary Joseph's nodule, are not commonly reported in the English literature, and they have usually been considered as a sign of a poor prognosis for the patient. The present article reports on the current view point on umbilical metastasis besides discussing the epidemiology, clinical presentation, pathophysiology and treatment. Method A search of Pubmed was carried out using the term 'umblic*' and 'metastases' or metastasis' revealed no references. Another search was made using the term "Sister Joseph's nodule" or sister Joseph nodule" that revealed 99 references. Of these there were 14 review articles, however when the search was limited to English language it yielded only 20 articles. Articles selected from these form the basis of this report along with cross references. Results The primary lesions usually arise from gastrointestinal or genitourinary tract malignancies and may be the presenting symptom or sign of a primary tumour in an unknown site. Conclusion A careful evaluation of all umbilical lesions, including an early biopsy if appropriate, is recommended. Recent studies suggest an aggressive surgical approach combined with chemotherapy for such patients may improve survival.</p
Analysis of variables predictive of severity in biliary peritonitis
Full text linkObiettivo. Analizzare le caratteristiche cliniche ed i dati di laboratorio al fine di individuare i fattori prognostici negativi nelle peritoniti biliari (PB).
Pazienti e metodi. Analisi delle caratteristiche cliniche, decorso della malattia, dati di laboratorio e radiologici di 22 pazienti affetti da PB e successiva analisi statistica per valutarne il loro significato prognostico.
Risultati. Un decorso grave con prognosi infausta e associato a: età maggiore di 60 anni (P=0.034), maggior tempo intercorso tra inizio della sintomatologia e trattamento (P=0.025), febbre > 38°C (P=0.034), conta dei globuli bianchi maggiore di 17,000 cell/mm3 (P=0.043), dolore addominale diffuso (P=0.034) e presenza di bile infetta (P=0.048).
Conclusioni. Il decorso clinico di molti pazienti peggiora in seguito al verificarsi di una infezione; pertanto un rapido drenaggio della bile diminuisce la comparsa di serie complicanze. Inoltre, dolore addominale diffuso, febbre alta e marcata leucocitosi sono predittivi di una prognosi peggiore.
KEY WORDS: Biliary peritonitis - Bile drainage
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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