1,721,047 research outputs found
Two new indices for preventive conservation of the cultural heritage: Predicted risk of damage and heritage microclimate risk
No full textThe conservation and safeguarding of historic buildings, and of everything that is housed within them, represents a challenge whose value is currently shared at a world level. The conservation of these cultural assets depends on a number of variables, with the microclimate playing a decisive role among them. For at least two decades, scientific literature in the field has been reporting experiences on individual case studies relative to the study of the microclimate and criteria for the conservation of the cultural and architectural heritage, in this regard, standards have also been enacted. Nevertheless, in our view, the research involves stand-alone case studies that are not comparable among one another, in particular with regard to the risk assessment of the place where the assets are located and/or the damage that these assets may undergo as a result of the microclimate of their environment. In this contribution we intend to present two risk indices related to the microclimate: the Heritage Microclimate Risk (HMR) index, which defines the level of risk to which an indoor room is exposed, compared to maximum and minimum values defined according to standards or based on the historical microclimate; and the Predicted Risk of Damage (PRD) index, which links the value of the HMR with the risk of damage to a specific material/object, which is exhibited or conserved within the room. The HMR and PRD are determined by the microclimate variables monitored on site, in particular, Air Temperature and Relative Humidity, or they can be obtained by means of Building Simulation. The proposed indices make it possible to define the potential microclimate risk within a room, as well as the probability that these conditions can cause damage to the objects of value therein conserved (collections, paintings, etc.). As an example, we have reported the application of the two HMR and PRD indices to the case study of a hall of the Royal Palace of Venaria Reale in Turin (Italy)
Brain receptor binding and lipophilic character of benzodiazepines
No full textA series of measurements of the potency of 26 benzodiazepines (BDZs) to inhibit the binding of [3H]diazepam to rat brain synaptosomal membranes has been undertaken. All compounds studied are NO2 or Cl 7-substituted, a class of BDZs known to have the highest biological activities and binding affinities (expressed as Ki). The results show that: (a) 2′-unsubstituted BDZs display a parabolic dependence of -log Ki values on lipophilic character of the molecule (expressed by means of the chromatographic Rm value); (b) 2′-halogen substituted BDZs show quite high binding affinities (ki values in the range 2-5 nM) giving rise to another class of BDZs whose dependence on the lipophilic character remains to be studied; and (c) BDZs lacking the carbonyl oxygen at position 2 (see Table 1), and having an oxygen at position 4, show low or very low binding affinities (Ki values in the range 600-7000 nM). Moreover for the compounds under examination, statistically significant correlations have been obt..
High pressure liquid chromatographic determinations of feprazone in pharmaceutical formulations
No full textA high-pressure liquid chromatographic method was developed for the quantitative determination of feprazone, a nonsteroidal anti-inflammatory agent, in different pharmaceutical formulations. The results agree with those obtained with GLC and UV spectrophotometric assays
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Cholesterol esters of the liver, of the plasma and of the lipoproteins of rats poisoned with CCl4
No full textThe authors have pointed out that in rats poisoned by administration of CCl4 there is a total increase of the hepatic cholesterol esters 24 hours after the administration and a total reduction of the plasmatic cholesterol esters after only 4 hours. Among the cholesterol esters, those with higher degree of unsaturation appear to be more affected. Within the single lipoproteic classes, the most considerable variations involve the VLDL and the HDL. © 1979 The Italian Pharmacological Society
Historic Indoor Microclimate, the role of HVAC in heritage buildings' restoration: The case of the Palace of Venaria Reale
Full text linkThe vertical pattern of pigment concentrations in chloroplasts of Sphagnum capillifolium
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Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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