1,721,010 research outputs found
Real-time ultrasound elastography for assessment of response to brentuximab vedotin treatment in relapsed and refractory Hodgkin lymphoma.
No full textA case of thermal sink during liver Radiofrequency Thermal Ablation of an HCC adjacent to a large hepatic cystic lesion
No full textIn vivo RFTA of Small Breast Carcinoma
No full textBackground: Radio-frequency ablation (RFA) has
recently received much attention as an effective minimally
invasive strategy for the local treatment of tumors. The purpose
of this study was to evaluate the efficacy of single-needle cooltip
RF breast ablation in terms of temperature distribution and
duration of the procedure as compared to multiprobe RF
breast ablation. Materials and Methods: Two different
commercially available radiofrequency ablation needle
electrodes were compared. Finite-element method (FEM)
models were developed to simulate the thermoablation
procedures. A series of ex vivo radiofrequency thermal lesions
were induced to check the response of the FEM calculations.
Results: Data obtained from FEM models and from ex vivo
procedures showed that cool-tip RF breast ablation assures
better performances than multiprobe RF breast ablation in
terms of temperature distribution and duration of the
procedure. Histopathological analysis of the cool-tip RF
thermoablated specimens showed successful induction of
coagulation necrosis in the thermoablated specimens.
Conclusion: Data obtained from FEM models and from ex
vivo procedures suggest that the proposed cool-tip RF breast
ablation may kill more tumor cells in vivo with a single
application than the multiprobe RF breast ablation
Valutazione in vivo dei nervi ottici di pazienti glaucomatosi mediante Risonanza Magnetica con tensore di diffusione, confronto con gli indici del GDXvcc, dell’HRT3 e dell’OCT
No full text
Stress-induced increase in brain neuroactive steroids: antagonism by abecarnil
No full textAcute foot shock stress elicits a selective and time-dependent increase of neuroactive steroid (pregnenolone, progesterone, allotetrahydrodeoxycorticosterone) concentrations in rat brain cortex, accompanied by a marked increase of plasma corticosterone. The brain cortical neuroactive steroid levels peaked between 10 and 30 min poststress and returned to control values by 2 h. Abecarnil (0.3 mg/kg), i.p.), a beta-carboline derivative with anxiolytic properties, completely antagonized the effect of foot shock on brain cortical neuroactive steroids. A single administration of the anxiogenic beta-carboline FG 7142 (15 mg/kg, i.p.), in contrast, mimicked the effect of foot shock. These data support the hypothesis for the existence of a functional relationship between brain neuroactive steroid concentrations and GABAA receptor function/emotional state of the animal
Heat sink during radiofrequency ablation of a hepatocellular carcinoma abutting a large hepatic cystic lesion.
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
MR breast imaging: A comparative analysis of conventional and parallel imaging acquisition [RM delle mammelle: Confronto tra tecnica convenzionale ed imaging parallelo]
Full text linkPurpose. The objective of this study was to compare conventional breast magnetic resonance imaging (MRI) with breast MRI acquired with the sensitivity-encoding (SENSE) technique on a 1.5-T MRI scanner in the same patient, on the basis of image quality and kinetics analysis. Materials and methods. Thirty-one patients with suspicious mammography and US findings were included in the study. Conventional breast MRI consisted of the following sequences: T1 (matrix, 288x512); T2 (matrix 225x512); short tau inversion recovery (STIR) (matrix 320x224) and dynamic T1 [2D fast-field echo (FFE)] (matrix 256x512; temporal resolution =80 s). The SENSE technique included the following sequences: T1 (matrix 512x512); T2 (matrix 512x512); short-tau inversion recovery (STIR) (matrix 320x224); dynamic T1 (3D FFE) (matrix 512x512, with a temporal resolution ≤70 s). Image quality was graded on a four-point scale, and the mean scores given to each sequence were compared between the two protocols. The relative enhancement rates and the qualitative features of the signal intensity (SI)/time curves were also compared between the two protocols. Results. The readers found 64 contrast-enhanced lesions in 31 patients. Nineteen patients had a total of 27 malignant lesions. In the remaining 12 patients, 37 benign lesions were found. No significant differences between the two protocols were observed with regard to the mean relative enhancement rates and the qualitative features of the SI/time curves. In detail, the mean image quality scores were higher for SENSE imaging (p<0.05). The mean image quality score for the T1 and T2 morphological sequences were comparable. In contrast, the quality scores for the STIR images differed significantly between the two protocols (p<0.001), and a significant difference was also observed when comparing the T1 postcontrast images (p<0.001). Conclusions. Our data suggest that the SENSE imaging protocol applied in our study is superior to conventional imaging with regard to image quality, especially for T1 postcontrast and STIR images. SENSE imaging protocols may provide an alternative to conventional sequences for contrast-enhanced MRI of the breast using 1.5-T MR scanners. © 2008 Springer-Verlag
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