1,721,068 research outputs found
ngenol mebutate treatment in keloids. De Felice B, Guida M, Boccia L, Nacca M. BMC Res Notes. 2015 Sep 22;8:466. doi: 10.1186/s13104-015-1429-9.
No full textIngenol-mebutate has been used for the treatment of actinic keratosis. It has been shown that ingenol-mebutate inhibits the growth of cancer cells or induces tumor cell death through pro-apoptotic effects. Keloids are benign skin tumours and are the effect of a deregulated wound-healing process in genetically predisposed patients. Increased cell proliferation, which accounts for the progressive and hypertrophic nature of keloids, correlates with the failure of apoptosis and plays a role in the process of pathological scarring. Keloid cells show a mutated p53 gene resulting in functionally inactive p53 protein which cannot control genomic integrity. They tend to escape from apoptosis which leads to keloid development by means of accumulation of continuously proliferating cells. Currently, the treatment of keloids remains a challenge for high recurrence rates. However, the design and the development of pro-apoptotic therapeutic strategies would be beneficial to keloids treatment.
CASE PRESENTATION:
A 55-year-old caucasian woman presented recurrent keloids on a presternal scar. Standard surgical intervention was used to treat the scar. However, this was unsuccessful and a year later the patient sought treatment again, but only by alternative means as the patient refused further surgical intervention. Consequently, based on past research and experience, the authors attempted to treat these lesions with ingenol mebutate gel, due to the pro-apoptotic effects.
CONCLUSION:
After 1 month, there was a clinical resolution of lesions, with a slightly squamous, post-inflammatory erythema. A cutaneous biopsy proved the absence of residual keloids and deregulated expression of molecular markers. The last follow-up of the patient, 1 year after treatment, showed that the patient was still free of keloids recurrence
Innovative method for linking anthropisation process to vulnerability
No full textCoastal areas have been gradually modified by humans to face emerging social needs. This phenomenon can be traced in the Amalfi Coast (Southern Italy) through the presence of terraces, constructed to make its steep slope habitable and arable. The current research is aimed to investigate the anthropisation process in Minori, and to identify the most vulnerable areas where debris flows. Two photogrammetric datasets, acquired in 1956 and 2017, respectively, were processed to generate two fine resolution digital elevation models and orthophotos, applied to calculate the normalised remaining vegetation index, the digital elevation model of differences, the new vulnerability expeditious index. The two orthophotos were also classified by applying the OBIA approach for extracting terraced areas. An increment of 800% of man-made infrastructures was detected, while the extension and the location of terraces was not subjected to any transformation. This implies a strong increment of vulnerability in the Minori municipality
Tecnologie digitali per il supporto alla decisione e alla progettazione eco-orientata
No full textIl contributo riguarda l’esperienza di ricerca svolta dal laboratorio interdisciplinare LARP (Università Federico II) finalizzata a determinare potenziali scenari per la riqualificazione di terreni degradati e / o abbandonati. Sotto forma di saggio critico, il testo utilizza l’esperienza del caso studio per approfondire il tema della produzione della conoscenza per il progetto ambientale, individuando nell’utilizzo delle tecnologie digitali (telerilevamento, sistemi di informazione spaziale, software di valutazione multicriteria, piattaforme digitali, ecc) un fattore di innovazione nel
processo di supporto alla decisione. Il lavoro evidenzia anche i vantaggi di un approccio trasversale alla conoscenza, che serve a rafforzare una visione multisettoriale delle questioni ambientali
Valutazione dell'impatto della dermatite atomica sui pazienti in età pediatrica e sui loro caregiver
No full textNumerosi studi hanno evidenziato che la dermatite atopica (DA) dell’infanzia ha un impatto, oltre che sulla qualità della vita del piccolo paziente, anche su quella della sua famiglia. Questa ricerca è stata progettata allo scopo di valutare anche l’impatto della DA del bambino sullo stress psicofisico e sull’accordo di coppia del genitore-caregiver. Sono stati somministrati 4 questionari a 60 genitori-caregiver di bambini affetti da DA e 2 questionari a 60 genitori-caregiver di bambini sani. I risultati sono in linea con la letteratura scientifica, in più sono emersi nuovi dati relativamente all’impatto della DA sul genitore-caregiver del bambino affetto
Terraced landscapes located in areas of great value for touristic purposes as an irreversible practice
Full text linkSince Neolithic, terraced landscapes have been an essential element for moulding mountain or steep slope into habitable arable areas. Over the last decades, they have been subjected to a quick abandonment because of their inadequate economic competitiveness causing a gap in their maintenance and, consequently, incrementing the hydrogeological instability of those areas. Minori is a small municipality (256 ha), protected by UNESCO, located in Amalfi Coast. That area is well known not only for the beauty of its territory but also for some catastrophic raining events, like in 1954 when a rain shower of 500 mm topped up to 24 hours. The current research work intends to analyse the landscape changes in Minori over sixty year period (1956 - 2017) for assessing the new values taken on the land use and the agricultural sites. A detailed orthophoto and a high resolution Digital Elevation Model (DEM) of the study area have been reconstructed using the historical photogrammetric photos of 1954, acquired by the Italian Military Geographic Institute (IGM), and the aerial photogrammetric pictures of 2017, obtained by an own flight. DEM and orthophoto have been reconstructed applying Agisoft Photoscan Professional. The resolution of the generated DEM is equal to 0.48 and 0.1 m for 1956 and 2017, respectively. The orthophoto resolution is of 0.24 and 0.07 for 1956 and 2017, respectively. Comparing the generated products of the two periods, it is pointed out that terraces extension has not been amended, while the amount of human constructions have increased of about 800%. To give a first idea of the most vulnerable areas to be investigated more in depth through simulation procedures, a first proposal of an expeditious index of vulnerability (EVI) has been introduced and tested. It is based on the ratio between the amount of surface occupied by buildings and the amount of areas subjected to a debris flow event. The increase of the vulnerability, exposure values and probability of accident occurring involve a risk rise
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
A Dual Polarized Stacked Antenna for 5G Mobile Devices
No full textA stacked dual polarized antenna for future 5G mobile handsets is presented. Three square patches are realized on a stack of Rogers Duroid RT5880 substrates, and proper air gaps placed on the two lower patches determine the energy coupling. The feeding system consists of a couple of coaxial cable which provides the dual polarization in the same antenna. The results show a bandwidth from 26 to 28 GHz with more than 10 dB return loss for both polarizations and more than 18 dB isolation between the feeds. A directivity of over 9 dB is achieved over the whole operating frequency band for the copolar component of each polarization
- …
