1,721,023 research outputs found
Editorial: Recording and modulating neural activity in neurodegenerative diseases: Pathophysiological and therapeutic implications.
Full text linkNeurodegenerative diseases encompass different conditions characterized by progressive degeneration of neurons and networks and accumulation of misfolded proteins in the brain. Recent research employing invasive and non-invasive neurophysiological techniques provided new insights into pathological mechanisms responsible for symptom development. This set the foundation for the translation of advanced therapeutic neuromodulation strategies that hold promise to optimize symptom control and potentially modify disease course in the future. In this Research Topic, we aimed to investigate the role of specific neurophysiological abnormalities in neurodegenerative diseases that serve as electrophysiological target for invasive and non-invasive neuromodulation techniques, such as deep brain stimulation (DBS; Tinkhauser et al., 2017; Bocci et al., 2021) and transcranial alternating current stimulation (tACS; Benussi et al., 2022; Guerra et al., 2022). Parkinson's disease (PD) is an exemplary condition for targeting brain oscillatory activities for therapeutic purposes. Indeed, PD can be considered an oscillopathy, as abnormal oscillations at specific frequency bands in the basal ganglia-thalamo-cortical network play a relevant role in motor symptoms pathophysiology (Oswal et al., 2013). Not only the suppression of exaggerated oscillatory beta activity using DBS (Tinkhauser et al., 2017), but also driving the pro-kinetic high-gamma rhythm at the cortical level using non-invasive tACS may attenuate bradykinesia (Guerra et al., 2022)
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Iatrogenic Rhabdomyolisis and Guillain-Barre’ Syndrome: a Dangerous Association.
Full text linkGuillan-Barré Syndrome (GBS) is an acute, symmetrical polyneuropathy with a clinical manifestation of flaccid
paralysis with areflexia and variable sensory disturbance. GBS has an incidence of 1-2 cases/100.000 inhabitants
for year. The pathological spectrum of GBS includes Acute Inflammatory Demyelinating Polyneuropathy (AIDP),
Acute Motor Axonal Neuropathy (AMAN) and Acute Motor Sensory Axonal Neuropathy (AMSAN). We report a case
of an 81-year-old man with GBS (subtype AMSAN), secondary to a previous Micoplasma Pneumoniae infection, who
presented with an elevation of Creatin Kinase (CK) serum levels, and worsened by a co-administration of statins
and clarithromycin. By our knowledge there are few cases in the literature in which the association of these drugs
contributed to worsening GBS
Il ruolo dell'agopuntura nel controllo del dolore nella malattia di Parkinson: evidenze cliniche e strumentali
No full textE' stato valutato con scale cliniche e potenziali evocati laser l'effetto andidolorifico di un ciclo agopunturale in un paziente affetto da malattia di Parkinson con algie agli arti inferiori. E' stato documentato dopo un ciclo di sei sedute di agopuntura un miglioramento in tutte le scale cliniche e nei valori di ampiezza e latenza dei potenziali evocati lase
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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