1,968 research outputs found
Contribuição para o estudo acustico da sonoridade da consoante /R/ do frances realizada por estudantes brasileiros
No full textSubclinical hypothyroidism: summary of evidence in 2014
No full textSubclinical hypothyroidism, which is defined as elevated thyroid-stimulating hormone (TSH) levels with free thyroxine concentrations within the reference range, is a common disorder that increases with age and affects up to 18% of the elderly, with a higher prevalence in women compared to men. Prospective data have shown an increased risk of coronary heart disease events, heart failure, and cardiovascular mortality among affected adults. Conflicting results have been found on the association between subclinical hypothyroidism and cognitive impairment, depression and the risk of fractures. Management strategies including screening and treatment of subclinical hypothyroidism are still controversial, while the ongoing European randomised controlled trial "TRUST" targets to solve these uncertainties. This narrative review aims to assess current evidence on the clinical aspects, as well as screening and treatment recommendations in adults with subclinical hypothyroidism
Long-term Results of a 12-Week Comprehensive Ambulatory Cardiac Rehabilitation Program
No full textPURPOSE: To evaluate the long-term outcome of a 12-week outpatient cardiac rehabilitation (CR) program.
METHODS: In a prospective single-center interventional cohort study, 201 consecutive patients (133 patients after acute coronary syndrome, 32 patients after heart surgery, and 36 patients with heart failure) attending a 12-week comprehensive outpatient CR program were evaluated for exercise capacity, cardiovascular risk factors (CvRFs), and quality of life at entry, end, and 1.4 years after completion of the program (followup).
RESULTS: Physical exercise capacity improved significantly from program entry to program end and remained at this level at followup (P ≤ .006). CvRFs at followup were significantly reduced with regard to smoking prevalence and blood lipids (P < .001). At program end and followup, MacNew heart disease–specific emotional, physical, and social quality of life were improved significantly compared with those at program entry (P < .001). Use of cardioprotective medication remained equally high over the entire study period. However, significantly fewer patients reached blood pressure (<140/90 mm Hg, P = .034) and body mass index (<30 kg/m2, P = .017) goals at followup than at program end.
CONCLUSION: The 12-week comprehensive outpatient CR program was successful at reducing important CvRFs long-term
Manuel Kastel's Paradigm of the way of the Information of the Development and the Network Society
No full textThe author problematizes the contribution of Manuel Kastelo to the contemporary sociology and the foundation of the paradagim of the information development. The focus of this research is Kastel’s assumption of the origin of the network society and the process of the globalization of the world
A Cartographical Nightmare - Manuel de Godinho de Eredia's Search for India Meridional
No full textThe author examines the writings and maps of Manuel Godinho de Eredia from the early 1600s, and concludes that Eredia's "increasingly contradictory and far-fetched written and cartographical portrayals of India Meridional" should not be used to prove an earlier discovery of Australia
C-C bond cleavages of cyclopropenes: operating for selective ring-opening reactions
No full textThe author acknowledges the financial support from Agencia Estatal de Investigacion (AEI), Fondo Europeo de Desarrollo Regional (FEDER) and Ministerio de Economía y Competitividad (Grant No. CTQ2016-76840-R). The author thanks Dr. Pablo Barrio and Dr. Eva K. Schmitt for their kind revision of the manuscript. Unrestricted support from Prof. Dr. José Manuel González is also gratefully acknowledged. The ORFEO−CINQA network (CTQ2016-81797-REDC) is also kindly acknowledged
Identifying ground-robot impedance to improve terrain adaptability in running robots
No full text© The Author(s). To date, running robots are still outperformed by animals, but their dynamic behaviour can be described by the same model. This coincidence means that biomechanical studies can reveal much about the adaptability and energy efficiency of walking mechanisms. In particular, animals adjust their leg stiffness to negotiate terrains with different stiffnesses to keep the total leg-ground stiffness constant. In this work, we aim to provide one method to identify ground-robot impedance so that control can be applied to emulate the aforementioned animal behaviour. Experimental results of the method are presented, showing well-differentiated estimations on four different types of terrain. Additionally, an analysis of the convergence time is presented and compared with the contact time of humans while running, indicating that the method is suitable for use at high speeds.This work was partially funded by the Spanish National Plan for Research, Development and Innovation through grant DPI2013-40504-R. Mr. Juan Carlos Arevalo and Mr. Manuel Cestari would like to thank the Spanish National Research Council and the Spanish Ministry of Economy and Competitiveness for funding their PhD research.Peer Reviewe
Crowdsourcing contest dilemma
No full textCrowdsourcing offers unprecedented potential for solving tasks efficiently by tapping into the skills of large groups of people. A salient feature of crowdsourcing—its openness of entry—makes it vulnerable to malicious behaviour. Such behaviour took place in a number of recent popular crowdsourcing competitions. We provide game-theoretic analysis of a fundamental trade-off between the potential for increased productivity and the possibility of being set back by malicious behaviour. Our results show that in crowdsourcing competitions malicious behaviour is the norm, not the anomaly—a result contrary to the conventional wisdom in the area. Counterintuitively, making the attacks more costly does not deter them but leads to a less desirable outcome. These findings have cautionary implications for the design of crowdsourcing competitions
Functional health and white matter hyperintensities as effect modifiers of blood pressure-lowering on cognitive function and vascular events in older Secondary Prevention of Small Subcortical Strokes trial participants.
No full textOBJECTIVE
To determine whether cerebral small vessel disease or disability modify the effect of SBP treatment on cognitive and vascular outcomes in older patients with recent lacunar stroke.
METHODS
Participants aged at least 65 years of the Secondary Prevention of Small Subcortical Strokes Trial were randomized to a higher (130-149 mmHg) or lower (<130 mmHg) SBP target. The primary outcome was change in cognitive function (Cognitive Abilities Screening Instrument); secondary outcomes were incident mild cognitive impairment, stroke, major vascular events (all-stroke, myocardial infarction), and all-cause death. Results were stratified by severity of white matter hyperintensities (WMH; none/mild, moderate, severe) on baseline MRI, and by disability (no vs. at least one limitation in activities of daily living).
RESULTS
One thousand, two hundred and sixty-three participants (mean age 73.8 ± 5.9 years, 40% women) were included. Participants with severe WMH or disability had worse cognitive function at baseline and after a mean follow-up of 3.9 years. No significant interactions existed between treatment group and effect modifiers (WMH, disability) for change in cognitive function (P for interaction 0.42 and 0.66, respectively). A lower SBP target appeared more beneficial among those with worse WMH burden for vascular outcomes (P for interaction = 0.01 for stroke and 0.03 for major vascular events).
CONCLUSION
There was no difference in the effect of lowering SBP to less than 130 mmHg on cognitive function by cerebral small vessel disease or disability among older adults with a history of lacunar stroke. Those with evidence of small vessel disease may derive greater benefit from lower SBP on prevention of subsequent vascular events.
TRIAL REGISTRATION
Clinicaltrials.gov Identifier: NCT00059306
Beam-ACO Based on Stochastic Sampling: A Case Study on the TSP with Time Windows
No full textProceedings of LION 3 - 3rd International Conference on Learning and Intelligent Optimizationinfo:eu-repo/semantics/publishe
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