1,721,398 research outputs found
Regio- and Stereoselective Ring Opening of Hetero Diels-Alder Cycloadducts with Organometallic Reagents
No full textEvaluation of the application of bovine, ovine and caprine SNP chips to dromedary genotyping
No full textThe lack of SNP arrays for less traditional livestock species has led researchers to explore the possibility of applying the use of commercial SNPs already detected in other related livestock species. For example, the medium density bovine and ovine SNP chips have been successfully used to detect polymorphic SNPs in several other species. The dromedary camel belongs to the Camelidae family and represents an important source for production of milk, transportation and meat in several countries. Until now, no SNP chip has been developed for the dromedary and genome information is still incomplete when compared to other livestock species. In this study, 8 to 17 dromedary samples were genotyped using 3 different ruminant species SNP chips: the Bovine 777K SNP BeadChip, the Ovine 600K SNP BeadChip, and the Caprine 50K SNP BeadChip. The quality of hybridization was assessed considering the average value between the 10%GC and the 50%GC (averageGC) scores and the call rate. Only SNPs with averageGC >0.70 and call rate=1.0 were considered. A total of 29,900 Bovine and 14,179 Ovine SNPs were considered successfully genotyped while none of the Caprine SNPs were qualified for further analysis. Among these SNPs, only 27,585 for the bovine and only 88 for the ovine were polymorphic in our dromedary dataset. These SNPs could represent the first step towards the development of a SNP chip useful for this camelid species after appropriate validations
Preparazione ortodontica parziale nel trattamento combinato ortodontico-chirurgico del progenismo
No full textUnexpected Response to Nivolumab in a "fast Progressor" Head and Neck Cancer Patient
Full text linkPrior to the advent of immune checkpoint inhibitors targeting PD-1/PD-L1 axis no drug demonstrated to improve survival or quality of life in the second-line treatment of recurrent or metastatic head and neck squamous cell carcinoma (R/M-HNSCC). Nivolumab appear to have a clear clinical benefit for R/M-HNSCC, based on improved survival, good toxicity profile, reduction in symptoms and improvement in overall quality of life. This benefit seems to be greater for PD-L1 positive patients and independent of previous treatment, even being observed among heavily pre-treated patients. However, even in responding tumors acquired resistance to nivolumab usually occurred, limiting the drug's activity. We report a case of unexpected prolonged stable disease in second-line treatment with nivolumab after a rapid progression disease under first-line chemotherapy in biomarker-positive R/M-HNSCC
Estetica nella storia dell'arte e nella sensibilità contemporanea. Parte I: I canoni egizio e greco-romano.
No full textEstetica nella storia dell'arte e nella civiltà contemporanea. Parte II: Icanoni rinascimentali e moderni.
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