1,720,965 research outputs found
The papillary arterio-venous passage time (PAVPT) in normal subjects and in glaucomatous eyes
No full textAngiography of the optic nerve head and of the peripapillary area.
No full textVolume Monografia in lingua ingles
Frame by frame dilution analysis of ICG angiography: a new method to measure choridal blood flow in glaucoma
No full textPurposes: To identify a new method of choroidal blood flow analysis in glaucomatous
patients. Methods: Twenty-four glaucomatous patients (G), 15 subjects with normal
tensional glaucoma (NTG) and 26 age-matched controls were recruited for the study.
They were submitted to dynamic indocyanine green angiography (ICGA) with a scanning
laser ophthalmoscope (SLO) (Rodenstock, Munchen, Germany). The choroidal filling
phases were digitized and stored in a computer. Twenty-five frames per second were
obtained. Each frame was elaborated by means of a “ threshold technique ” in order to
obtain black or white pixels. The area occupied by the white pixels in a field of 35° of
the choroid surrounding the disc was measured. The data obtained from each frame
were plotted versus time in order to obtain a “ frame-by-frame ” dilution curve. The 10%
filling time and the 55% filling time were compared among the three groups. Results:
NTG and G groups showed a significantly delayed filling time of the posterior choroid
when compared to the controls (10% filling time, p<0.01; 55% filling time, p<0.05). No
statistical difference between NTG and G could be observed. Conclusions: These data
suggest that an altered choroidal blood flow can play a role in the pathogenesis of
glaucoma.
CR: None -
Functional effects of scatter macular photocoagulation for age-related subfoveal neovascularization
No full textFluorescein and ICG angiographic findings in serpiginous choroidopathy
No full textPlnRIfn- To analyze the fluorescein (FA) and indocyanine green (ICGA) angiographic
aspects of serpiginous choroidopathy. Msfhndl- We performed FA and ICGA in 11 consec-
utive paOents with serpiginous chowidopathy with a SLO (Rode[Istock, Germany) and with
a still-frame digitized fundus camera (Topcon 50 IA, japan). llflnlfl- In 6 patients the dis-
ease was active (12 eyes), in other 5 (10 eyes) it was inactive and 2 of these patients (3 eyes)
had developed a choroidal neovascularization. The active lesions were hypofluorescent in
Che early phases of the FA showing diffusion in the late phase!s. In 2 of the patients with
active disease a retinal vasculitis was also present. The healed lesions were hypofluorescent
in the early phase of the FA due to extensive atrophy of the chodocapillaris and choroidal
vessels with sparing of major collors. A progressive hypernllorescence of the margins
was also apparent. In ICGA in the active stage the lesions were hypo8uorescent throughout
the examination. In 4 of the 6 patients with active disease the ICGA revealed a delayed cho
roidal 6lling next to the active lesions. FoHow up showed in only one subject a coinddence
between the delayed choroidal filling and the progression of the lesions.fnllfhlllSlN - FA
and ICGA are useful to highlight the level of activity of the disease and the extent of the cho-
roidal damage but it cannot precisely predict the evolution of the lesions.
CR: Non
Photodynamic therapy (PDT) increases the eligibility for feeder vessel (FV) treatment of choroidal neovascolarization (CNV) due to age-related macular degeneration (ARMD)
No full textPurpose: PDT has been proven to be beneficial in reducing the risk of severe visual loss
in selected patients with ARMD complicated by subfoveal CNV. One of the major draw-
backs of PDT is the high rate of persistence and/or recurrences and the frequent re-treat-
ments needed to achieve a permanent closure of CNV. Recently, the treatment of the
vessel that nourishes the CNV (i.e. the FV) has been proposed as an alternative rational
approach. However, the rate of identification of the FV in newly formed CNV, is about 20-
25% The aim of this study was to evaluate if previous PDT can improve the detection of
the FV in patients with ARMD and subfoveal CNV. Methods: One-hundred-fifty-six eyes of
145 patients affected by ARMD complicated by subfoveal CNV were selected for PDT with
Verteporfyn. They matched the clinical criteria for the eligibility to PDT with predomi-
nantly classic CNV. Before treatment each patient underwent both fluorescein (FA) and
indocyanine, green dynamic angiography CICGA) with a Rodenstock scanning laser oph-
thalmoscope. Results: With ICGA 35 eyes out of 156 C22.4%) showed evidence of one or
mom arterial choroidal FVs. All eyes were treated with PDT. After 3 months all patients
repeated FA and ICGA. One-hundred-thirty-three eyes (85.2%) showed persistence of the
CNV associated to early and late leakage of fluorescein. In 112 eyes out of 133 CS4.2%)
dynamic ICGA allowed identifying one or more choroidal arterial FVs. Sixteen patients
refused the second PDT. In these eyes FV closure was then applied with a yellow thermal
laser. .Dynamic ICGA was then performed 1 day, 1 week, 1 month, 3 and 6 months after
FV treatment Two eyes needed retreatment of the FV. In one eye a new FV appeared.
One eye, despite repeated attempts, a subfoveal CNV with a patent FV persisted. Conclusion: These preliminary observations show (i) that previous PDT can improve the identi-
flcation of the FV in patients with ARMD and subfoveal CNV and (ii) that a combined
approach (PDT and FV closure) can be considered in order to reduce the need of repeated
PDT treatments.
CR: Non
The effect of external eye irradiation on choroidal circulation.
No full textBackground : The effect of external beam radiation therapy (teletherapy) on the choroidal circulation is poorly known. Eyes irradiated with teletherapy represent a good model to study, without confounding factors, the pathophysiologic and clinical aspects of radiation-induced chorioretinal damage. This study used fluorescein and indocyanine green choroidal angiography to investigate the late effects of external eye irradiation on the choroidal circulation. Methods : Fluorescein angiography and indocyanine green choroidal videoangiography were performed on patients with radiation retinopathy because of external eye irradiation for orbital and paranasal sinus malignancies. Patients were divided into two groups according to the treatment field (anterior unilateral or bilateral). Results : Indocyanine green angiograms showed areas of choriocapillaris hypoperfusion in all eyes-unilateral or bilateral irradiation-affected by radiation retinopathy. Late indocyanine green choroidal staining was found in five eyes (28%) of the patients who received unilateral anterior irradiation. In the same group, nine eyes (52%) had signs of choroidal precapillary occlusion and four eyes (23%) had rubeosis iridis without retinal neovascularization. One case of subfoveal choroidal neovascularization was documented in the bilateral irradiation group. Conclusions : Radiation side effects are not limited to the retinal vessels but also involve choroidal circulation. The damage to the choroid is primarily vascular, and its clinical aspects depend on the treatment fields. Anterior irradiation may be a critical factor for the appearance of unusual rubeosis iridis and neovascular glaucoma
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Perilesional satellite dark dots in toxoplasmic retinochoroiditits as revealed by indocyanine green angiography
No full textPurpose To analyze the indocyanine green angiographic aspects of toxoplasmic
retinochoroiditis
Methods: We performed fluorescein and indocyanine green angiography in 5 consecutive
patients with toxoplasmic retinochoroiditis; three of the five patients had acute disease,
while in the other two the disease-was inactive.
Results: Indocyanine green angiography showed satellite dark dots in 2 of the 3 patients
with acute toxoplasmic retinochoroiditis. These lesions were not visible in fluorescein
angiography. In the third patient with acute toxoplasmic retinochoroiditis, primary chori-
oretinal focus was juxtapapillary. None of the 2 patients in inactive phase showed similar
features.
Concluions: Indocyanine green angiography is useful to highlight the real extent of
RP-choriocapillary complex involvement in the acute toxoplasmic retinochoroiditis. A
different RPE-choriocapilllary complex response may be hypothesized based on the site of
the primary lesion.
CR: None Snppoft: Fondazione GB Bietti per L’Oftalmologia (GBB
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