1,721,076 research outputs found
Electrochemotherapy of head and neck cancer
No full textIn the head and neck area, electrochemotherapy (ECT) is currently implemented for the treatment of recurrent and/or metastatic cutaneous, subcutaneous, mucosal, or deep-seated tumors of any kind of histology. However, its particular efficiency in the treatment of small, primary, and treatment-naïve tumors has already been demonstrated. Nevertheless, ECT has different effectiveness in tumors of various histotypes. Basal cell carcinomas proved to be a most responsive tumor with almost 100% objective response rate and excellent cosmetic results without any functional impairment of treated sites. For the treatment of deep-seated tumors in the head and neck region, long single needle electrodes are used. These electrodes can be placed in various patterns with the aim to cover large and irregular-shaped tumors, hidden under the visible surface. Moreover, coupling treatment planning and navigation system enables precise insertion of long, single needle electrodes into deep-seated tumors of the head and neck region. Further developments in the application of ECT in the head and neck cancers are orientated to reduced dose of bleomycin in elderly patients and combining ECT with immunotherapy and/or immunogene electrotransfer
Advanced seismic design of a steel fitness centre including a dissipative bracing system
Full text linkA dissipative bracing technology incorporating pressurized fluid viscous
spring-dampers is adopted as anti-seismic design strategy of a fitness centre steel
building. This represents the first simulated application of the considered protection
system, originally conceived and set up for use in multi-story frame structures, to a
slender and lightweight building. The characteristics of the spring-dampers and the
protective system are recalled, and the performance-based structural design of the
building is described. The resulting dimensions of members, as well as the total
weights and costs of the steel structure are compared with the ones of a conventional
X-shaped bracing solution, complimentarily designed to provide the same performance.
A 50% net reduction of costs and an improved aesthetics of the structure, due to
the remarkably greater slenderness of the constituting members, come out for the dissipative
bracing-based design
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Early microscopic evidence for endothelial damage in arterial microanastomoses
No full textThrombosis of the arterial microanastomosis is the major reason for flap complications. Thrombus formation can occur rapidly at the site of anastomosis, or it may be delayed in developing, inducing secondary ischemia. The damaged endothelial cells and the exposed connective tissue play an important role in the molecular and cell mechanisms of coagulation and thrombosis. For this reason the early morphological changes in the endothelial cell layer after arterial microanastomoses in the rat were investigated. The results showed that the anastomotic site appeared completely sealed, with cut ends protruding into the vessel lumen. Extensive deendothelialized areas with fibrin deposition were visible between surgical microclamps on the inner surface of the artery. For this reason we believe that the damaged endothelium and exposed connective tissue elements are the primary cause of thrombin formation, platelet accumulation, and thrombosis at the anastomotic site. The reconstructive surgeon must employ a very meticulous microvascular technique to minimize damage to the vascular endothelium
Dynamic behavior of the Provox and Staffieri prostheses for voice rehabilitation following total laryngectomy
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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