1,720,982 research outputs found
“La valutazione multidimensionale nell’anziano con scheda Val.Graf. Friuli Venezia Giulia”
No full textIdentification of novel non-myelin biomarkers in multiple sclerosis using an improved phage-display approach
Full text linkAlthough the etiology of multiple sclerosis is not yet understood, it is accepted that its pathogenesis involves both autoimmune and neurodegenerative processes, in which the role of autoreactive T-cells has been elucidated. Instead, the contribution of humoral response is still unclear, even if the presence of intrathecal antibodies and B-cells follicle-like structures in meninges of patients has been demonstrated. Several myelin and non-myelin antigens have been identified, but none has been validated as humoral biomarker. In particular autoantibodies against myelin proteins have been found also in healthy individuals, whereas non-myelin antigens have been implicated in neurodegenerative phase of the disease. To provide further putative autoantigens of multiple sclerosis, we investigated the antigen specificity of immunoglobulins present both in sera and in cerebrospinal fluid of patients using phage display technology in a new improved format. A human brain cDNA phage display library was constructed and enriched for open-read-frame fragments. This library was selected against pooled and purified immunoglobulins from cerebrospinal fluid and sera of multiple sclerosis patients. The antigen library was also screened against an antibody scFv library obtained from RNA of B cells purified from the cerebrospinal fluid of two relapsing remitting patients. From all biopanning a complex of 14 antigens were identified; in particular, one of these antigens, corresponding to DDX24 protein, was present in all selections. The ability of more frequently isolated antigens to discriminate between sera from patients with multiple sclerosis or other neurological diseases was investigated. The more promising novel candidate autoantigens were DDX24 and TCERG1. Both are implicated in RNA modification and regulation which can be altered in neurodegenerative processes. Therefore, we propose that they could be a marker of a particular disease activity state
Infant directed speech and frontal lobe
No full textSaito et al.1 showed, by means of a two channel NIRS, a differential response of the neonatal brain to maternal Infant Directed Speech (IDS), in comparison to Adult Directed Speech (ADS). Their study is very interesting. They hypothesize that a newborn is able to distinguish between different emotional communications in the first days of life. These results reignite the discussion on early predisposition for newborns’ recognition of their mothers, and on how early relational skills in newborns correlate with fetal learning abilities in the intrauterine environment
Infant Directed Speech and Frontal LobesElectronic letter 19 ottobre 2007.
No full textSaito et al.1 showed, by means of a two channel NIRS, a differential response of the neonatal brain to maternal Infant Directed Speech (IDS), in comparison to Adult Directed Speech (ADS). Although this is a fascinating research, we would obviously agree with statements such as “IDS functions as a positive stimulation for the emotional development of infants” but at the same time consider rather premature on the scarce data available, and even more so about the suggested functional lateralization for IDS (emotional) processing in the neonatal brain. A multichannel NIRS system, such as the Optical Topography, is needed to detect the distribution of cortical activation. Improved spatial resolution is required in mapping cerebral regions involved in complex functions such as emotional expression
Matching the brain affective systems in young and elderly people: a possible neural supported development of human personality during life span
No full text“Clinical implications of the “Affective Neuroscience Personality Scales”: the assessment of depression in elderly”
No full textThe use of optical topography for the study of cortical cerebral emotional learning functions
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“Maternal empathy to infant pain: a pilot study by means of optical topography on the prevention of postpartum depression”
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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