24 research outputs found
Reflusso gastroesofageo (RGE) nei pazienti portatori di malattie parenchimali diffuse del polmone (DLDS)
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Does Technetium-99m Diethylenetriaminepentaacetate Clearance Predict the Clinical Course of Idiopathic Pulmonary Fibrosis?
No full textClearance of inhaled technetium-99m diethylenetriaminepentaacetate (99mTc-DTPA) is a potential indicator of disease activity and progression in idiopathic pulmonary fibrosis (IPF). The objective of the present study was to evaluate the prognostic value of 99mTc-DTPA scans in IPF. A total of 22 patients (18 males), aged 33 to 80 years with IPF were followed for six to 20 months (mean 13 months). At diagnosis, high resolution computed tomography (HRCT) scans showed a honeycomb pattern with bibasilar reticular opacities in all cases. At T0 (diagnosis) and T1 (follow-up), each patient had pulmonary function tests (forced vital capacity, diffusing capacity of the lung for carbon monoxide and partial arterial O2 pressure), extension of fibrosis evaluated by HRCT visual score and 99mTc-DTPA lung clearance. Results at T0 and T1 were compared, taking into account the whole population and patients with relatively fast and slow 99mTc-DTPA wash-out. 99mTc-DTPA clearance did not show any significant correlation with functional tests or HRCT score. These findings indicate that clearance of inhaled 99mTc-DTPA is not of value in following the progress of IPF
Inflammatory activity is still relevant in advanced stage of idiopathic pulmonary fibrosis.
No full textAbout a Non-Linear Mathematical Model for Alveolar Diffusion
No full textThis mathematical model of the alveolar diffusion, computer processed, establishes the relationship between the lung diffusion capacity and a representative physical property of the alveolar region termed effective diffusity. The boundary conditions influence the lung diffusing capacity. This fact makes the lung diffusing capacity, measured clinically via the single breast test, to be a parameter sufficient only to establish a diffusion abnormality, but insufficient for distinguishing among different reasons of respiratory diseases
