1,720,976 research outputs found
Characterization of phyllosilicates for pharmaceutical and cosmetic uses
No full textThree mineral clays were characterized in order to establish their suitability in pharmaceutical and cosmetic fields
Citotossicità e uptake di un microsistema per la somministrazione orale di tamoxifene
No full textMicroparticelle di alginato, reticolato con ioni calcio e chitosano, caricate con Tamoxifene sono state sottoposte a test di citotossicità e a test di uptake cellulare. La citotossicità è funzione del tipo di alginato che può diminuire l'attività del principio attivo. Le microparticelle presentano uptake cellulare
Montmorillonite as drug delivery system for gentamicin
No full textClays are common ingredients in pharmaceutical and cosmetic formulations as active substances (gastrointestinal protectors, osmotic oral laxatives, antidiarrhoeaics, topical antibacterials and antinflammatories) and excipients in solid forms (tablet, capsules, powder), liquid forms (suspensions, emulsions) or semisolid forms (ointments, creams). Only some clay minerals, a combination of Al or Mg octahedra and Si tetrahedra (phyllosilicates), including kaolin, talc, smectites and fibrous clays have beneficial effects in dermatological and cosmetic applications (geotherapy, palotherapy) according to their rheological and thermal properties as well as cation exchange capacity (CEC) and absorption. More, the intercalation of several drugs or cosmetic substances in smectites could represent an advantageous approach to design delivery systems for the topical use. Clay-drug interaction affects the properties of both the dosage form (viscosity, flow property) and the intercalated drug (stability , release, absorption).Among the mineral clays, montmorillonite (MMT) has high specific surface area and it exhibits good adsorption ability, cation exchange capacity, standout adhesive ability and drug-carrying capability. As a result of clay structural and chemical characteristics, montmorillonite, a 2:1 (ratio of silica tetrahedra to aluminium and/or magnesium octahedra) layered silicate, can accomodate therapeutic compounds between the layers generating a host for oral and topical drug delivery.The present work aims to evaluate the intercalation of gentamicin molecules into MMT clay to obtain a modulating drug delivery carrier for antibiotic skin treatment. More, clay antibacterial activity could produce a synergistic effect.The intercalation process of gentamicin into the MMT interlayer at different pH value and drug concentration was examined. MMT-gentamicin hybrid was characterized by X-ray diffraction, Fourier transformed infrared, ultraviolet-visible spectroscopy, thermal analysis, differential scanning calorimetry and molecular dynamics simulation
L'acqua e le argille della miniera di Piloni di Torniella (GR) nella peloidocosmesi
No full textDue tipi di caolino provenienti dalla miniera di Piloni di Torniella sono stati caratterizzati dal punto di vista chimico, mineralogico, microbiologico e tecnologico per un loro eventuale impiego in campo cosmetologico
Characterization of gentamicin-bentonite complex
No full textClays are common ingredients in pharmaceutical and cosmetic formulations, used as active substances (gastrointestinal protector, osmotic oral laxatives, antidiarrhoeaics, topical antibacterials and antinflammatories) and excipients in solid (tablet, capsules, powder), liquid (suspensions, emulsions) or semisolid (ointments, creams) forms.Among the mineral clays, bentonite (BNT) has high specific surface area and it exhibits good adsorption ability, cation exchange capacity, standout adhesive ability and drug-carrying capability.The present work aims to evaluate the intercalation of gentamicin molecules into BNT clay to obtain a drug delivery carrier for antibiotic treatment in a perspective to decrease gentamicin side effects and to improve systemic adsorption.More, clay antibacterial activity could produce a synergistic effect.BNT-gentamicin hybrid was characterized by X-ray diffraction, Fourier transformed infrared, ultraviolet-visible spectroscopy, thermal analysis, differential scanning calorimetry and simulations molecular dynamics modelling.Molecular modeling can suggest an interaction between bentonite and gentamicin molecules producing a monolayer in the montmorillonite (the main mineral composing bentonite) interlayer; adsorbed gentamicin is hydrated having, probably, water molecules located between the siloxane surface and gentamicin molecules with a resulting layer periodicity of 14.22 Å.The result obtained demonstrated the ability of gentamicin to be intercalated within the BNT structure
Montmorillonite as efficient carrier of gentamicin used for antibiotic treatment: comparison of MD simulations with experiments
No full textThe presented work shows the potential of a montmorillonite-based clay mineral (bentonite) to contribute to the development of novel antibiotic materials. In our knowledge, it is the first time the have been tested the intercalation of gentamicin molecules in montmorillonite as a drug delivery carriers for antibiotic treatment.Comparison of experimental measurements (XRD, TGA, DTA) with simulations (MD modelling) have provided a more detailed understanding of the geometry, organization of gentamicin molecules confined in the cationic clay. By MD simulations it has been possible obtain a further insight into the interactions between the organic guest and the clay framework in view to optimize the cationic exchange process
In vitro and in vivo skin permeation of glycolic acid
No full textEvaluation in vitro skin permeation of glycolic acid from two different skin formulation and comparison the in vitro data with those obtained in vivo by means tape-stripping technique in humans. As far as the vehicle influence, in vivo glycolic acid skin permeation extent was predicted by the in vitro data. On the contrary, the in vitro assay provided an overestimation of absorption that can be probably explained by glycolic acid penetration into the unremoved stratum corneum layers
Valutazione in vivo di micro- e nanocarrier lipidici per uso dermocosmetologico
No full textE' stata determinata la permeazione attraverso lo strato corneo di micro- e nanoparticelle di natura lipidica (liposfere, Solid Lipid Nanoparticles) veicolanti beta-carotene e titanio biossido, quali marker, mediante stripping test. Le microparticelle non attraversano la struttura cornea, mentre le nanoparticelle sono risultate in grado di attraversare la barriera cornea
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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