13 research outputs found
Analysis of E-Exams performance under COVID-19 Pandemic at Kabale University, Uganda
No full textThere has been a shift in a mode of conducting exams from physical appearance of students to the electronic examinations due to covid-19 pandemic. This paper presents the experience in the management of e-exams as part of the summative evaluation of students. This was achieved by establishing the readiness strategies for managing e-exams, determining the performance of e-exams management and ascertaining the challenges faced during the management of e-exams.Kabale Universit
Smart Discharges Uganda Under 5: Phase I clinical data of children 6-60 months
No full textThis data is a subset of the Smart Discharges Uganda Under 5 years parent study and is specific to the Phase I observational cohort of children aged 6-60m.
Objective(s): Used as part of the Smart Discharge prediction modelling for adverse outcomes such as post-discharge death and readmission.
Data Description: All data were collected at the point of care using encrypted study tablets and these data were then uploaded to a Research Electronic Data Capture (REDCap) database hosted at the BC Children’s Hospital Research Institute (Vancouver, Canada). At admission, trained study nurses systematically collected data on clinical, social and demographic variables. Following discharge, field officers contacted caregivers at 2 and 4 months by phone, and in-person at 6 months, to determine vital status, post-discharge health-seeking, and readmission details. Verbal autopsies were conducted for children who had died following discharge. .
Data Processing: Created z-scores for anthropometry variables using height and weight according to WHO cutoff. Distance to hospital was calculated using latitude and longitude. Extra symptom and diagnosis categories were created based on text field in these two variables. BCS score was created by summing all individual components.
Limitations: There are missing dates and the admission, discharge, and readmission dates are not in order.
Ethics Declaration: This study was approved by the Mbarara University of Science and Technology Research Ethics Committee (No. 15/10-16), the Uganda National Institute of Science and Technology (HS 2207), and the University of British Columbia / Children & Women’s Health Centre of British Columbia Research Ethics Board (H16-02679). This manuscript adheres to the guidelines for STrengthening the Reporting of OBservational studies in Epidemiology (STROBE).NOTE for restricted files: If you are not yet a CoLab member, please complete our membership application survey to gain access to restricted files within 2 business days.
Some files may remain restricted to CoLab members. These files are deemed more sensitive by the file owner and are meant to be shared on a case-by-case basis. Please contact the CoLab coordinator on this page under "collaborate with the pediatric sepsis colab.
Smart Discharges Uganda Under 5: Phase I clinical data of children 0-6 months - pulse oximetry
No full textThis data is a subset of the Smart Discharges Uganda Under 5 years parent study and is specific to the Phase I observational cohort of children aged 0-6 months containing pulse oximetry data.
Background: Substantial mortality occurs after hospital discharge in children under 5 years old with suspected sepsis. This study aimed to refine and externally validate a previously developed post-discharge mortality prediction model.
Methods: In this prospective observational cohort study, we recruited 0-6-month-old children admitted with suspected sepsis from the community to the paediatric wards of six Ugandan hospitals. The primary outcome was six-month post-discharge mortality among those discharged alive.
Data Collection Methods: All data were collected at the point of care using encrypted study tablets and these data were then uploaded to a Research Electronic Data Capture (REDCap) database hosted at the BC Children’s Hospital Research Institute (Vancouver, Canada). At admission, trained study nurses systematically collected data on clinical, social and demographic variables. Following discharge, field officers contacted caregivers at 2 and 4 months by phone, and in-person at 6 months, to determine vital status, post-discharge health-seeking, and readmission details. Verbal autopsies were conducted for children who had died following discharge.
Ethics Declaration: This study was approved by the Mbarara University of Science and Technology Research Ethics Committee (No. 15/10-16), the Uganda National Institute of Science and Technology (HS 2207), and the University of British Columbia / Children & Women’s Health Centre of British Columbia Research Ethics Board (H16-02679). This manuscript adheres to the guidelines for STrengthening the Reporting of OBservational studies in Epidemiology (STROBE).NOTE for restricted files: If you are not yet a CoLab member, please complete our membership application survey to gain access to restricted files within 2 business days.
Some files may remain restricted to CoLab members. These files are deemed more sensitive by the file owner and are meant to be shared on a case-by-case basis. Please contact the CoLab coordinator on this page under "collaborate with the pediatric sepsis colab.
Smart Discharges Uganda Under 5: Phase II clinical data of children 6-60 months - pulse oximetry
No full textThis data is a subset of the Smart Discharges Uganda Under 5 years parent study and is specific to the Phase II interventional cohort of children aged 6-60 months containing pulse oximetry data.
Background: Substantial mortality occurs after hospital discharge in children under 5 years old with suspected sepsis. This study aimed to refine and externally validate a previously developed post-discharge mortality prediction model.
Methods: In this prospective observational cohort study, we recruited 0-6-month-old children admitted with suspected sepsis from the community to the paediatric wards of six Ugandan hospitals. The primary outcome was six-month post-discharge mortality among those discharged alive.
Data Collection Methods: All data were collected at the point of care using encrypted study tablets and these data were then uploaded to a Research Electronic Data Capture (REDCap) database hosted at the BC Children’s Hospital Research Institute (Vancouver, Canada). At admission, trained study nurses systematically collected data on clinical, social and demographic variables. Following discharge, field officers contacted caregivers at 2 and 4 months by phone, and in-person at 6 months, to determine vital status, post-discharge health-seeking, and readmission details. Verbal autopsies were conducted for children who had died following discharge.
Ethics Declaration: This study was approved by the Mbarara University of Science and Technology Research Ethics Committee (No. 15/10-16), the Uganda National Institute of Science and Technology (HS 2207), and the University of British Columbia / Children & Women’s Health Centre of British Columbia Research Ethics Board (H16-02679). This manuscript adheres to the guidelines for STrengthening the Reporting of OBservational studies in Epidemiology (STROBE).NOTE for restricted files: If you are not yet a CoLab member, please complete our membership application survey to gain access to restricted files within 2 business days.
Some files may remain restricted to CoLab members. These files are deemed more sensitive by the file owner and are meant to be shared on a case-by-case basis. Please contact the CoLab coordinator at [email protected] or visit our website
Smart Discharges Uganda Under 5: Phase II clinical data of children 0-6 months
No full textThis data is a subset of the Smart Discharges Uganda Under 5 years parent study and is specific to the Phase II interventional cohort of children aged 0-6 months.
Objective(s): Used as part of the Smart Discharge prediction modelling for adverse outcomes such as post-discharge death and readmission.
Data Description: All data were collected at the point of care using encrypted study tablets and these data were then uploaded to a Research Electronic Data Capture (REDCap) database hosted at the BC Children’s Hospital Research Institute (Vancouver, Canada). At admission, trained study nurses systematically collected data on clinical, social and demographic variables. Following discharge, field officers contacted caregivers at 2 and 4 months by phone, and in-person at 6 months, to determine vital status, post-discharge health-seeking, and readmission details. Verbal autopsies were conducted for children who had died following discharge. .
Data Processing: Created z-scores for anthropometry variables using height and weight according to WHO cutoff. Distance to hospital was calculated using latitude and longitude. Extra symptom and diagnosis categories were created based on text field in these two variables. BCS score was created by summing all individual components.
Limitations: There are missing dates and the admission, discharge, and readmission dates are not in order.
Ethics Declaration: This study was approved by the Mbarara University of Science and Technology Research Ethics Committee (No. 15/10-16), the Uganda National Institute of Science and Technology (HS 2207), and the University of British Columbia / Children & Women’s Health Centre of British Columbia Research Ethics Board (H16-02679). This manuscript adheres to the guidelines for STrengthening the Reporting of OBservational studies in Epidemiology (STROBE).NOTE for restricted files: If you are not yet a CoLab member, please complete our membership application survey to gain access to restricted files within 2 business days.
Some files may remain restricted to CoLab members. These files are deemed more sensitive by the file owner and are meant to be shared on a case-by-case basis. Please contact the CoLab coordinator at [email protected] or visit our website
Smart Discharges Uganda Under 5: Phase I clinical data of children 0-6 months - Covid-19 cohort
No full textThis data is a subset of the Smart Discharges Uganda Under 5 years parent study and is specific to the Phase I observation cohort of children aged 0-6 months collected during the Covid-19 pandemic in 2020.
Objective(s): Used as part of the Smart Discharge prediction modelling for adverse outcomes such as post-discharge death and readmission.
Data Description: All data were collected at the point of care using encrypted study tablets and these data were then uploaded to a Research Electronic Data Capture (REDCap) database hosted at the BC Children’s Hospital Research Institute (Vancouver, Canada). At admission, trained study nurses systematically collected data on clinical, social and demographic variables. Following discharge, field officers contacted caregivers at 2 and 4 months by phone, and in-person at 6 months, to determine vital status, post-discharge health-seeking, and readmission details. Verbal autopsies were conducted for children who had died following discharge. .
Data Processing: Created z-scores for anthropometry variables using height and weight according to WHO cutoff. Distance to hospital was calculated using latitude and longitude. Extra symptom and diagnosis categories were created based on text field in these two variables. BCS score was created by summing all individual components.
Limitations: There are missing dates and the admission, discharge, and readmission dates are not in order.
Ethics Declaration: This study was approved by the Mbarara University of Science and Technology Research Ethics Committee (No. 15/10-16), the Uganda National Institute of Science and Technology (HS 2207), and the University of British Columbia / Children & Women’s Health Centre of British Columbia Research Ethics Board (H16-02679). This manuscript adheres to the guidelines for STrengthening the Reporting of OBservational studies in Epidemiology (STROBE).NOTE for restricted files: If you are not yet a CoLab member, please complete our membership application survey to gain access to restricted files within 2 business days.
Some files may remain restricted to CoLab members. These files are deemed more sensitive by the file owner and are meant to be shared on a case-by-case basis. Please contact the CoLab coordinator at [email protected] or visit our website
Smart Discharges to improve post-discharge health outcomes in children: A prospective before-after study with staggered implementation
No full textDataset Description: This dataset contains materials from a parent study within the Smart Discharges program of research. Materials include the parent study protocol and associated documents. See the Metadata section below for links to related publications and datasets.
Background: Substantial mortality occurs after hospital discharge in children under 5 years old with suspected sepsis. A better understanding of risk and ability to mitigate risk for those who are most vulnerable is needed to reduce child mortality in resource limited settings.
Methods: This is a prospective before-after study with staggered implementation at six Ugandan hospitals. Phase I is a prospective observational cohort study, while Phase II is a stepped-wedge intervention. The study also includes a long-term follow-up phase.
The ultimate outcome to be studied is post-discharge mortality for children < 5 years old by 6 months after admission.
The study has two objectives, each corresponding to a phase:
Phase I: To refine and externally validate the existing post-discharge mortality prediction model.
Phase II: To determine the effectiveness of a Smart Discharge program on post-discharge health seeking behaviour and mortality.
We also seek to lay the groundwork to study the long-term effects of sepsis on morbidity over a 10 year period.
Data Collection Methods: All data were collected at the point of care using encrypted study tablets. These data were then uploaded to a Research Electronic Data Capture (REDCap) database hosted at the BC Children’s Hospital Research Institute (Vancouver, Canada).
At admission, trained study nurses systematically collected data on clinical, social and demographic variables. Following discharge, field officers contacted caregivers at 2 and 4 months by phone, and in-person at 6 months, to determine vital status, post-discharge health-seeking, and readmission details. Verbal autopsies were conducted for children who had died following discharge.
Ethics Declaration: This study was approved by the Mbarara University of Science and Technology Research Ethics Committee (No. 15/10-16; No. 07/01-21), the Uganda National Institute of Science and Technology (HS 2207), and the University of British Columbia / Children & Women’s Health Centre of British Columbia Research Ethics Board (H16-02679).
Associated datasets:
Post-discharge mortality among children under 5 years admitted with suspected sepsis in Uganda: a prospective multi-site study NOTE for restricted files: If you are not yet a CoLab member, please complete our membership application survey to gain access to restricted files within 2 business days.
Some files may remain restricted to CoLab members. These files are deemed more sensitive by the file owner and are meant to be shared on a case-by-case basis. Please contact the CoLab coordinator on this page under "collaborate with the pediatric sepsis colab.
Human papillomavirus prevalence and risk factors among HIV-negative and HIV-positive women residing in rural Eastern Cape, South Africa
No full textObjectives: To investigate the prevalence of high-risk (HR) human papillomavirus (HPV) and factors associated with HR-HPV infection among women from rural Eastern Cape, South Africa. Methods: HPV prevalence was determined by Hybrid Capture 2 assay in cervical specimens from 417 women aged >= 30 years (median 46 years) recruited from the community health clinic in the Eastern Cape. Results: HR-HPV prevalence was 28.5% (119/417), and HIV-positive women had significantly higher HR-HPV prevalence than HIV-negative women (40.6%, 63/155 vs 21.4%, 56/262, respectively; p = 0.001). HIV-positive status (odds ratio (OR) 2.52, 95% confidence interval (CI) 1.63-3.90), having >= 3 lifetime sexual partners (OR 2.12, 95% CI 1.16-3.89), having >= 1 sexual partner in the last month (OR 1.89, 95% CI 1.21-2.92), >= 4 times frequency of vaginal sex in the past 1 month (OR 2.40, 95% CI 1.32-4.35), and having a vaginal discharge currently/in the previous week (OR 2.13, 95% CI 1.18-3.85) increased the risk of HR-HPV infection. In the multivariate analysis, HIV positivity remained strongly associated with HR-HPV infection (OR 1.94, 95% CI 1.17-3.22). Conclusions: Risk factors related to sexual behaviors play a significant role in HR-HPV infection in this population. This report will inform health policymakers on HPV prevalence and contribute to discussions on the use of HPV testing as the primary cervical cancer screening test in South Africa. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases
Exposure to pollutants for household cooking and lighting and pediatric post-discharge mortality following a severe infection in Uganda
No full textBackground: Particulate matter from household air pollution (HAP) is linked to half of all lower respiratory infection deaths among children under 5 years of age. In rural Uganda, similar number of children die 6-months post discharge as during hospitalization for severe infections. However, it is unclear whether exposure to HAP contributes to poor health and death after discharge. We investigated the association between cooking and household lighting practices and mortality 6-months post-discharge among children under 5 years of age treated for severe infection in rural Uganda.
Methods: We conducted a secondary analysis of data from observational cohort studies, conducted between July 2017 to July 2021, among 6,955 children 0 to 5 years admitted to one of six Ugandan hospitals for a severe infectious illness. Clinical signs and symptoms, sociodemographic variables, and mortality up to 6-months post-discharge was collected for all participants, and follow-up rates were >95%. Exposure variables included type of cooking fuel used, location of cooking (e.g. indoors, outdoors), and primary source of household lighting. We assessed post-discharge mortality using simple and multivariate Poisson regression.
Results: The unadjusted risk ratio of 6-month post-discharge mortality by dual or single exposure to pollutant fuel sources for cooking indoors and household lighting, when compared to minimal exposure, was 1.57 (95%CI 1.17, 2.11) and 1.20 (95%CI 0.94, 1.54), respectively. Adjusting for age, sex, distance to hospital, maternal education, and maternal HIV status, the adjusted risk ratios for dual and single exposure became 1.30 (95%CI 0.96, 1.76] and 1.08 (95%CI 0.84, 1.38). There was no significant interaction between exposure and age, sex, maternal education, or anemia status.
Results: This analysis did not find a statistically significant association between HAP and 6-month post-discharge mortality. However, HAP cannot be ruled out as a contributor in this population where malnutrition, comorbidities and sociodemographic vulnerabilities are common.
Data Collection Methods: All data were collected at the point of care using encrypted study tablets and these data were then uploaded to a Research Electronic Data Capture (REDCap) database hosted at the BC Children’s Hospital Research Institute (Vancouver, Canada).
At admission, trained study nurses systematically collected data on clinical, social and demographic variables. Following discharge, field officers contacted caregivers at 2 and 4 months by phone, and in-person at 6 months, to determine vital status, post-discharge health-seeking, and readmission details. Verbal autopsies were conducted for children who had died following discharge.
Data Processing Methods: A proxy exposure variable was created to classify whether each participant was exposed to a pollutant fuel source. This was stratified into three exposure levels.
Ethics Declaration: These studies were approved by the Mbarara University of Science and Technology Research Ethics Committee (15/10–16, 27-Jan-2017), and the University of British Columbia–Children and Women’s Health Centre of British Columbia Research Ethics Board (H16–02679, 09-May-2017).
Study Protocol & Supplementary Materials:
Smart Discharges to improve post-discharge health outcomes in children: A prospective before-after study with staggered implementation NOTE for restricted files: If you are not yet a CoLab member, please complete our membership application survey to gain access to restricted files within 2 business days.
Some files may remain restricted to CoLab members. These files are deemed more sensitive by the file owner and are meant to be shared on a case-by-case basis. Please contact the CoLab coordinator at [email protected] or visit our website
Smart Discharges Uganda Under 5: Phase I clinical data of children 0-6 months
No full textThis data is a subset of the Smart Discharges Uganda Under 5 years parent study and is specific to the Phase I observational cohort of children aged 0-6 months.
Objective(s): Used as part of the Smart Discharge prediction modelling for adverse outcomes such as post-discharge death and readmission.
Data Description: All data were collected at the point of care using encrypted study tablets and these data were then uploaded to a Research Electronic Data Capture (REDCap) database hosted at the BC Children’s Hospital Research Institute (Vancouver, Canada). At admission, trained study nurses systematically collected data on clinical, social and demographic variables. Following discharge, field officers contacted caregivers at 2 and 4 months by phone, and in-person at 6 months, to determine vital status, post-discharge health-seeking, and readmission details. Verbal autopsies were conducted for children who had died following discharge. .
Data Processing: Created z-scores for anthropometry variables using height and weight according to WHO cutoff. Distance to hospital was calculated using latitude and longitude. Extra symptom and diagnosis categories were created based on text field in these two variables. BCS score was created by summing all individual components.
Limitations: There are missing dates and the admission, discharge, and readmission dates are not in order.
Ethics Declaration: This study was approved by the Mbarara University of Science and Technology Research Ethics Committee (No. 15/10-16), the Uganda National Institute of Science and Technology (HS 2207), and the University of British Columbia / Children & Women’s Health Centre of British Columbia Research Ethics Board (H16-02679). This manuscript adheres to the guidelines for STrengthening the Reporting of OBservational studies in Epidemiology (STROBE).NOTE for restricted files: If you are not yet a CoLab member, please complete our membership application survey to gain access to restricted files within 2 business days.
Some files may remain restricted to CoLab members. These files are deemed more sensitive by the file owner and are meant to be shared on a case-by-case basis. Please contact the CoLab coordinator on this page under "collaborate with the pediatric sepsis colab.
