305,358 research outputs found

    The daily diary and the questionnaire are not equivalent for the evaluation of bowel habits

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    COLLABORATOR ITALIAN CONSTIPATION STUDY GROUP: Bellini M, Biagi S, Costa F, De Bortoli N, Gambaccini D, Mammini C, Mumolo MG, Ricchiuti A, Marchi S, Bove A, Balzano A, Sormani MP, Bruzzi P, Battaglia E, Niola P, Verna C, Grassini M, Bocchini R, Cimatti M, Fornasari L, Montaletti I, Pazzi P, Alduini P, Berni I, Ceccarelli G, Bassotti G, Corazzi N, Morozzi B, Viegas LB, Pucciani F, Giani I, Ringressi N

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Hydration-induced dynamical changes in lyophilised and weakly hydrated apoferritin: insights from molecular dynamics simulation

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    The dynamics and functionality of proteins are significantly influenced by their interaction with water. For lyophilised (i.e. h ≤ 0.05 where h = g of H2O/g of protein) and weakly hydrated systems (i.e. h ≤ 0.38) hydration generally enhances protein mobility above the so-called ’dynamical transition’ temperature (Td > 220 K). However, a water-induced mobility hindrance at low temperatures (T<175 K), has been reported in various proteins of varying secondary structure; namely Green Fluorescent Protein (GFP), pig liver esterase, lysozyme, Ribonuclease A (RNAse A) and apoferritin. By focussing on the dynamical behaviour of the apoferritin molecule, this study proposes mechanisms driving these hydration-induced mobility changes, particularly the less understood hindrance at low temperatures. Using atomistic Molecular Dynamics (MD) simulations of horse spleen apoferritin in the lyophilised (h=0.05) and weakly hydrated (h=0.31) states, we report here the impact of water on protein dynamics as a function of temperature. Through residue-specific mean squared displacement (MSD), radial distribution function (RDF), solvent accessible surface area (SASA), local hydration degree and hydrogen bonding analyses, we demonstrate that while water proximity directly correlates with mobility enhancement at high temperatures, the hydration-induced mobility reduction observed at temperatures below 175 K is primarily propagated through the protein backbone

    Una poetica della vita

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    Sintetica ricostruzione delle ragioni e degli sviluppi della Scuola Romana nelle arti, dal primo decennio del XX° secolo agli anni '50

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Author, publisher and bookseller : a tripartite synergy in Nigerian book industry

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    This work is about the roles of Author, Publisher and Bookseller in Book development in Nigeria. The paper started by delving into the history of Book Publishing in Nigeria after which it proceeded by defining who an author, a publisher, and a bookseller is and expatiated on the indispensable roles of these key actors in Nigerian Book Industry and in the emerging Information Society. Furthermore, the various constraints to book development were identified while the paper advised on how the Book Industry can be further promoted in Nigeria. However, the paper concluded and made recommendations on how the Book sector can help in enhancing scholarship in the country
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