1,721,032 research outputs found
Caratterizzazione delle cellule che esprimono GAT-1, il principale trasportatore del gaba, nella sostanza bianca sottocorticale del ratto
No full textCARATTERIZZAZIONE DELLE CELLULE CHE ESPRIMONO GAT-1, IL PRINCIPALE TRASPORTATORE DEL GABA, NELLA SOSTANZA BIANCA SOTTOCORTICALE DEL RATTO.
Bassi S, Fattorini G, Melone M, Conti F
1Dipartimento di Medicina Sperimentale e Clinica, Sezione di Neuroscienze e Biologia Cellulare; 2 Foundazione per la Medicina Molecolare, Università Politecnica delle Marche, Ancona
L’inibizione mediata dal GABA esercita un potente controllo sull’attività neuronale. I trasportatori del GABA, soprattutto GAT-1, che è il più importante, contribuiscono a modulare l'azione di questo neurotrasmettitore. L’alterazione dell’attività o dell’espressione dei trasportatori può avere un ruolo determinante nella fisiopatologia di alcune malattie. Sebbene gli elementi GAT-1 + nella sostanza bianca sottocorticale siano già stati descritti, non sono mai state studiate la distribuzione e la natura delle cellule che esprimono GAT-1. Abbiamo quindi studiato sistematicamente la distribuzione, il numero e la natura delle cellule GAT-1+ nella sostanza bianca sottocorticale attraverso microscopia ottica, elettronica e confocale.
L’analisi al microscopio ottico della sostanza bianca sottocorticale ha rivelato la presenza di numerose cellule GAT-1 +. Queste hanno mostrato diverse caratteristiche morfologiche: alcune assomigliavano a neuroni, altre ricordavano cellule gliali. La microscopia elettronica pre-embedding ha mostrato l’immunoreattività di GAT-1 in neuroni, astrociti, oligodendrociti (maturi e immaturi) e microglia. Per quantificare GAT-1 nei diversi tipi cellulari, abbiamo studiato una serie di doppie marcature all’immunofluorescenza per le quali sono stati utilizzati GAT-1/NeuN; GAT-1/GFAP; GAT-1/NG2; GAT-1/RIP e GAT-1/CD11b. I risultati hanno mostrato che il 30,65% di cellule GAT-1 + nella sostanza bianca sottocorticale esprime NeuN; il 32,22% esprime GFAP; il 11,75% esprime NG2; il 14,78% esprime RIP e il 20,48% esprime CD11b.
Considerando che tutti i tipi di cellule presenti nella sostanza bianca sottocorticale esprimono GAT-1, questa osservazione indica che la ri-captazione di GABA operata da GAT-1 potrebbe non limitarsi semplicemente alla regolazione dei livelli sinaptici di GABA
Un «giardiniere e botanico delle lingue»: Andrea Zanzotto traduttore e autotraduttore
Full text linkThis work aims to investigate Andrea Zanzotto's literary production from the point of view of translation. First of all, his activity of transcription in Italian of his own poems is examined, since he sometimes composes in dialect instead of the official language – which is his main means of expression – or, in the case of pseudo-haikus, in English. The analysis then focuses on translations into Italian from works by other authors, written both in prose and poetry, mainly in French. Zanzotto realized them either on commission for publishing or as a private exercise, then occasionally printed. This dissertation describes the linguistic and stylistic issues the translator dealt with in each different case, also taking into account his parallel original production in verse and prose, and his reflections as a critical essayist.Il presente lavoro si propone di indagare l'opera letteraria di Andrea Zanzotto dal punto di vista della traduzione. Si esamina dunque da un lato l'attività di trascrizione in lingua italiana che il poeta ha esercitato sui propri versi quando composti originariamente in dialetto – idioma impiegato in diverse sue raccolte poetiche, anche se in misura minore rispetto alla lingua ufficiale – o, nel caso degli pseudo-haiku, in inglese. L'analisi si concentra successivamente sul lavoro di traduzione da altri autori, sia in prosa sia in poesia, in prevalenza di area francese, svolto da Zanzotto in vista di edizioni commissionate o in qualità di esercizio privato poi oggetto di pubblicazione. Sono delineate così le questioni linguistiche e stilistiche di volta in volta affrontate dal traduttore, tenendo conto, parallelamente, della sua produzione originale in versi e in prosa nonché delle sue riflessioni di saggista critico
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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