1,720,990 research outputs found
Bassi (Domenico). Saggio di Bibliografia mitologica. Puntata I : Apollo
No full textReinach Salomon. Bassi (Domenico). Saggio di Bibliografia mitologica. Puntata I : Apollo. In: Revue des Études Grecques, tome 9, fascicule 34,1896. pp. 313-314
Resezione epatica maggiore con modulazione del flusso portale nel ratto: studio emodinamico e ruolo della Serpina B3 sul danno cellulare
Full text linkBackground: The increased blood flow per gram of liver immediately after liver resection results in an increase intrahepatic shear stress that seems to be involved in the stimulation and regulation of regeneration. A portal hyperflow however causes a serious liver damage due to high intraparenchymal shear stress. This phenomenon has been studied mainly in living donor liver transplantation or cadaveric split liver and in extreme liver resections. The result is a syndrome defined Small for Size which has many similarities with liver failure after hepatectomy and it is associated with severe morbidity and mortality. Among the mechanisms of cell protection and regeneration after liver resection, the Serpin B3 (serine protease inhibitor with anti-apoptotic action) could have a role in the control of apoptosis. The portal flow modulation through the use of port-caval shunt, embolization of the splenic artery, splenectomy has been proposed to prevent the damage due to a high shear stress.
Aim of the study: The aim of the study is the analysis of hemodynamic changes assessed by ultrasound of the portal and hepatic artery circulation in rats after major liver resection and liver resection associated with splenectomy and their impact on the parenchymal damage. The study also aims to assess the relationship between the Serpin B3 expression and cell damage after resection in different groups of animals.
Material and Methods: 23 male Wistar rats were divided into 4 groups: Group A (5 animals) underwent a 30% liver resection, Group B (8) 60% resection, the Group C (7) 60% resection associated with splenectomy and Group D (3) constituted the control group and underwent a simple laparotomy (sham operated). Immediately before surgery (T0) and after two hours (T1) blood samples were drawn from each rat (dosage of AST, ALT, LDH, lactic acid and ammonium). Samples of liver tissue were collected after the resection and 2 hours after surgery. An hepato-splenic echo-color Doppler was done at T0 and T1 in all the rats. On bioptic samples of the various groups, in addition to standard histopathological analysis, the extraction and quantification of RNA Serpin B3 was performed. On the same biopsies the apoptotic index quantification was tested with TUNEL.
Results: The eco-Doppler study showed a portal flow per gram of liver in group B greater than the other 3 groups. Only in group B the hepatic arterial resistance had increased significantly; also the resistance of the splenic artery appeared increased. In group C, there was a tendency to reduction in portal flow and also the hepatic arterial
resistance tended to decrease in this same group. The expression of Serpin B3 in group B increased more than the other groups. The TUNEL test showed a greater degree of apoptosis in group C than in group B and in the control. Conclusions: The post-resection liver damage is already present 2 hours after hepatectomy and it is probably due to the hemodynamic changes that this causes.
The role of Serpina B3 has not been yet clarified in the protection of the damage after major liver resection; what we have seen in our study is that to a greater expression of Serpin B3 is associated a lower apoptosis
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Ileal neuroendocrine carcinoma following restorative proctocolectomy for colonic adenocarcinoma in Crohn's disease.
No full textQ2 autore intermedio Punti
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