86,661 research outputs found

    Conservation of Earthen Architecture: an overview of International Guidelines and Resolutions

    No full text
    Attention first turned to the conservation of the world’s earthen heritage towards the end of the 1960s, following a few archaeological campaigns in the Middle East (Iraq). Starting in 1972, the topic became the subject of special academic conferences spearheaded by Piero Gazzola, the first president of ICOMOS. Today, a fresh reading of the Proceedings and Resolutions resulting from the international meetings over a fifty-year period allows us to ‘take stock’ of the current situation and, in particular, compare the theoretical premises with the actual work that has been done. Through these documents and the rich body of published research that they inspired, a considerable corpus of in-depth (increasingly geographically broad) information about earthen heritage emerges to which the development of theoretical reflections on the topic and coherent conservation practices do not always correspond. Since historical earthen architecture constitutes a considerable part of the Cultural Heritage identified by UNESCO (around 15% of the World Heritage List)1, conservation of this evidence cannot neglect the essential aspects for which it is recognised as “Heritage of Humanity”2. While recognising that the material out of which these works are made poses particularly complex conservation problems due to its perishable nature, this characteristic cannot justify total reconstruction or replacement activity that would jeopardise its authenticity and erase its history. Such practices are extraneous to the conservation of historical-cultural heritage. In the following, we shall trace the conceptual path marked out by the conferences over the years, with the aim of determining its topicality and identifying the criticalities entailed by the various developments, more or less in line with the original conservation premises

    The role of the vgf gene and VGF-derived peptides in nutrition and metabolism

    No full text
    Energy homeostasis is a complex physiological function coordinated at multiple levels. The issue of genetic regulation of nutrition and metabolism is attracting increasing interest and new energy homeostasis-regulatory genes are continuously identified. Among these genes, vgf is gaining increasing interest following two observations: (1) VGF-/- mice have a lean and hypermetabolic phenotype; (2) the first VGF-derived peptide involved in energy homeostasis, named TLQP-21, has been identified. The aim of this review will be to discuss the role of the vgf gene and VGF derived peptides in metabolic and nutritional functions. In particular we will: (1) provide a brief overview on the central systems regulating energy homeostasis and nutrition particularly focusing on the melanocortin system; (2) introduce the structure and molecular characteristic of vgf; (3) describe the phenotype of VGF deficient mice; (4) present recent data on the metabolic role of VGF-derived peptides, particularly focusing on one peptide named TLQP-21
    corecore