1,721,087 research outputs found
Beta-Adrenergic Receptors-Activation Is Required for the Pro-Lipolytic and Anti-Obesity Effect of the Vgf-Derived Peptide Tlqp-21
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Scarce and unpredictable, yet obesogenic: modeling the impact of food insecurity on adiposity in mice
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From Psychosocial Stress to Herpes Simplex Infection: Sequentially Coordinated Events Regulated in a Cascade Fashion
No full textGene x Environment mouse models for mood disorders.
No full textMuch of the impact of genes on mood disorders likely depends on interactions between genes and the environment. Recent studies demonstrating an
interaction between specific genes and life stressful events (early and/or adult) in the modulation of several mood disorders (e.g., serotonin transporter and brain-derived neurotrophic factor genes) have compelled researchers to incorporate information about adverse environmental experiences into the study of genetic risk factors; these same gene-by-environment (G×E) interactions have been identified in mouse models. Notably, G×E not yet
described in humans (e.g., serotonin 1A receptor gene) have been uncovered, providing helpful indications to discover similar interactions in humans.
Accurate knowledge of the modality of expression of gene-by-stress interaction may help design prevention protocols aimed at identifying susceptibility to mood disorders on the basis of genetic predisposition and exposure to environmental stressful conditions, thus providing patients with appropriate pharmacological and psychological support
Effects of the housing social context on emotional behaviour and physiological correlates in female mice
No full textIn laboratory breeding procedures, mice are usually housed in single-sex unfamiliar groups since weaning, while individual housing is widely employed in many experimental settings. While there is a considerable amount of evidence on the behavioural and physiological effects of various social contexts in male mice
and rats, few data are available on female mice. We examined short-term modulation of social context in the housing environment on exploratory and emotional behaviours in response to novelty (i.e., free-exploratory open field) and on physiology (i.e. organs and body weight, and basal corticosterone level) of female CD1 mice, taking into account the estrous phase as an additional variable. Living alone or grouped with siblings
or with unfamiliar females for a short period (7 days) did not affect any physiological indexes of stress in female house mice and had marginal effects on emotional behaviour. When challenged with a free choice between a novel environment and their home cage, female mice housed with siblings did not differ on any behavioural parameter from females housed with same-aged unfamiliar mice, while individually housed
females showed higher propensity to enter the novel arena but no differences in activity or in anxiety as compared to grouped mice. Information about sex specifics under standard housing conditions as well as in response to common laboratory procedures could be important for the understanding of sex differences in vulnerability to psychiatric disorders and response to drug treatment
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