1,720,954 research outputs found
L'inibizione delle metalloproteasi quale possibile nuovo approccio per il trattamento delle malattie reumatiche
No full textObjective. Osteoarthritis (OA) and Rheumatoid Arthritis (RA), however different in pathophysiology, share the degradative process. In the aim to develop new drugs with selective inhibiting action towards the enzymes responsible for the extracellular matrix damage, scientific research is focused on two main branches: 1) development of new drugs with specific inhibiting action towards MMPs; 2) study of the pharmacologic profile of drugs, currently used during therapy of rheumatic diseases, in order to identify a possible inhibiting action towards the degradative enzymes. Methods. The interaction between Indomethacin or Meloxicam and collagenase activity from human synovial fluids was studied by using a fluorogenic substrate. Results. In experimental conditions Indomethacin did not show any activity against collagenase activity, when used at the therapeutical plasmatic or synovial fluid concentrations. On the other hand, Meloxicam caused a 53% reduction of collagenase activity. Conclusions. According to our studies, NSAIDs could downregulate the activity of enzymes responsible for the degradation of the extracellular matrix
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Rifamycins as inhibitors of collagenase activity: Their possible pharmacological role in collagen degradative diseases
No full textThe interaction of commercial rifamycin SV, rifamycin B, rifampicin and some other semi-synthetic analogous with collagenase in vitro was studied by using the fluorogenic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2. Increased fluorescence, due to the removal of the NH2-terminal dinitrophenyl group, after cleavage of the probe by collagenase was monitored and related to the enzyme activity. The peptide was an efficient substrate for collagenase with a K(m) of 0.83 μM at 20°C in the presence of 10 μM Ca2+, pH = 7.5. In the same conditions, in the presence of rifamycin SV, rifampicin and rifamycin B or their semi-synthetic analogues AM41, MC11 and MC30, a marked inhibition of the enzyme activity was observed and an IC50 ranging from 13.1 to 20.7 μM was calculated. The inhibitory effect was reversible as demonstrated by restoration of enzyme activity by dialysis. These results may support the hypothesis that drugs based upon inhibitors of collagenase activity will provide a therapeutical tool for the underlying pathological destruction of extracellular matrix observed for instance in rheumatoid arthritis as reported by several authors
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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