6,089 research outputs found

    Bain, SC

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    SC author and illustrator Kate Salley Palmer signing book

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    Photograph of SC author and illustrator Kate Salley Palmer signing boo

    Kerr, George Bain, 1874-1965 (SC 922)

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    Finding aid and scan (Click on Additional Files below) for Manuscripts Small Collection 922. Carbon copy of letter, 20 April 1961, written by Ruth Thurston, Bowling Green, Kentucky, nominating George Bain Kerr for Kentucky Selective Service Father of the Year. Kerr was chairman of the local board and Thurston was clerk. Also, copy of Kerr’s 1965 obituary

    Book signing by SC author and illustrator Kate Salley Palmer

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    Photograph of Book signing by SC author and illustrator Kate Salley Palme

    Investigation of linkage of chromosome 8 to type 1 diabetes - Multipoint analysis and exclusion mapping of human chromosome 8 in 593 affected sib-pair families from the UK and US

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    Type 1 diabetes is a common multifactorial disease that is strongly clustered in families: the sibling risk-to-population prevalence ratio (lambda(s)) is 15 (6%/0.4%) (1). Two loci, IDDM1 in the major histocompatibility complex (MHC) on chromosome 6p21 and IDDM2 in the insulin gene (INS) region of chromosome 11p15.5 can account for similar to 50% of the observed familial clustering (1). Locus-specific lambda(s) values (1) in 356 U.K. affected sib-pair families (2) for IDDM1 and IDDM2 are 3.0 and 1.3, respectively, or 41 and 8%, assuming a multiplicative model (J.A.T., unpublished observations). The rapid reduction in risk from first- to second- to third-degree relatives of type 1 diabetic patients (3) and whole genome scanning of a spontaneous mouse model of autoimmune type 1 diabetes (4,5) suggest that other genes may account for the rest of the familial clustering (1,4,5). In humans, two genome-wide scans, both based on the analysis of affected sib pairs, have been published so far (6,7), with the larger scan evaluating 290 markers in 96 U.K. families (data were analyzed in 93 of these families, so henceforth, this scan will be referred to as the 93 U.K. family scan) (6). The main conclusions of these studies were that the presence elsewhere in the genome of a second gene with an effect similar to IDDM1 (lambda(s) = 3) is unlikely, and that other genes with lambda(s) < 3 are involved. Subsequently, additional evidence for linkage to some of these and other regions has been reported (8-10)

    High-resolution clean-sc

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    In this paper a high-resolution extension of CLEAN-SC is proposed: HR-CLEAN-SC. Where CLEAN-SC uses peak sources in “dirty maps” to define so-called source components, HR-CLEAN-SC takes advantage of the fact that source components can likewise be derived from points at some distance from the peak, as long as these “source markers” are on the main lobe of the Point Spread Function (PSF). This is very useful when sources are closely spaced together, such that their PSFs interfere. Then, alternative markers can be sought in which the relative influence by PSFs of other source positions is minimised. For those markers the source components better agree with the actual sources, which allows for better estimation of their locations and strengths. This paper outlines the theory needed to understand this approach and discusses applications to 2D and 3D microphone array simulations with closely spaced sources

    SC author and illustrator Kate Salley Palmer talking to event attendees

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    Photograph of SC author and illustrator Kate Salley Palmer talking to Rita Lewi

    Ca-modified Al–Mg–Sc alloy with high strength at elevated temperatures due to a hierarchical microstructure

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    Al-Mg alloys are normally prone to lose part of their yield and tensile strength at high temperatures due to insufficient thermal stability of the microstructure. Here, we present a Ca-modified Al–Mg–Sc alloy demonstrating high strength at elevated temperatures. The microstructure contains Al4Ca phases distributed as a network along the grain boundary and Al3(Sc,Zr) nano-particles dispersed within the grains. The microstructure evolution and age-hardening analysis indicate that the combination of an Al4Ca network and Sc-rich nano-particles leads to excellent thermal stability even upon aging at 300 °C. The tensile strength of the alloy for temperatures up to 250 °C is significantly improved by an aging treatment and is comparable with the commercial heat-resistant aluminum alloys, i.e., A356 and A319. At a high temperature of 300 °C, the tensile strength is superior to the above-mentioned commercial alloys, even more so when expressed as the specific strength due to the low density of Ca-modified Al–Mg–Sc alloy. The excellent high-temperature strength results from a synergistic effect of solid solution strengthening, grain boundary strengthening and nanoparticle order strengthening.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Novel Aerospace Material

    SC-Square: Overview to 2021.

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    This extended abstract was written to accompany an invited talk at the 2021 SC-Square Workshop, where the author was asked to give an overview of SC-Square progress to date. The author first reminds the reader of the definition of SC-Square, then briefly outlines some of the history, before picking out some (personal) scientific highlights

    SC-Square: Overview to 2021.

    No full text
    This extended abstract was written to accompany an invited talk at the 2021 SC-Square Workshop, where the author was asked to give an overview of SC-Square progress to date. The author first reminds the reader of the definition of SC-Square, then briefly outlines some of the history, before picking out some (personal) scientific highlights
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