838 research outputs found
Scoping review protocol: Intensive short term dynamic psychotherapy for anxiety and related disorders
No full textCorresponding author:
Nathan C. Thoma (see protocol file for contact information
Investigation of the neuroprotective effects of Haskap berry (Lonicera caerulea) extract on Caenorhabditis elegans
No full textAlzheimer’s Disease (AD) is the most common form of neurodegenerative dementia in Canada. Many researchers are investigating therapeutic options for the prevention and treatments of AD using natural plant-based sources i.e. superfoods.Haskap berries (HBs) (Fig. 1) are originally native to Siberia and northeastern Asia but have recently expanded to the Canadian market.The compounds found in HBs, such as the anthocyanin cyanidin-3-glucoside (C3G), have demonstrated in purified in vitro studies to have beneficial effects on lifespan, development, and neuronal growth. Research goals of this project are to continue previous work into the investigation of the effects of Haskap Berry Extract (HBE) on C. elegans and determine if HBE has neuroprotective effects in C. elegans, in terms of delaying the onset of phenotypic symptoms, and reducing the accumulation of Aβ plaques.This poster won an Associate Vice-President, Research, Engagement, and Graduate Studies award (2020). Advisor: Dr. Nathan Bialas, Department of Biology
The effects of Haskap Berry (Lonicera caerulea) extract on oxidative stress resistance: and its intergenerational inheritance in Caenorhabditis elegans
No full textAs superfoods gain popularity in mainstream media, investigating their potential health benefits has become an attractive area of research. Fruits such as açai berries, blueberries and strawberries contain high levels of antioxidants that have been shown to reduce the risk of diabetes, cardiovascular disease, and cognitive decline. In this study, we examined the benefits of the lesser-known haskap berry (Lonicera caerulea) on the model organism Caenorhabditis elegans. In previous years it was determined that haskap berry extract can increase lifespan and stress resistance in C. elegans via the daf-16 pathway (homologous to the FOXO pathway in mammals). In this study, the intergenerational transmission of these benefits was explored as were the downstream proteins that are affected by DAF-16. It was found that the lifespan extension benefits gained from HBE do exhibit intergenerational transmission in C. elegans. Using transgenic strains of C. elegans it was found that HBE upregulates the expression of SOD-3 and protects worms from oxidative stress. These results highlight some of the benefits of haskap berry and suggest it is a prime candidate for further study.This poster won the Dean, Faculty of Science Award (2021)
Advisor: Dr. Nathan Bialas, Department of Biolog
Cwbr Author Interview: God\u27s Almost Chosen Peoples: A Religious History Of The American Civil War
No full textInterview with George C. Rable, Professor and holder of the Summersell Chair in Southern History at the University of Alabama Interviewed by Nathan A. Buman
Civil War Book Review (CWBR): I\u27m here today with George Rable, author of God\u27s Almost Chosen Peoples: A Religious History of the American Civil War. Professor Rable, thank you so much for joining me. George Rable (GR): My pleasure
Big Data, Big Libraries, Big Problems?: the 2014 LibTech Anti-talk?
No full textThe desire to create automatons is a familiar theme in human history, and during the age of the Enlightenment mechanical automatons became not only an “emblem of the cosmos”, but a symbol of man’s confidence that he would unlock nature’s greatest mysteries and fully harness her power. And yet only a century later, automatons had begun to represent human repression and servitude, a theme later picked up by writers of science fiction. Man’s confidence undeterred, the endgame of the modern scientific and technological mindset, or MSTM, seems to be increasingly coming into view with the rise of “information technology” in general and “Big data” in particular. Along with those who wield them, these can be seen as functioning together as a “mechanical muse” of sorts – surprisingly alluring – and, like a physical automaton can serve as a symbol – a microcosm – of what the MSTM sees (at the very least in practice) as the cosmic machine, our “final frontier”. And yet, individuals who unreflectively participate in these things – giving themselves over to them and seeking the powers afforded by the technology apart from technology’s rightful purposes – in fact yield to the same pragmatism and reductionism those wielding them are captive to. Thus, they ultimately nullify themselves philosophically, politically, and economically – their value increasingly being only the data concerning their persons, and its perceived usefulness. Likewise libraries, the time-honored place of, and symbol for, the intellectual flowering of the individual, will, insofar as they spurn the classical liberal arts (with the idea that things are intrinsically good, and in the case of humans, special as well) in favor of the alluring embrace of MSTM-driven “information technology” and Big data - unwittingly contribute to their irrelevance and demise as they find themselves increasingly less needed, valued, wanted. Likewise for the liberal arts as a whole, and in fact history itself, if the acid of a “science” untethered from what is, in fact, good (intrinsically), continues to gain strengt
PIV measurements of a turbulent jet issuing from round sharp-edged plate
No full textThe original publication is available at www.springerlink.comAn experimental investigation is presented of a turbulent jet issuing from a round sharp-edged orifice plate (OP) into effectively unbounded surroundings. Planar measurements of velocity were conducted using Particle Image Velocimetry (PIV) in the near and transition regions. The Reynolds number, based on the jet initial diameter and velocity, is approximately 72,000. The instantaneous and mean velocities, Reynolds normal and shear stresses were obtained. The centerline velocity decay and the halfvelocity radius were derived from the mean velocity. It is revealed that primary coherent structures occur in the near field of the OP jet and that they are typically distributed asymmetrically with respect to the nozzle axis. Comparison of the present PIV and previous hotwire measurements for the OP jet suggests that high initial turbulence intensity leads to reduced rates of decay and spread of the mean flow field and moreover a lower rate of variation of the turbulence intensity. Results also show that self-similarity of the mean flow is well established from the transition region while the turbulent statistics are far from self-similar within the measured range to 16 diameters.J. Mi, P. Kalt, G. J. Nathan and C. Y. Won
Correction: Need for ICU and outcome of critically ill patients with COVID-19 and haematological malignancies: results from the EPICOVIDEHA survey (Infection, (2024), 52, 3, (1125-1141), 10.1007/s15010-023-02169-7)
No full textAcknowledgements Members of the EPICOVIDEHA registry: Joseph Meletiadis, Florian Reizine, Jan Novák, Summiya Nizamuddin, Roberta Di Blasi, Alexandra Serris, Pavel Jindra, Sylvain Lamure, François Danion, Maria Chiara Tisi, Mario Virgilio Papa, Nurettin Erben, ľuboš DrgoňA, Nathan C. Bahr, Murtadha Al-Khabori, Ayten Shirinova, Jörg Schubert, Lisset Lorenzo De La Peña, José-Ángel Hernández-Rivas, Elena Busch, Josip Batinić, Giuseppe Sapienza, Mohammad Reza Salehi, Reham Abdelaziz Khedr, Nina Khanna, Baerbel Hoell-Neugebauer, Ana Groh, Eleni Gavriilaki, Rita Fazzi, Rémy Duléry, Roberta Della Pepa, Mario Delia, Nicola Coppola, Maria Calbacho, Darko Antić, Hossein Zarrinfer, Ayel Yahia, Vivien Wai-Man, Ana Torres-TIenza, Alina Daniela Tanasa, Andrés Soto-Silva, Laura Serrano, Enrico Schalk, Ikhwan Rinaldi, Gaëtan Plantefeve, Monica Piedimonte, Maria Enza Mitra, Carolina Miranda-Castillo, Jorge Loureiro-Amigo, Ira Lacej, Martin Kolditz, María-Josefa Jiménez-Lorenzo, Guillemette Fouquet, Omar-Francisco Coronel-Ayala, Mathias Brehon, Panagiotis Tsirigotis, Anastasia Antoniadou, Gina Varricchio, Maria Vehreschild, Agostino Tafuri, José-María Ribera-Santa Susana, Joyce Marques De Almeida, María Fernández-Galán, Avinash Aujayeb, Athanasios Tragiannidis, Malgorzata Mikulska, Sein Win, Elizabeth De Kort, Hans-Beier Ommen, Donald C. Vinh, Hans Martin Orth, Sandra Malak, Przemyslaw Zdziarski, Modar Saleh, Chi Shan Kho, Fabio Guolo, M. Mansour Ceesay, Christopher H. Heath, Sergey Gerasymchuk, Monica Fung, Maximilian Desole, Erik De Cabo, Tania Cushion, Fazle Rabbi Chowdhury, Louis Yi Ann Chai, Fevzi Altuntaş, Charlotte Flasshove. The original article has been updated
Endemic mycoses – are we making progress in management?
No full textPURPOSE OF REVIEW: The endemic fungi are a significant cause of morbidity and mortality in effected patients. The range of endemicity for these are expanding with infections observed outside of traditional locations. Enhanced diagnostic and treatment practices may significantly alter patient outcomes. RECENT FINDINGS: Recently completed clinical trials have focused on an assessment of improving efficacy while minimizing patient toxicity. Practice changing trials have been completed in histoplasmosis showing the utility of a single up-front liposomal amphotericin B dose followed by standard itraconazole dosing. The recent evaluation of several antifungal options including isauvconazole in the treatment of coccidioidomycosis also show promise for additional therapeutic agents. A recently conducted trial has also shown the superiority of amphotericin B therapy over itraconazole in the treatment of talaromycosis. SUMMARY: The increased range of endemic mycoses coupled with the growing immunocompromised patient population mandates continued investigation of improved diagnostic and therapeutic options. Advances in these areas have led to more rapid diagnosis and more efficacious antifungal therapy
Review: Beating Hearts: Abortion and Animal Rights
No full textThis is a book review of Beating Hearts: Abortion and Animal Rights by Sherry F. Colb and Michael C. Dorf (Columbia University Press, 2016). KEYWORDS: abortion, animal rights, ethics, book review, Applied Ethics, Arts and Humanities, Philosoph
MOO for the conceptual design of structures
No full textThesis: S.M. in Building Technology, Massachusetts Institute of Technology, Department of Architecture, 2016.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 107-113).Using computational tools, fast and accurate predictions of building performance are increasingly possible. In parallel, the expectations of a high-performance building have been rising in contemporary architecture, as designers must synthesize many inputs to arrive at a design that fulfills a wide range of requirements. Despite the clear need for assistance in prioritizing and managing different design objectives, advances in performance analysis have not commonly translated into guidance in early stage design, as the limits of the traditional design process and a separation of disciplines have relegated performance feedback to later phases. In order to facilitate better design on a holistic level, researchers in related areas have developed multiobjective optimization (MOO), which is a methodology intended for navigating complex design spaces while managing and prioritizing multiple objectives. However, after reviewing existing design optimization research and considering current usage of optimization in AEC practice, a number of clear research questions arise: How can conceptual, architectural design problems be formulated and solved using MOO in a way that generates diverse, high-performing solutions? What is the best way for the designers of buildings and structures to interact with MOO problems? Finally, how does the use of MOO in the conceptual phase affect design possibilities and outcomes? This thesis addresses these key research questions, along with a number of secondary questions, through a combination of design case studies, tool development, user experience testing, and historical analysis. First, it presents a conceptual framework for implementing MOO within architectural parametric design tools in flexible, interactive way. Next, it shows the outcomes of a conceptual design exercise in which participants are given increasing access to performance feedback. Finally, through the application of MOO to three long span roof case studies, it demonstrates how MOO can lead to diverse, high-performing results that are difficult to generate through other means, before introducing a new way in which multi-objective techniques can be used to analyze historical structures. Together, these contributions encourage more widespread and effective use of multi-objective optimization in conceptual design, leading to better performing buildings and structures without overly constraining creative, innovative designers. Key words: multi-objective optimization, design space exploration, conceptual design, design tradeoffs, interactive design tools, structural design, embodied and operational energy.by Nathan C. Brown.S.M. in Building Technolog
- …
