1,721,088 research outputs found
Mechanisms mediating somatostatin-induced reduction of cytosolic free calcium in PC12 cells
No full textIn PC12 cells, somatostatin (SRIF) decreases the Ca21 in ̄ux in response to high K1 through the inhibition of voltagedependent
Ca21 channels. In the present study, we measured the intracellular Ca21 concentration ( [Ca21]i) following the
application of SRIF-14 or its analogues which bind to different SRIF subtype (sst) receptors. Their application differentially
reduces [Ca21]i (octreotide . SRIF-14 . CGP23996 . BIM23056) in a dose-dependent manner. Pretreatment with a
SRIF antagonist prevents the SRIF-induced inhibition of [Ca21]i. These results suggest the involvement of speci®c
membrane receptors and are in line with recent ®ndings indicating the presence of receptor mRNAs on PC12 cells.
Our results also exclude the possibility that SRIF interacts with opioid receptors and suggest that the SRIF-induced
inhibition of [Ca21]i is mediated by mechanisms involving PTX-sensitive G-proteins and PK-dependent pathways
Effects of somatostatin on cytosolic Ca2+ levels in PC12 cells: a spectrofluorimetric study
No full text
Expression of somatostatin receptor subtype 2A (SST2A) in the postnatal rabbit retina and its regulation
No full textEnucleation enhances ipsilateral flash evoked responses in the ectostriatum of the zebra finch (Taeniopygia guttata castanotis Gould)
Full text linkEngelage J, Bischof H-J. Enucleation enhances ipsilateral flash evoked responses in the ectostriatum of the zebra finch (Taeniopygia guttata castanotis Gould). Experimental Brain Research. 1988;70(1):79-89.The tectofugal pathway in birds has been reported to process primarily information from the contralateral eye. Although this pathway has access to the contralateral hemisphere by various connections, electrophysiological recordings up to now have failed to demonstrate any excitatory influence of visual stimulation in the higher stations of this pathway. This study is the first to demonstrate an excitatory projection from the ipsilateral eye to the telencephalic projection area of the tectofugal pathway by recordings of visually evoked potentials in the ectostriatum. The excitatory projection probably leads from the eye to the contralateral tectum opticum, then recrosses back to the nucleus rotundus of the ipsilateral side where it reaches the ectostriatum. In normal birds, the ipsilateral stimulus responses in the ectostriatum are smaller in amplitude and have a longer latency than responses to contralateral stimuli. In unilaterally enucleated birds, the ipsilateral response is enhanced in the ectostriatum and can be detected in the nucleus rotundus, too. The results suggest that in normal birds the ipsilateral response is inhibited to a high degree by spontaneous activity of the contralateral eye. Possibly, this counterbalanced inhibition provides a mechanism for weighting information from the left and right eye field in order to ensure adequate processing of stimuli
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Altiero Spinelli e Alcide De Gasperi: due opposte fedi e una stessa idea d'Europa.
No full textUn parallelismo tra Altiero Spinelli e Alciide De Gasperi, due uomini politici di confessione religiosa e di afferenza partitica diverse, ma saldamente uniti dal comune ideale europeista, per la realizzazione del quale collaborarono da veri federalisti
Neural mechanism underlying spontaneous flashing and its modulation in the firefly Luciola lusitanica
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