1,720,973 research outputs found
Studio radioisotopico nella patologia bollosa
No full textNelle patologie bollose polmonari la medicina nucleare è in grado di offrire informazioni riguardanti sia la distribuzione del flusso ematico polmonare, sia la ventilazione alveolare utilizzando uno studio combinato: la scintigrafia ventilo/perfusoria. La PET-TC con 18F-FDG può dare importanti notizie nel caso in cui, durante il follow-up, la patologia bollosa si complica con la comparsa di un'area di addensamento che potrebbe essere indice di presenza di lesione maligna. La PET-TC, grazie alla possibilità di indagare i processi metabolici, è diventata un mezzo essenziale nel differenziare le lesioni maligne da quelle di altra natura
Peripheral Quantitative Computer Tomography (pQCT), Broad Band Ultrasound Attenuation (BUA) and Speed of Sound (SOS) in a population of normal females aged from 8 to 20 years
No full textThe sexual growth influences the position of bone density peak. The results obtained show a statistically significative correlation between BUA and BMD versus age, the menarche-age, and the period of exposure of bone-tissue to the oestrogen. After all, pQCT and ultrasound are useful techniques to evaluate bone density and structure also in a growing population. The results of this study show the possibility to use bidimensional quantitative ultrasound devices in clinical practice also in young population taking in account age and sexual development
99mTc-HMPAO Labelled autologous granulocytes scintigraphy in Crohn’s disease
No full text99mTc-HMPAO labelled granulocytes scintigraphy can accurately assess Crohn's disease extent, its severity and relapses, and providing a non-invasive alternative technique to colonoscopy and radiological investigations
Splenosis: 99mTc-labelled colloids provide the diagnosis in splenectomised patients
No full textThe diagnosis of abdominal splenosis is usually made by surgical biopsy of an abdominal mass incidentally discovered on abdominal ultrasonography, computed tomography or magnetic resonance imaging. To avoid exploratory surgery, 99mTc-sulphur colloid scintigraphy may be used: this technique is the most specific, easily performable, and cost-effective tool for the diagnosis of splenosis
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Functional, structural, and distribution analysis of the chorionic gonadotropin receptor using murine monoclonal antibodies
Full text linkLH and human chorionic gonadotropin (hCG) control steroid production and gametogenesis. They also function as growth factors through interaction with a specific receptor that is a member of the seven-transmembrane receptor family coupled via G proteins to signal pathways involving cAMP and phospholipase C/inositol 3 phosphate. For this study, monoclonal antibodies (mAbs) were raised against the human LH receptor (LHR)/hCG receptor (hCGR), using Chinese hamster ovary LHR-transfected cells as the immunogen. Two reagents were then selected on the basis of their ability to recognize the full-length transmembrane receptor expressed both by Chinese hamster ovary LHR-transfected cells and by a limited number of tumor cell lines. One of these mAbs reacts with the LHR/hCGR in tissue sections of both frozen and paraffin-embedded specimens. This unique feature allowed us to map the cytological distribution of LHR/hCGR in human breast tissues at different stages of development in physiological and benign pathological conditions. The same mAb proved to be agonistic: receptor ligation elicits signals that modulate the growth of selected breast tumor cell lines. This observation suggests that the mAb recognizes an epitope that is included in the domain of the receptor involved in the interaction with the natural ligand
Role of carcinoembryonic antigen, magnetic resonance imaging, and positron emission tomography-computed tomography in the evaluation of patients with suspected local recurrence of colorectal cancer
No full textThe role of carcinoembryonic antigen (CEA), magnetic resonance imaging (MRI), and positron emission tomography (PET)-computed tomography (CT) in detection of local recurrence of colorectal cancer is evaluated in 71 patients, selected due to suspected relapse at CT follow-up. Recurrence was confirmed by histology in 18 cases and excluded in 25 cases. Sensitivity, specificity, positive and negative predictive values, and accuracy were as follows: 44.4%, 92.5%, 66.7%, 83.1%, and 80.3% for CEA; 88.9%, 73.6%, 53.3%, 95.1%, and 77.5% for MRI; and 94.4%, 73.6%, 54.8%, 97.5%, and 78.9% for PET-CT. A diagnostic protocol integrating CEA and dedicated imaging studies is to be advocated
Scintimammography with 99mTc-MIBI and magnetic resonance imaging in the evaluation of breast cancer
No full textThis study was performed to evaluate the sensitivity and specificity of technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) scintimammography (SMM) and contrast-enhanced magnetic resonance imaging (MRI) in patients with breast masses, using the histological findings as the gold standard. Forty-five consecutive patients with a breast lesion, detected by self-examination, physical examination or screening mammography, underwent SMM and MRI. In 38 cases (84.5%), the histopathology was malignant; the breast cancers ranged from 3 to 100 mm in diameter (mean 22 mm). In the overall patient group, MRI showed a slightly higher sensitivity than SMM (92% vs 84%), but SMM showed a better specificity: 71% vs 42%. The accuracy was 82% and 84% for SMM and MRI respectively. To evaluate the influence of lesion size on the results, patients with lesions ≤20 mm and ≤15 mm were examined. In patients with lesions ≤20 mm, the sensitivity of SMM and MRI decreased to 64% and 82% respectively, while SMM again displayed considerably better specificity: 83% vs 50% for MRI. The accuracy of SMM and MRI was 64% and 82% respectively. In patients with lesions ≤15 mm, SMM again showed better specificity (75% vs 50%), while MRI displayed better sensitivity and accuracy (sensitivity, 81% vs 62%; accuracy, 75% vs 65%). In this study the specificity of SMM in patients with breast lesions was thus superior to that of MRI. The combination of SMM and MRI may be used in those patients with equivocal findings at mammography and ultrasound to reduce the number of unnecessary surgical biopsies
Sensitivity and specificity of scintimammography versus magnetic resonance imaging: a comparison in 58 patients with breast lesions using histology as a gold standard
No full textIn our study the MRI and scintimammography sensitivity resulted to be superimposable, whereas specificity is greatly in favour of scintimammography: thus, we believe that in the specific clinical conditions, such as in dense breast and in multifocal breast cancer, scintimammography colud be a great help
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