112,172 research outputs found
Reply to the letter to the editor 'Erroneous conclusions about the association between light alcohol drinking and the risk of cancer: comments on Bagnardi et al.'s meta-analysis, by S.-K. Myung'
No full textLabour Process Theory: taking stock and looking ahead
No full textThe article critically reconstructs the trajectory of the Labour Process Theory debate from Braverman onwards. It analyses the second wave classics and the principal underpinnings of the so-called core labour process theory. It describes the debate spurred by the formalization of the core theory vis-à-vis changing productive structures. It identifies a few threads of fruitful internal debate that are crucial for the analysis of current trends and transformation of work: the missing subject, the connectivity gap, and the role of technology. The ways in which the internal debate have tackled the issue raised seems promising of an open and lively debate that reasserts the relevance of the Labour Process Theory as an analytical framework that remain crucial in the current sociology of work
Eruption at basaltic calderas forecast by magma flow rate
No full textUsing magma inflow rate improves eruption forecasting on timescales of weeks to months for basaltic caldera systems, compared with using surface deformation alone, according to analysis of 45 unrest case studies and viscoelastic modelling.Forecasting eruption is the ultimate challenge for volcanology. While there has been some success in forecasting eruptions hours to days beforehand, reliable forecasting on a longer timescale remains elusive. Here we show that magma inflow rate, derived from surface deformation, is an indicator of the probability of magma transfer towards the surface, and thus eruption, for basaltic calderas. Inflow rates >= 0.1 km(3) yr(-1) promote magma propagation and eruption within 1 year in all assessed case studies, whereas rates <0.01 km(3) yr(-1) do not lead to magma propagation in 89% of cases. We explain these behaviours with a viscoelastic model where the relaxation timescale controls whether the critical overpressure for dyke propagation is reached or not. Therefore, while surface deformation alone is a weak precursor of eruption, estimating magma inflow rates at basaltic calderas provides improved forecasting, substantially enhancing our capacity of forecasting weeks to months ahead of a possible eruption
A meta-analysis of alcohol drinking and cancer risk
No full textTo evaluate the strength of the evidence provided by the epidemiological literature on the association between alcohol consumption and the risk of 18 neoplasms, we performed a search of the epidemiological literature from 1966 to 2000 using several bibliographic databases. Meta-regression models were fitted considering linear and non-linear effects of alcohol intake. The effects of characteristics of the studies, of selected covariates (tobacco) and of the gender of individuals included in the studies, were also investigated as putative sources of heterogeneity of the estimates. A total of 235 studies including over 117 000 cases were considered. Strong trends in risk were observed for cancers of the oral cavity and pharynx, oesophagus and larynx. Less strong direct relations were observed for cancers of the stomach, colon and rectum, liver, breast and ovary. For all these diseases, significant increased risks were found also for ethanol intake of 25 g per day. No significant nor consistent relation was observed for cancers of the pancreas, lung, prostate or bladder. Allowance for tobacco appreciably modified the relations with laryngeal, lung and bladder cancers, but not those with oral, oesophageal or colorectal cancers. This meta-analysis showed no evidence of a threshold effect for most alcohol-related neoplasms. The inference is limited by absence of distinction between lifelong abstainers and former drinkers in several studies, and the possible selective inclusion of relevant sites only in cohort studies
Noneruptive unrest at the caldera of Alcedo Volcano (Galápagos Islands) revealed by InSAR data and geodetic modelling.
No full textGlobal distribution of prophylactic total gastrectomy in E-cadherin (CDH1) mutations
No full textIndividuals with germline E-cadherin (CDH1) mutations are at high risk of developing diffuse gastric cancer (GC) and prophylactic total gastrectomy (PTG) represents the only life-saving treatment. We reviewed all PTGs reported in literature associated with CDH1 germline mutations. A total of 224 PTGs were reported. The majority were described in the United States of America (50%), the Netherlands (17.8%), and Canada (12.5%). GC was identified in 85.4% of cases after PTG, with a high rate of “no cancer” at histopathology identified in the United States of America (19.6%). Considering the mutation type, a total of 61 different germline mutations was reported, primarily non-missense versus missense alterations (86.9% v 13.1%). Twenty-one PTGs were performed in individuals with no family history of GC, and tumor was detected in 33.3% of investigated cases; regarding individuals with a family history of GC, tumor was identified in 85% of cases. PTG remains the best treatment for individuals harboring germline CDH1 mutations and fulfilling specific clinical criteria; in other CDH1-associated conditions, PTG should be suggested, but not strongly recommended. Additional studies are required to assess the cancer risk in those conditions
Epidemiology and pathophysiology of alcohol and breast cancer : Update 2012
No full textAims: To update epidemiological data on alcohol and breast cancer, with special emphasis on light alcohol consumption, and to review mechanisms of alcohol mediated mammary carcinogenesis. Methods: For epidemiological data, in November 2011 we performed a literature search in various bibliographic databases, and we conducted a meta-analysis of data on light alcohol drinking. Relevant mechanistic studies were also reviewed to November 2011. Results: A significant increase of the order of 4% in the risk of breast cancer is already present at intakes of up to one alcoholic drink/day. Heavy alcohol consumption, defined as three or more drinks/day, is associated with an increased risk by 40-50%. This translates into up to 5% of breast cancers attributable to alcohol in northern Europe and North America for a total of approximately 50 000 alcohol-attributable cases of breast cancer worldwide. Up to 1-2% of breast cancers in Europe and North America are attributable to light drinking alone, given its larger prevalence in most female populations when compared with heavy drinking. Alcohol increases estrogen levels, and estrogens may exert its carcinogenic effect on breast tissue either via the ER or directly. Other mechanisms may include acetaldehyde, oxidative stress, epigenetic changes due to a disturbed methyl transfer and decreased retinoic acid concentrations associated with an altered cell cycle. Conclusions: Women should not exceed one drink/day, and women at elevated risk for breast cancer should avoid alcohol or consume alcohol occasionally only
The 2008 eruptive unrest at Cerro Azul volcano (Galápagos) revealed by InSAR data and a new method for geodetic modelling.
No full textA meta-analysis of alcohol consumption and the risk of 15 diseases
No full textBACKGROUND: To compare the strength of evidence provided by the epidemiological literature on the association between alcohol consumption and the risk of 14 major alcohol-related neoplasms and non-neoplastic diseases, plus injuries. METHODS: A search of the epidemiological literature from 1966 to 1998 was performed by several bibliographic databases. Meta-regression models were fitted considering fixed and random effect models and linear and nonlinear effects of alcohol intake. The effects of some characteristics of the studies, including an index of their quality, were considered. RESULTS: Of the 561 initially reviewed studies, 156 were selected for meta-analysis because of their a priori defined higher quality, including a total of 116,702 subjects. Strong trends in risk were observed for cancers of the oral cavity, esophagus and larynx, hypertension, liver cirrhosis, chronic pancreatitis, and injuries and violence. Less strong direct relations were observed for cancers of the colon, rectum, liver, and breast. For all these conditions, significant increased risks were also found for ethanol intake of 25 g per day. Threshold values were observed for ischemic and hemorrhagic strokes. For coronary heart disease, a J-shaped relation was observed with a minimum relative risk of 0.80 at 20 g/day, a significant protective effect up to 72 g/day, and a significant increased risk at 89 g/day. No clear relation was observed for gastroduodenal ulcer. CONCLUSIONS: This meta-analysis shows no evidence of a threshold effect for both neoplasms and several non-neoplastic diseases. J-shaped relations were observed only for coronary heart disease
Alcohol consumption and the risk of cancer: A meta-analysis
No full textAlcohol consumption has been linked to an increased risk for various types of cancer. A combined analysis of more than 200 studies assessing the link between alcohol and various types of cancer (i.e., a meta-analysis) sought to investigate this association in more detail. This meta-analysis found that alcohol most strongly increased the risks for cancers of the oral cavity, pharynx, esophagus, and larynx. Statistically significant increases in risk also existed for cancers of the stomach, colon, rectum, liver, female breast, and ovaries. Several mechanisms have been postulated through which alcohol may contribute to an increased risk of cancer. Concurrent tobacco use, which is common among drinkers, enhances alcohol's effects on the risk for cancers of the upper digestive and respiratory tract. The analysis did not identify a threshold level of alcohol consumption below which no increased risk for cancer was evident
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