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RADIOIMMUNOGUIDED SURGERY BENEFITS IN CEA ANTIGEN-DIRECTED SECOND LOOK SURGERY IN THE ASYMPTOMATIC PATIENTS AFTER CURATIVE RESECTION OF COLORECTAL CANCER
No full text[Bacterial control in the operating room].
No full textThirty-nine patients with liver tumours have been submitted to regional arterial
chemotherapy by means of either totally implantable Infusaid-400 pumps (22 c.) or
implantable ports (17 c.). The latter were subsequently perfused with external
pumps. There was one single major operative complication and no operative deaths.
Most patients underwent continuous Fudr infusion. Access related complications
occurred in both groups. Treatment was stopped for access related complications
in 18.4% and 29.4% of cases out of the pump and port groups respectively. In most
of those cases, however, several cycles of chemotherapy had already been
performed. The Infusaid-400 pumps showed a 12-month functional duration of 57%
with a 13-month median, the 10-month duration of ports being 67%. The difference
was not significant. The new implantable systems give better results in
comparison with traditional regional access methods, the functional performances
of the port systems appearing very similar to the totally implantable pumps, with
an obvious advantage for the pumps as far as quality of life is concerned
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Role of diagnostic lymphnode biopsies in 56 anti-HIV positive patients.
No full textThe authors have examined two separate series of samples from 33 and 23 anti-HIV
positive patients with persistent generalized lymphadenopathy (PGL) undergoing
lymphnode biopsy. For the first group of patients, the aim was to evaluate the
diagnostic and prognostic correlation between clinical and laboratory features
and histologic findings. For the second group, an assessment was made of the
indications for lymphnode biopsy as determined by the rate of positive
histopathologic findings. Histologic alterations were classified into four types
according to Ràcz, without knowledge of clinical and laboratory data. At the time
of biopsy, the first sample (n = 33) included 21 lymphadenopathy associated
syndrome (LAS) (64%), 6 ARC (18%), and 6 AIDS (18%) patients; a significant
prevalence of type 1 histologic features was evident in LAS/ARC patients, while
type 4 was exclusively present in the AIDS group. These preliminary results
suggested that only symptomatic anti-HIV positive patients (ARC/AIDS) should have
been selected for lymphnode biopsy, because of the expected high rate of
opportunistic infections, malignant lymphoma, or Kaposi's sarcoma (KS) in this
specific subset of patients. Actually, in the second sample of 23 patients (ARC =
8: AIDS = 15) the detection rate of AIDS-related neoplasms included ten Kaposi's
sarcoma and three Hodgkin's disease. These findings suggest that diagnostic
lymphnode biopsies should be limited to selected anti-HIV positive patients with
evidence of AIDS-related neoplasms or treatable opportunistic infections, or for
the purpose of detecting histopathologic features of prognostic significance
Lymph node biopsy in the diagnostic and prognostic assessment of patients with HIV infection.
No full textThirty-three anti-HIV positive patients with persistent generalized
lymphadenopathy (PGL) who underwent lymph-node biopsy were studied to assess the
diagnostic and prognostic relations existing between clinical, histological and
laboratory findings. Patients were also examined for known risk factors,
laboratory and bacteriological tests, and mononuclear cell surface marker
analysis. 4 histological types were identified according to Ràcz's
classification. At biopsy, there were 21 cases of LAS (64%), 6 cases of ARC (18%)
and 6 cases of AIDS (18%); a clear prevalence of type 1 was evidenced in LAS/ARC
patients, while only type 4 was present in the AIDS group. An ARC type 3 patient
developed manifest AIDS within 13 months from biopsy. These results suggest that
anti-HIV positive asymptomatic patients with PGL apparently do not require lymph
node biopsy, as none of them showed histologic findings suggestive of
opportunistic infections, malignant lymphoma or Kaposi's sarcoma. On the
contrary, lymph node biopsy can play a diagnostic and prognostic role in anti-HIV
negative subjects with PGL, and in ARC and AIDS patients
Concomitant chemo-radiotherapy in the treatment of locally advanced and/or metastatic soft tissue sarcomas: Experience of the National Cancer Institute of Genoa.
No full textComputer-Aided Locoregional Assessment of Soft Tissue Sarcoma and Three-Dimensional Simulator Surgery
No full textUse of radioimmunoguided surgery after induction chemotherapy in locally advanced breast cancer.
No full textAbstract
Twenty-one patients with histologically proven locally advanced breast cancer (LABC) were treated with a combined modality approach based on primary chemotherapy and radical modified mastectomy followed by adjuvant chemotherapy. Surgery was performed by using radioimmunoguided surgery (RIGS) technique with the preoperative injection of Iodine-125 labeled monoclonal antibodies (MoAbs) B72.3 anti-TAG (11 patients, Group A) and FO23C5 anti-carcinoembryonic antigen (CEA; 10 patients, Group B). The role of RIGS was defined at surgery by using an intraoperative hand-held gamma-detecting probe (GDP) to locate the primary tumor, possible clinically occult multicentric foci and ipsilateral lymph node metastases. In Group A, RIGS correctly defined the primary tumor in seven out of 11 patients (63.3%) and was able to find multicentric tumors in two out of four patients (50%). Positive lymph nodes were identified by RIGS in three out of eight patients (37.5%). In Group B, patients RIGS correctly located the primary in 4/10 cases (40%); in two RIGS-positive cases, the tumor was clinically not evident after primary chemotherapy (yT0). RIGS correctly identified multicentric foci of tumor in one out of two cases (50%). Correct lymph nodal RIGS assessment was observed in three out of nine patients (33.3%). No RIGS false-positive findings occurred in the 21 patients included in the study. RIGS appears to be a reliable technique for the intraoperative diagnosis and staging of breast cancer with a potential role especially when conservative surgery is planned after primary chemotherapy in LABC
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