1,721,011 research outputs found
The relation of season of birth to severity of menopausal symptons
No full textObjective: Season of birth influences the rate of several psychiatric disorders. In this study,
we investigated whether climacteric symptoms and, in particular, psychological and somatic
symptoms of postmenopausal women were influenced by their season of birth.
Design: This retrospective multicenter study was performed on 2,541 women in natural
menopause, free of hormone therapy. The score of the Greene Climacteric Scale and of its
vasomotor, psychological (anxiety and depression), and somatization subscales were stratified by
season of a woman`s birth. Data were controlled for possible confounders, such as age, years since
menopause, body mass index, education occupation, smoking habits, and season of evaluation.
Results: The Greene Climacteric Scale appeared to be associated with the season of birth,
with the lowest scores being observed in women born in autumn and the highest scores in
women born in spring (+2.11; 95% CI, 0.67-3.56; P = 0.01) and summer (+2.22; CI, 0.82-3.63;
P = 0.01). Lowest scores in autumn and highest scores in spring were also observed for
psychological symptoms subscaled as anxiety and depression (+1.43; CI, 0.54-2.32; P = 0.01)
and somatic symptoms (+0.59; CI, 0.15-1.04; P = 0.01).
Conclusions: In this study, we found a relationship between season of birth and some
menopause-associated symptoms. Further study is needed to confirm these relationships and
examine possible mechanisms
Distacco bilaterale di retina e diabete insipido transitorio del postpartum in gravidanza complicata da HELLP Sindrome
No full textEffect of soy-derived isoflavones on hot flushes, endometrial thickness, and the pulsatility index of the uterine and celebral arteries
No full textNeutral effect of prolonged transdermal hormone therapy on liver function in postmenopausal women with chronic active hepatitis
No full textObjective: To test whether transdermal hormone therapy can be safely administered to postmenopausal
women with chronic viral hepatitis B and/or C.
Design: Eighty-one postmenopausal women with chronic viral hepatitis B and/or C and with
severe vasomotor symptoms were treated for 5 years with transdermal estradiol (50 mg/day) continuously
and with transdermal norethisterone (250 mg/day) for 14 days of every 28-day cycle.
Another 95 women with viral chronic hepatitis but without climacteric symptoms were used
as controls. Liver enzymes (glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase,
g-glutamine-transferase, and alkaline phosphatase) were measured every year.
Results: At baseline, liver enzymes were similar in the two groups, with the exception of g-GT,
which was slightly higher in untreated women (P , 0.01). Liver enzymes did not significantly vary
with time in hormone-treated and untreated women. No significant difference was observed between
the two groups.
Conclusions: Transdermal estradiol and norethisterone can be safely administered for a prolonged
period to postmenopausal women with chronic viral B and/or C hepatitis
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