81 research outputs found
Development of novel chiral capillary electrophoresis methods for the serotonin receptor (5-HT2A) antagonist MDL 100,907 (volinanserin) and for its key intermediate compound
No full textEnantioselective capillary electrophoretic methods were elaborated for the determination of the enantiomeric purity of (R)-MDL 100,907 and its preparatively resolved key intermediate compound during the synthesis route. The pKa values of the intermediate compound and the end product determined by CE were 10.5±0.1 and 9.0±0.1, respectively. The enantiopurity of the intermediate compound can be monitored in fully protonated state by applying 15mM sulfobutylether-β-cyclodextrin at pH 5 when the peak belonging to the impurity migrates before the main component. The fact that the consecutive steps of the synthesis do not affect the enantiomeric purity was verified by the other, newly developed CE method. The enantiomers of rac-MDL 100,907 were resolved by 15mM carboxymethyl-γ-cyclodextrin at pH 3. The applicability (selectivity, LOD, LOQ, repeatability, precision and accuracy) of the methods was studied as well
Helicobacter pylori Infection as a Triggering Factor of Attacks in Patients with Hereditary Angioedema
No full textBackground: Helicobacter pylori infection is considered among the causative factors of urticaria and angioedema. Having conducted a study on 65 patients, Hungarian authors reported in 2001 that successful eradication of H. pylori is followed by a significant reduction in the number of attacks in patients with hereditary angioedema (HAE). The present study aimed to reinvestigate the relationship between H. pylori infection and the attack rate in the framework of an international collaborative study. Materials and methods: Within the framework of the PREHAEAT project launched by the European Union, further 152 patients were studied in seven collaborating centers, and participants of the earlier study were followed up in order to detect any relationship between H. pylori infection and the occurrence of attacks in patients suffered from HAE. Results: The proportion of patients experiencing frequent (≥ 5 per year) abdominal attacks was higher (p =.002) among the H. pylori-infected participants of the international study who underwent eradication as compared to the rest of patients. Successful eradication of H. pylori significantly (p =.0006) reduced the number of attacks in these patients as well. Nine subjects of the previous Hungarian study who underwent eradication therapy for dyspepsia were followed up for an additional 4 years. In these patients, attack frequency remained consistently low. Conclusions: As shown by experience from the Hungarian and the international trial, the number of frequent, edematous abdominal attacks may decrease substantially following the eradication of H. pylori from HAE patients infected with this pathogen. Therefore, screening of patients with HAE for H. pylori infection seems warranted. Eradication of H. pylori may lead to a marked reduction in disease severity
Recensiones
No full textZs. Visy: A ripa Pannonica Magyarországon [Die ripa Pannonica in Ungarn]. Akadémiai Kiadó, Budapest 2000, 144 S., 180 Abb., 28 Karten; A. Pasquier (ed.): Olympie.Cycle de huit conférences or ganisé au Musée du Louvre par le Service Culturel du 18 janvier au 15 mars 1999, Paris. La documentation Française. Paris 2001, 282 s
Effect of washing and refining on Visy paper quality
No full textThis thesis was scanned from the print manuscript for digital preservation and is copyright the author.
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La Integración Colombo-Venezolana: Reflexiones para una Publicidad y Mercado Integracionista
No full textFrente a la competencia de los bloques económicos y la reestructuración que está sufriendo la economía global, la autora considera necesario volver a plantear el viejo tema de la integración entre Colombia y Venezuela, proceso en el cual la publicidad juega un papel importante como forma comercial de amblio impacto en términos económicos y culturales. Se describe la cultura económica de ambos países y las características del comercio binacional presentando las ventajas derivadas de la integración. Las imágenes y estereotipos que forman parte de la cultura actitudinal de los dos pueblos son el cambo donde el publicista puede salvar brechas político-culturales y convertirse en un factor de conexión. Concluye exponiendo la actividad publicitaria de los países y las oportunidades o retos profesionales que la integración ofrece a los publicistas y empresarios de la comunicación.AbstractFacing the competence of the economic blocks and the restructuration that is suffering global economy, the author considers necessary to outline again the old theme of integration between Colombia and Venezuela, process in which publicity plays an important role as a commercial form of vast impact in economical and cultural terms. The economic culture of both countries is described, as also the characteristics of binational commerce, presenting the advantages derived form integration. The images and stereotypes that are part of the cultural attitude of both countries are fields where the publicist can save political and cultural gaps, and become a factor of connection. The author concludes expounding the advertising activity of both countries and the professional challenges that integration offers to publicist and managers of communication
Kazincbarcika környezetvédelmi szabályozása, különös tekintettel a levegővédelemre
No full textA dolgozat bemutatja Kazincbarcika és térsége környezetvédelmi helyzetét,annak helyi szabályozását. Kérdőíves felmérés alapján vizsgálja a Kazincbarcikán élő lakosság ismeretét, tudását a helyi önkormányzat környezetvédelmi tevékenységével kapcsolatosan. A dolgozat kitér a világban jelenlévő környezeti problémákra, de leginkább a levegővédelemmel foglalkozik, mivel Kazincbarcikán ez a legfőbb megoldandó probléma. Ugyanis a város szélén üzemel Magyarország egyik legnagyobb vegyipari vállalata, melynek nagy szerepe lehet a károsanyag kibocsátásban és a légszennyezésben. Emellett a település forgalmas utak mellett helyezkedik el, így a közlekedés okozta légszennyezés is elkerülhetetlen. Nem utolsó sorban a városban és környékén még mindig magas a helytelen háztartási fűtések, tüzelések száma, így ez is jelentősen hozzájárul a levegő minőségéhez. A dolgozat elemzi Kazincbarcika Város Környezetvédelmi Programját, statisztikai adatokkal támasztja alá a településen bekövetkező környezetvédelmi intézkedéseket.Bemutatja azokat a kémiai vegyületeket, amik szennyezik a levegőt. A dolgozat tartalmaz elrettentő adatokat, a város levegőminőségének romlásáról és azok negatív hatásáról. Végezetül a dolgozat próbál megoldást találni a jelenlegi környezeti problémákra és megjelenik a fenntarthatóság elve is, hogy maga a Föld és az emberek, egészségüket megőrizve tovább élhessenek.igazságügyi igazgatási szakBSc/B
Characterisation and textural analysis of Middle Bronze Age Transdanubian inlaid wares of the Encrusted Pottery Culture, Hungary: a preliminary study
No full textInlaid ceramics belonging to the Encrusted Pottery Culture and dated to the Middle Bronze Age (2000–1500 BC) are highly distinctive vessels with complex decorative motifs found in large numbers in the Transdanubia region of Hungary. Despite this considerable corpus of material there has been little systematic investigation of the composition of the inlays. Micro-analysis of Transdanubian inlaid wares by X-ray diffraction (XRD), micro-Fourier transform infrared microscopy (FT-IR), and scanning electron microscopy (SEM) provides new compositional, structural and textural information on the inlays. In contrast to common statements in the literature regarding the materials used to make inlays, these new data show that the majority of inlays are composed of hydroxyapatite (bone) that was previously ashed, although some of the inlays are composed of calcium carbonate. Additional compositional and textural variation in the bone inlays suggests that bone material from different skeletal elements and/or of different age may have been used, and that contrasting recipes for inlay preparation were employed during fabrication. These results suggest that the production of inlaid vessels of the Encrusted Pottery Culture was more complex than has hitherto been thought
Ink particle removal @ Visy Paper 4 de-inking line, through cleaner selection and dispersion optimisation
No full textThis thesis was scanned from the print manuscript for digital preservation and is copyright the author.
Researchers can access this thesis by asking their local university, institution or public library to
make a request on their behalf. Monash staff and postgraduate students can use the link in the References field
Investigation of and optimisation of the chemical de-inking process at Visy Paper 4
No full textThis thesis was scanned from the print manuscript for digital preservation and is copyright the author.
Researchers can access this thesis by asking their local university, institution or public library to
make a request on their behalf. Monash staff and postgraduate students can use the link in the References field
The evolution of roman frontier defence systems and fortifications the lower danube provinces in the first and second centuries AD
No full textThe defence of the Roman Empire from barbarian attacks depended on two distinct but interrelated features: the actual fortifications on the borders of the imperial provinces and the troops that garrisoned them. The main aim of this dissertation is to provide a collective analysis of Roman defence systems on the Lower Danube region, i.e. the provinces of Pannonia Inferior, Moesia Superior, Moesia Inferior and Dacia. The period of study spans from the early first century to the middle of the second century AD, a period which corresponds to the gradual emergence and final consolidation of the Roman frontier defence systems in the area. On the basis of the physical evidence that has survived from the frontier fortifications of the Lower Danube area, this study attempts to present a reconstruction of the strategic and tactical situation on the frontier and to provide some fresh observations on the motives behind the creation, purpose and function of Roman frontiers during the early Principate. After a brief introduction on some of the views that have been put forward on the subject, the main part of the thesis is divided into four separate chapters, one for each of the provinces studied. These chapters study the fortifications themselves in order to establish their date and garrison so as to offer an evaluation of the characteristic features of the defensive system of each frontier sector. The last chapter brings together the above information in order to produce some conclusions on the defence systems in the area, especially in relation to the rationale behind their creation and subsequent development
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