1,721,004 research outputs found
Analysis of p16 protein expression in familial melanoma patients: correlation with germline status.
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Androgens and estogens modulate the immune and inflammatory responses in rheumatoid arthritis.
No full textTestosterone induces cell apoptosis acting at different stages: effects on rheumatoid synovial macrophages and activated human monocytic cells (THP-1)
No full textAndrogen metabolism and aptosis in cyclosporin-treated primary cultures of human synovial macrophages.
No full textAntiproliferative-antiinflammatory effects of methotrexate (MYX) and sex hormones on cultured differentiating myeloid monocytic cells (THP-1)
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Basic and clinical aspects of the sex hormone influence on the immune responce IV European Congress on Menopause
No full textApoptosis induced by serum withdrawal in human mesangial cells. Role of IGFBP-3
No full textApoptosis has been reported to occur both during the course of kidney development and the progression of kidney injury to scarring. Insulin-like growth factor binding protein-3 (IGFBP-3), a component of the IGF system, has been shown to induce apoptosis in cancer cell lines. However, if IGFBP-3 has similar effects in human mesangial cells (HMC) remains unknown. The purpose of this study was to examine the expression of IGFBP-3 and its possible effect on the induction of apoptosis in HMC during serum deprivation. We have observed that IGFBP-3 accumulates progressively in HMC in which serum has been withdrawn. In these cells, an increase of IGFBP-3 is observed before the production of apoptosis suggesting a link between these phenomena. Furthermore, the addition of IGFBP-3 in physiological amounts (from 100 to 400 ng/ml) to culture medium devoid of growth factors accelerates and increases the apoptotic process with a dose-dependent effect. These findings suggest that IGFBP-3 is a mediator of cell death in human mesangial cells when the availability of growth factors is curtailed. These data also suggest that IGFBP-3 could contribute to apoptotic processes observed in human diseas
New aspects and mechanisms of action of cyclosporin A in psoriatic arthritis:the role of sex hormones
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