20 research outputs found
Volatile organic pollutants: Levels, fate and ecotoxicological impacts. Proceedings of the 2nd IMTOX Workshop
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Zur Frage der Verknüpfung kognitiver Lerninhalte und klinisch diagnostischer Anwendung in der vorklinischen Neuroanatomie Vorlesung
No full textStructural change of the Phe-tRNAPhe(CCCA) and the effect on the rate of peptide formation
No full textEffect of the presence of a pCpCpCA 3′-terminus in Phe-tRNAPheyeast on the interaction with elongation factors and with the poly U-ribosome system
No full textInhibition of TNF-alpha promoter activity and synthesis by A11-99-1, a new cyclopentenone from the ascomycete Mollisia melaleuca
No full textIn a search for inhibitors of the inducible tumor necrosis factor-alpha (TNF-alpha) promoter activity and synthesis, a new chlorinated cyclopentenone was isolated from fermentations of the ascomycete Mollisia melaleuca. The structure was determined by a combination of spectroscopic techniques. The compound blocked the inducible human TNF-alpha promoter activity and synthesis with IC50-values of 2.5-5 mu g/ml (8.1-16.1 mu M). Studies on the mode of action of the compound revealed that the inhibition of TNF-alpha promoter activity is caused by an inhibition of the phosphorylation of the I kappa B protein which prevents the activation of the transcription factor NF-kappa B. No cytotoxic, antibacterial and antifungal activities could be observed up to 100 mu g/ml (323 mu m) of the compound
Inhibition of TNF-alpha promoter activity and synthesis by A11-99-1, a new cyclopentenone from the ascomycete Mollisia melaleuca [Elektronisk resurs]
No full textIn a search for inhibitors of the inducible tumor necrosis factor-alpha (TNF-alpha) promoter activity and synthesis, a new chlorinated cyclopentenone was isolated from fermentations of the ascomycete Mollisia melaleuca. The structure was determined by a combination of spectroscopic techniques. The compound blocked the inducible human TNF-alpha promoter activity and synthesis with IC50-values of 2.5-5 mu g/ml (8.1-16.1 mu M). Studies on the mode of action of the compound revealed that the inhibition of TNF-alpha promoter activity is caused by an inhibition of the phosphorylation of the I kappa B protein which prevents the activation of the transcription factor NF-kappa B. No cytotoxic, antibacterial and antifungal activities could be observed up to 100 mu g/ml (323 mu m) of the compound
Benzo(a)pyrene induces nuclear-DNA adducts in plant cell suspension culture Detection by [32P] postlabelling
No full textAbstractUsing a [32P] postlabelling technique, we found that plant cells (Echinacea purpurea) cultured in the presence of benzo(a)pyrene form nuclear DNA adducts
Strömungsmodelle zur Analyse und Optimierung von komplexen Systemen in transienten Zuständen
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