806 research outputs found
Fludarabine and prednisone in pretreated refractory B-chronic lymphocytic leukemia (B-CLL) in advanced stages
No full textBackground. The use of fludarabine, an analog of vidarabine with significant lymphocytolytic activity, has provided encouraging results in the treatment of patients with non Hodgkin's lymphoma (NHL) and sometimes in phase II studies of solid tumors and acute leukemias. Fludarabine has also been shown to be effective in B-CLL. Some studies referred results using fludarabine in high-risk untreated or pretreated CLL patients.
Methods. We report treatment results with fludarabine and prednisone in 22 pretreated B-CLL patients in progressive disease, refractory to CHL and other regimens.
Results. One patient obtained a complete response (CR), 8 obtained a partial response (PR). Thirteen failed to respond to treatment. Among the partial responders, 1 patient had fatal pneumonia while neutropenic, another died of disease progression. Among the non responders, 7 died of progressive disease, and 3 evolved into high-grade NHL. Three are still alive in disease progression.
Conclusions. We confirm the effectiveness of fludarabine in pretreated and resistant B-CLL, but in the light of the considerable toxicity observed in this series, we believe that the drug would be better employed as a first-line approach to > untreated B-CLL patients
Regolazione ambientale e politiche energetiche: Il dibattito attuale nei contributi di «Energy Policy»
No full textIn order to focus attention on issues at the heart of the economic debate concerning the energy markets, the work summarizes the relevant articles published by the journal Energy Policy. The issues raised were: a) Energy Policies for Low Carbon Sustainable Transport in Asia: b) Energy Markets' Financialization, Risk Spillovers, and Pricing Models; c) Challenges for R&D nd Innovation in Energy; d) Conditioning Demand: Older People, Thermal Comfort and Low-Carbon Housing; e) The Regional Integration of Energy Markets; f) The enigma of economic growth: Beyond Solow-type macroeconomic perspectives; g) UK Energy Policies and Strategies under Uncertainty; h) Energy markets and policy implications
Reseña de Monarca, H. y Thoilliez, B. (Coords.) (2017). La profesionalización docente. Debates y propuestas. Madrid: Síntesis.
No full textReseña de Monarca, H. y Thoilliez, B. (Coords.) (2017). La profesionalización docente. Debates y propuestas. Madrid: Síntesis
Recombinant alpha 2b interferon (alpha-2b-IFN), chlorambucil, and prednisone in advanced chronic lymphocytic leukemia (CLL)
No full textNo abstract availabl
Immunohistochemical characterization of a B-cell signet ring cell lymphoma. Report of a case.
No full textMonitoring of alcohol, tobacco and psychoactive medicine consumption in the Umbria region of Italy.
No full textLack of specific association between gastric autoimmunity hallmarks and clinical presentations of atrophic body gastritis
No full textMeteorological observations during El Monarca cruise from Montevideo to Santa Catalina started at 1778-03-11
No full textMeteorological observations during El Monarca cruise from Montevideo to Santa Catalina started at 1778-03-1
Meteorological observations during El Monarca cruise from Montevideo to Santa Catalina started at 1777-05-14
No full textMeteorological observations during El Monarca cruise from Montevideo to Santa Catalina started at 1777-05-1
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