202 research outputs found
DOPAMINE D2-LIKE RECEPTORS AND DOPAMINE INNERVATION IN THE RAT CAUDATE-PUTAMEN. AN AUTORADIOGRAPHIC AND IMMUNOCYTOCHEMICAL STUDY.
No full textThe aim of study was to compare, in the rat caudate-putamen (CP), quantitative autoradiography data on the [125I]-NCQ298 binding sites and the Tyrosine Hydroxylase (TH)-like immunoreactive fibers distribution, mostly with regards to differences between medial and lateral subregions of CP
Au Revoir, Chantal [French]
No full textArticle translated and adapted in French on Chantal Akerman the artist and her exhibition at Ambika P3 curated by the author in the context of her untimely death
Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection
No full textRituximab, a monoclonal antibody which targets CD20 on B-cells, is now central to the treatment of a variety of malignant and autoimmune disorders. Despite this success a substantial proportion of B-cell lymphomas are unresponsive or develop resistance, hence more potent anti-CD20 mAb are continually being sought. Here we demonstrate that type II (tositumomab-like) anti-CD20 mAb are 5 times more potent than type I (rituximab-like) reagents in depleting human CD20 Tg B-cells, despite both operating exclusively via activatory FcR-expressing macrophages. Much of this disparity in performance is attributable to type I mAb-mediated internalization of CD20 by B-cells leading to reduced macrophage recruitment and the degradation of CD20:mAb complexes, shortening mAb half-life. Importantly, human B cells from healthy donors, and most cases of Chronic Lymphatic Leukemia (CLL) and Mantle Cell Lymphoma, showed rapid CD20 internalization which paralleled that seen in the Tg mouse B cells, while most Follicular Lymphoma (FL) and Diffuse Large B-Cell Lymphoma (DLBCL) cells were far more resistant to CD20 loss. We postulate that differences in CD20 modulation may play a central role in determining the relative efficacy of rituximab in treating these diseases and strengthen the case for focusing on type II anti-CD20 mAb in the clinic. <br/
Au Revoir, Chantal
No full textArticle on Chantal Akerman the artist and her exhibition at Ambika P3 curated by the author in the context of her untimely death
Stimulation des lymphocytes B in vitro par le DSP30 et l'IL2 (évaluation dans le cadre de l'étude cytogénétique des lymphomes non-hodgkiniens à petites cellules en phase leucémisée)
No full textLa leucémie lymphoïde chronique et les lymphomes non hodgkiniens sont des pathologies dont la fréquence a fortement progressé dans les pays industrialisés. Leur analyse cytogénétique est classiquement peu aisée du fait d une faible prolifération in vitro ce qui a beaucoup limité sa place dans la prise en charge des patients. Une nouvelle technique de stimulation des lymphocytes B en culture utilisant l oligonucléotide DSP30 et l interleukine 2 a été récemment décrite pour l analyse cytogénétique de la leucémie lymphoïde chronique. Le but de cette étude expérimentale est de déterminer l efficacité de cette nouvelle technique de culture dans le cadre de l ensemble des lymphomes B à petites cellules leucémisés indépendamment de leur nature et son apport effectif d un point de vue diagnostique et pronostique. La technique a été appliquée sur 41 échantillons, dont 14 cas de leucémie lymphoïde chronique et 27 cas de lymphomes B à petites cellules leucémisés. Nos résultats confirment son efficacité dans les cas de leucémie lymphoïde chronique et montrent des résultats positifs concernant le lymphome à cellules du manteau, le lymphome de la zone marginale et le lymphome lymphoplasmocytaire en phase leucémisée. Aucun cas de lymphome folliculaire leucémisé n'a pû être inclus. Les résultats des caryotypes se révèlent être contributifs sur les plans diagnostique et pronostique, en particulier dans les cas de leucémie lymphoïde chronique et de lymphome à cellules du manteau. Cette nouvelle technique peut permettre d améliorer la stratification thérapeutique des lymphoproliférations bien étiquetées, mais aussi de mieux cerner les formes frontières, de classement difficile.ANGERS-BU Médecine-Pharmacie (490072105) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Testing the Curatorial in Artists’ Film and Video Installation
No full textThis PhD by published work critically examines ten years of curatorial practice in the field of artists' film and video by the author. The aim of the thesis and publications is to question and challenge the contemporary integration of artists’ film and video installation into the language of the visual arts, the context of the white cube and the privileged definitions of curatorial practice. This PhD also places these questions in a historical context, taking into account the early and often overlooked developments of artists’ film and video exhibition.
This research was carried our through individual curatorial projects in the field by scrutinising specific constituent parts of artists’ film and video installation such as the screen, time, space, image, projection, site and audience. The curated exhibitions (the Projects) all took place at Ambika P3, a large postindustrial venue converted into a project space for this purpose in 2007. Each project manipulated these constituent elements and built on them in order to provide new artists’ commissions under the rigour of an experimental and research-led approach.
Through this commissioning process, this research developed new collaborative models of curatorial practice, examined and identified key critical areas of curatorial and artistic practice which have been overlooked by critics, writers, curators and the public and proposed new forms of artists’ film and video exhibition. This testing of the boundaries of artist’s film and video installation demonstrated that both the history and context of the practice is engaged with a broad range of paradigms inherited from cinema, sculpture and site specific practice. Furthermore it established that curation is a collective practice engaging numerous participants according to the needs and requirements of each project.
The projects revealed that a self reflexive and historically aware approach to curating artists’ film and video can deliver innovative and immersive works outside of the white cube, through an attention to materials, site and form. Through the publications and the commentary it is shown that a critical, collective and process based curatorial practice, attentive to context and its origins expands both the language and the power of the exhibited work
Retrieval of Tropospheric Information from Groundbased FTIR Observations, Supported by Synergistic Exploitation of Various Ground-based and Space-borne Measurement Techniques and Data
No full textMaking better sense of the mosaic of environmental measurement networks: a system-of-systems approach and quantitative assessment
No full textCardiotin localization in mitochondria of cardiomyocytes in vivo and in vitro and its down-regulation during dedifferentiation
No full textBackground: Cardiotin expression is observed in adult cardiac tissue. In the present study, we provide evidence for the specific localization of cardiotin in cardiac mitochondria and for its down-regulation during adaptive remodeling (dedifferentiation) of cardiomyocytes. Methods: Immunocytochemistry was used to study cardiotin localization in adult rabbit papillary muscle, in late-stage embryonic rabbit left ventricular tissue, and in left ventricle samples of rabbits suffering from pressure and volume overload. Western blot analysis of cardiotin was performed in purified pig heart mitochondrial fractions. Cardiotin expression was monitored in vitro in isolated adult rat and rabbit left ventricular cardiomyocytes. Results: Western blot analysis revealed the presence of cardiotin in the mitochondrial fractions of pig heart. Immunoelectron microscopy confirmed the presence of cardiotin in cardiac mitochondria of normal adult rabbits both in vivo and in vitro. Quantification of the localization of immunogold particles Suggests an association of cardiotin with the mitochondrial inner membrane. Cardiotin expression is initiated in late-stage ernbryonic rabbit heart, whereas in adult ventricular tissue cardiotin clearly stained longitudinal arrays of mitochondria. Pressure- and volume-overloaded myocardium showed a reduction in cardiotin expression in dispersed local myocardial areas. Cell cultures of adult cardiomyocytes showed a gradual loss in cardiotin expression in parallel with a sarcomeric remodeling. Conclusions: Our results demonstrate the specific localization of cardintin in adult cardiomyocyte mitochondria and propose its use as an early marker for cardiomyocyte adaptive remodeling and dedifferentiation. (C) 2009 Elsevier Inc. All rights reserved
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