206 research outputs found
Listen der Gebornen, Gestorbenen und Copulirten im Herzogthum Oldenburg von 1735 bis 1789 [CIM I 85 B]
No full text[Died. Heye]Verfasser auf Seite 17 genanntEntstehungsort und -datum auf Seite 17 ermittel
Der kleine Kinderfreund : Ein Büchlein für die lieben Kinder
No full textaus dem Holländischen des J. P. Heye übertragen von Karl Arenz. Mit Illustrationen von J. B. SonderlandVorlageform des Erscheinungsvermerks: Verlag von Aug. Wilh. Schulgen. - Buchdruckerei von Hermann VoßFarblithographienIn Fraktu
Fig1.Location of Heye Village and picture of retaining wall.
No full textLocation of Heye Village and picture of retaining wall.(a) (b)Reprinted from map data Open Street Map contributors, map layer by Mapbox, undera CC BY 4.0 license.</p
Forschungsbedingungen und Promotionsmöglichkeiten im Bereich Musikvermittlung an deutschsprachigen Hochschulen und Universitäten 2021
No full textHeye A, Voit J, Stiller B. Forschungsbedingungen und Promotionsmöglichkeiten im Bereich Musikvermittlung an deutschsprachigen Hochschulen und Universitäten 2021.; 2023
Entwicklungspsychologie des Talents. Potenziale erkennen, Förderung gestalten, Herausforderungen bewältigen
No full textHeye A, Olbertz F. Entwicklungspsychologie des Talents. Potenziale erkennen, Förderung gestalten, Herausforderungen bewältigen. In: Grabow M, Busch B, Krause-Benz M, eds. Talente entdecken – Begabung fördern. 15 Jahre Netzwerk Amadé . Mannheimer Manieren – Musik + Musikforschung. Vol 11. Hildesheim: Olms; 2022: 31-54
Time scales and mechanisms of uranium uptake in altered ocean crust; observations from the ~15 million year-old Site 1256 in the eastern equatorial Pacific
No full textThe alteration of ocean crust through hydrothermal seawater circulation facilitates chemical exchange between Earth’s surface and interior. Hydrothermal alteration leads to uranium (U) removal from seawater and net U uptake by the ocean crust, particularly during low temperature alteration that occurs on the vast ocean ridge flanks away from the spreading axes. Determining the timescales of U uptake and its associated 238U/235U signature has important implications for understanding U exchange processes during subduction and recycling into the mantle. Here we study the U systematics of ~15 million year-old ocean crust drilled at Site 1256 on the eastern flank of the East Pacific Rise. Analysis of cores from the upper ~1300 meters of intact ocean crust at this site, reveal large variability in U concentrations and 238U/235U ratios. Many of the samples from the upper ~600 meters of extrusive lavas have elevated U concentrations and 238U/235U ratios lower than seawater, consistent with mechanisms of U uptake under relatively oxidised conditions. Samples from the underlying sheeted dikes and gabbros show evidence for hydrothermal U mobilisation, but negligible net U uptake. In contrast, in the transition zone between the extrusive lavas and the sheeted dikes, samples revealed large U enrichments and high 238U/235U ratios above seawater. This is consistent with uptake of the reduced U+4 species under relatively reducing conditions from seawater-derived hydrothermal fluids. In addition, large secular disequilibrium in 234U/238U ratios from samples in the lava-dike transition and upper sheeted dikes give evidence for U mobility within the last ~1.5 million years, likely driven by deep channelled flow of seawater- derived hydrothermal fluids combined with preferential leaching of 234U from the rock matrix. Both the total estimated U uptake and mean 238U/235U at Site 1256 is lower than similar estimates from significantly older (>100 million years) altered ocean crusts at drill Sites 801 and 417/418. This shows the variable total U uptake and 238U/235U ratio in altered ocean crust over time, which needs to be taken into consideration when estimating global U budgets
Placement of an aortomonoiliac stent graft without femorofemoral revascularization in endovascular aneurysm repair: a case report
No full textIntroduction: Endovascular aortic repair, if technically feasible, is the treatment of choice for patients with a contained ruptured aortic aneurysm who are unfit for open surgery. Case presentation: We report the case of an 80-year-old Caucasian man who presented with an unusually configured, symptomatic infrarenal aortic aneurysm. His aneurysm showed an erosion of the fourth lumbar vertebra and a severely arteriosclerotic pelvic axis. A high thigh amputation of his right leg had been performed 15 months previously. On his right side, occlusion of his external iliac artery, common femoral artery, and deep femoral artery had occurred. His aneurysm was treated by a left-sided aortomonoiliac stent graft without femorofemoral revascularization, resulting in occlusions of both internal iliac arteries. No ischemic symptoms appeared, although perfusion of his right side was maintained only over epigastric collaterals. Conclusions: The placement of aortomonoiliac stent grafts for endovascular treatment of infrarenal aortic aneurysms without contralateral revascularization is a feasible treatment option in isolated cases. In this report, access problems and revascularization options in endovascular aneurysm repair are discussed
Cortically evoked motor responses in patients with Xp22.3-linked Kallmann's syndrome and in female gene carriers
No full textPatients with Kallmann's syndrome show hypothalamic hypogonadism, hyposmia, and congenital mirror movements. As a correlate, a defect of gonadotropic neuron migration into the brain was recently detected. Considering abnormal outgrowth of neurons also as a possible substrate underlying mirror movements, we studied 3 patients and 2 asymptomatic female gene carriers from a kindred with proven linkage to Xp22.3, using focal transcranial magnetic stimulation of motor cortex hand areas with a figure-eight coil. In all 3 affected brothers, bilateral responses could be evoked almost simultaneously in their thenar muscles (slight latency differences were statistically insignificant). In contrast, the mother and the maternal aunt showed only unilateral, normal thenar responses, even with maximum tolerable stimulator output and high signal amplification. Correspondingly, mirror movements were present in the patients, but not in the gene carriers. Bilaterality of cortically evoked hand muscle responses and mirror movements, therefore, behaved as X-chromosomal recessive traits. A likely cause might be a disorder of neuronal outgrowth in the motor system, particularly of inhibitory callosal fibers. For normal anatomical development of the motor system, one intact Xp22.3 gene seems necessary
The breakpoint identified in a balanced de novo translocation t(7;9)(p14.1;q131.3) disrupts the A-kinase (PRKA) anchor protein 2 gene (AKAP2) on chromosome 9 in a patient with Kallmann syndrome and bone anomalies.
No full textWe report the molecular characterization of a patient with Kallmann syndrome and bone anomalies bearing a balanced de novo translocation t(7;9)(p14.1;q31.3) which completely disrupts the A-kinase anchor protein 2 gene (AKAP2) on chromosome 9. In order to investigate the role of AKAP2 in the pathogenesis of the disease, we analyzed the expression of Akap2 in mouse embryos. The expression pattern was consistent with the phenotype observed and mAkap2 was actually found in the olfactory bulb and in the cartilagineous structures of the embryo. Since AKAP2 is supposed to bind and compartmentalize the PKA, we also analyzed the distribution and quantity of PKA in limpho-
blastoid cell lines of the patient compared with a control; these experiments did not demonstrate any differences between the cell lines. Furthermore a collection of 98 DNA samples from sporadic Kallmann patients was screened for mutations in this gene. The analysis revealed two different sequence variations observed in two patients but not in 200 control chromosomes: since they have been detected also in the unaffected mother of one of the two patients we can assume that they are rare polymorphisms, although we cannot exclude that they represent mutations with incomplete penetrance. Our findings suggest that the complex phenotype with Kallmann syndrome and bone anomalies observed in our patient could be the result of the interruption of the AKAP2 gene. However, a position effect mediated by the translocation could not be excluded. The screening of AKAP2 in other Kallmann patients will be necessary to elucidate its role in the pathogenesis of the disease
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