106 research outputs found
Making Peace in an Age of War: Emperor Ferdinand III (1608–1657)
No full textThis English-language translation of Mark Hengerer\u27s Kaiser Ferdinand III: 1608–1657 Eine Biographie is based on an analysis of the weekly reports sent by the papal nuncio’s office to the Vatican. These reports give detailed information about the daily whereabouts of the dynasty, courtiers, and foreign visitors, and they contain the gossip of the court in addition to weekly analysis of some political problems. This material enabled the author to report on daily life of the dynasty and to analyze the circumstances under which policy was made, which has led to a balance between the personality of Ferdinand III and the problems with which he dealt. In this biography, Hengerer provides answers to the question: Why did it take the emperor more than ten years to end a devastating war, the traumatizing effects of which on central Europe lasted into the twentieth century, particularly since there was no hope of victory against his foreign adversaries from the very moment he came into power?https://docs.lib.purdue.edu/purduepress_previews/1040/thumbnail.jp
Making Peace in an Age of War
No full textThis English-language translation of Mark Hengerer's Kaiser Ferdinand III: 1608–1657 Eine Biographie is based on an analysis of the weekly reports sent by the papal nuncio’s office to the Vatican. These reports give detailed information about the daily whereabouts of the dynasty, courtiers, and foreign visitors, and they contain the gossip of the court in addition to weekly analysis of some political problems. This material enabled the author to report on daily life of the dynasty and to analyze the circumstances under which policy was made, which has led to a balance between the personality of Ferdinand III and the problems with which he dealt. In this biography, Hengerer provides answers to the question: Why did it take the emperor more than ten years to end a devastating war, the traumatizing effects of which on central Europe lasted into the twentieth century, particularly since there was no hope of victory against his foreign adversaries from the very moment he came into power
Making Peace in an Age of War
No full textThis English-language translation of Mark Hengerer's Kaiser Ferdinand III: 1608–1657 Eine Biographie is based on an analysis of the weekly reports sent by the papal nuncio’s office to the Vatican. These reports give detailed information about the daily whereabouts of the dynasty, courtiers, and foreign visitors, and they contain the gossip of the court in addition to weekly analysis of some political problems. This material enabled the author to report on daily life of the dynasty and to analyze the circumstances under which policy was made, which has led to a balance between the personality of Ferdinand III and the problems with which he dealt. In this biography, Hengerer provides answers to the question: Why did it take the emperor more than ten years to end a devastating war, the traumatizing effects of which on central Europe lasted into the twentieth century, particularly since there was no hope of victory against his foreign adversaries from the very moment he came into power
Why comply?: risk and efficacy perceptions drive compliance in mass marketing scams
No full textUsing a mix-method design, we examined participants’ willingness to respond to mass marketing scams (MMS). In Experiment 1, we examined the effect of age (young versus older) and letter style (“hot” versus “cold”) on the intention to respond. The intention of responding was negatively associated with risk (p <.001) and having at least a high school education was positively associated with perception of benefits (b =.684, p <.001). In Experiment 2, we examined reward sensitivity on the intention to respond by manipulating reward amounts (low versus high) and the presence of an activation fee. The presence of an activation fee decreased intent to contact, but percentages remained high (25.75%). Analyses of qualitative data indicated that risk and benefit were both predicted by perceived self-efficacy. The results indicate that consumers’ beliefs about their ability to control the outcomes of future interactions affected how they behaved when provided with MMS materials.</p
Differential sialylation of serpin A1 in the early diagnosis of Parkinson's disease dementia.
No full textThe prevalence of Parkinson's disease (PD) increases with age. Up to 50% of PD show cognitive decline in terms of a mild cognitive impairment already in early stages that predict the development of dementia, which can occur in up to 80% of PD patients over the long term, called Parkinson's disease dementia (PDD). So far, diagnosis of PD/PDD is made according to clinical and neuropsychological examinations while laboratory data is only used for exclusion of other diseases. The aim of this study was the identification of possible biomarkers in cerebrospinal fluid (CSF) of PD, PDD and controls (CON) which predict the development of dementia in PD. For this, a proteomic approach optimized for CSF was performed using 18 clinically well characterized patients in a first step with subsequent validation using 84 patients. Here, we detected differentially sialylated isoforms of Serpin A1 as marker for differentiation of PD versus PDD in CSF. Performing 2D-immunoblots, all PDD patients could be identified correctly (sensitivity 100%). Ten out of 24 PD patients showed Serpin A1 isoforms in a similar pattern like PDD, indicating a specificity of 58% for the test-procedure. In control samples, no additional isoform was detected. On the basis of these results, we conclude that differentially sialylated products of Serpin A1 are an interesting biomarker to indicate the development of a dementia during the course of PD
Nasal Superior Versus Nasal Inferior Implantation of the XEN45 Gel Stent – One Year Results
No full textPurpose: To assess effectiveness of the XEN45 gel stent after nasal superior implantation compared to nasal inferior implantation.
Methods: Retrospektive analysis of 152 eyes with XEN45 gel stent implantation in the nasal superior quadrant (Group A, n=56) or in the nasal inferior quadrant (Group B, n=96).
Results: Mean IOP decreased from 33.6± 8.8 mmHg preoperatively to 14.6± 3.2 mmHg at Month 12 in Group A (p 0.05). Needling was required in 45% of eyes in Group A and in 27% of Group B (p=0.031; Fisher`s exact test). A second XEN45 gel stent was implanted in 4 eyes of Group A and 7 eyes of Group B. Hypotony (IOP ≤ 6 mmHg) was observed in 3 eyes of Group A and 4 eyes of Group B. All cases resolved spontanously.
Conclusion: Overall, the 1-year results of our retrospective analysis show that implantation of the XEN45 gel stents in the nasally inferior quadrant is as effective as implantation in the superior nasal quadrant and results in significantly reduced IOP and medication usage in glaucoma patients
Les auteurs
No full textFrancis B. Assaf université de Géorgie (États-Unis) Martine Boiteux École des hautes études en sciences sociales, Paris Leonardo Carvalho-Gonçalves université Paris I Panthéon-Sorbonne Michel Cassan université de Poitiers Juliusz A. Chrościcki université de Varsovie Luis Javier Cuesta Hernández université ibéro-américaine, México Sylvène Édouard université Jean Moulin-Lyon 3/UMR 5190 LARHRA Stéphane Haffemayer université de Caen Basse-Normandie Mark Hengerer université Louis-Maximilien (LMU),..
Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS/MND: report on the 142nd ENMC International Workshop
No full textA transgenic animal model for anterior horn cell loss was established in 1994. This model is based on the insertion of a high copy number of disease-causing human Cu/Zn SOD mutations into the intact mouse genome. It serves to establish hypotheses for the pathogenesis of anterior horn cell death, but also to test potential pharmacological approaches to therapy in human ALS. Today, more than 100 - published and unpublished - compounds have been tested in this animal model, a large part of them being reported as successful. However, it proved to be difficult to translate these therapeutic successes in the animal model into human trials. Also, a number of disease-modifying strategies were difficult to reproduce, even by the same group. On the other hand, the step from mice to men means a huge investment for the sponsors of clinical trials and the scientific community. Therefore, establishment of standard methods for drug testing in ALS models is mandatory. In this workshop, clinical and preclinical researchers established in the field of ALS/MND met in Holland in March 2006 in order to establish guidelines for the community for drug testing in mouse models
ChemInform Abstract: Design and Synthesis of a Biotinylated Dopamine Transporter Ligand for the Purification and Labeling of Dopaminergic Neurons.
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