1,721,029 research outputs found
Genetic variance in Vasopressin V1b Receptor and a locus associated with high vasopressin level in plasma are associated with body mass index and waist circumference.
No full textObjective: Recently, imbalance in the vasopressin (VP) system, measured as elevated levels of copeptin in plasma, the c-terminal part of the AVP pro-hormone, was linked to development of abdominal obesity. Now we aimed (1) to investigate if genetic variation of the human AVP receptor 1b gene (AVPR1B) is associated with measures of obesity, (2) to identify loci associated with elevated copeptin levels using metabochip analysis and (3) to test if any copeptin-associated loci is (are?) associated with measures of obesity.Design and method: Malmö Diet and Cancer study (MDC) is a population-based prospective cohort examined 1991-1994. (1) 4 tag SNPs (rs35810727, rs28373064, rs35439639, rs35608965) of AVPR1B were genotyped in the cardiovascular cohort (n=6103) of MDC (MDC-CC),associated with measures of obesity and significant SNPs were replicated in another 24344 MDC individuals (MDC replication cohort). (2) Copeptin was measured in MDC-CC and the metabochip was genotyped in 2143 MDC-CC participants. Nineteen SNPs associating with copeptin level at p-value<0.00038, were selected for replication of copeptin association in the remaining of MDC-CC (n=3960). (3) Copeptin-associated SNPs were tested for association with measures of obesity. Results: In MDC-CC, after age and sex adjustment, the major allele of rs35810727 was associated with BMI (P=0.02) and waist (P=0.02). The association with BMI was replicated in the MDC replication cohort (P<0.001), whereas that with waist remained only borderline significant (P=0.06). Out of 19 copeptin associated metabochip SNPs, the major allele of rs6835657 was associated with high levels of copeptin in both the metabochip-genotyped subset of MDC-CC (p=0.0002) and in the remaining part of MDC-CC (P=0.005). Furthermore, the rs6835657 allele associated with high copeptin was associated with high waist (P=0.03) in the entire MDC-CC.Conclusions: Genetic variants of a locus associated with elevated VP (copeptin) (rs6835657), as well as genetic variance of the AVPR1B, can contribute to overweight. Our data points at a causal relationship between disturbance of the pharmacologically modifiable VP system and body weight regulatio
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Prediction of blood pressure change over time and incidence of hypertension by a genetic risk score in Swedes.
No full textObjective: Recent Genome Wide association studies pinpointed different single nucleotide polymorphisms (SNPs) consistently associated with blood pressure (BP) and hypertension prevalence. Anyhow, scanty data exist about SNPs predicting BP variation over time and incidence of hypertension. The aim of our study was to confirm the association of a genetic risk score (GRS), based on 29 independent SNPs, with cross sectional BP and hypertension prevalence and to challenge its prediction about BP change over time and hypertension incidence in middle-aged Swedes participating in a prospective survey in Malmö (Sweden).
Design and Methods: Twenty-nine SNPs were genotyped in 18,240 participants included in the “Malmö Preventive project”. The same subjects were investigated at baseline and over a period of an average of 23 years of follow-up. The GRS was calculated by summing the number of risk alleles across the panel of SNPs tested (0, 1, and 2 were attributed according to the number of risk alleles present).
Results: The GRS was associated with higher systolic and diastolic BP values both at baseline and at reinvestigation and with increase prevalence of hypertension (p<1.0E-11 and lower for all). The GRS was positively associated with change in BP and the incidence of hypertension, independently from “traditional factors” (p<1.0E-4 and lower for all). The relative weight of the GRS [1st vs. 4th quartile OR (95%CI) 1.298 (1.161-1.452) p<1.0E-5] was lower compared to other well known predictors such as obesity and positive family history (PFH) but almost similar in magnitude as compared with diabetes mellitus, and higher with respect to chronic kidney disease and heart rate.
Conclusions: Our data show that a GRS can help predicting BP variation and incidence of hypertension over time. The lower magnitude of the GRS, despite the well-known high heritability of all BP related traits, suggests that either many common SNPs influencing BP remain to be discovered or that rarer variants with higher effect on BP have a major impact also at population level
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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