1,496 research outputs found
Lauren Gunderson (b.1982)
No full textThis essay situates American playwright Lauren Gunderson (b.1982) in the present theatrical scenario. Three times the most produced playwrights in the US (in seasons 2017–2018, 2019–2020, and 2022–2023), Gunderson provides guidelines to understand her work: from her writing of lighter pieces and the more politically committed ones to her revision of classic texts and her original historical dramas. Gunderson presents herself as a feminist playwright who relocates women in their place in history while writing plays for both men and women. This essay also discusses Gunderson’s role as a drama and theatre theorist by paying close attention to her 2015 speech, “Survival of the Storied: Why Science Needs Art and Art Needs Science.” Here, Gunderson argues the need for and value of featuring the stories of women scientists on the stage and reminds us of the inherent power of good plays to move audiences into action in order to make a better world—a common goal shared by Science and Ar
A-1179: Hyrum, Utah, Esther Gunderson residence. Lot 5-6 Block 8 Plat B. Built 1905
No full textA-1179: Hyrum, Utah, Esther Gunderson residence. Lot 5-6 Block 8 Plat B. Built 190
North American Economic Integration and Globalization
No full textMorley Gunderson presents an overview of issues related to North American economic integration and globalization. He provides a particularly balanced perspective, a rarity in this area of highly charged, ideology-driven and emotional debate. He first notes that economic integration has both a deepening and widening dimension and enumerates the various aspects of these two dimensions in the context of North American integration, noting that in practice the different dimensions complement one another in a self-reinforcing fashion. He also points out that deeper and wider economic integration can foster internal consolidation since this integration is generally regarded as a precondition for external competitiveness. Gunderson pays particular attention to the issue of policy integration. He argues that the emerging competitive pressures on the North from low-cost, less regulated jurisdictions in the South is the most important consequence of trade liberalization and globalization, although there is still insufficient evidence of harmonization leading to the lowest common denominator. The policy-making process is now subject to the forces of competition that apply to business and labour. He argues that the laws and regulations that will be under the most pressure will be those that are the most inefficient, that is those that protect interest group rents and impose costs without commensurate benefits. Gunderson notes that integration represents a threat to distributional or equity-oriented policies that do not have positive feedback effects on efficiency even when the population considers such policies highly desirable. Raising taxes to finance these policies may not be the solution if mobile factors of production consequently flee to lower-tax jurisdictions. He documents the wide range of policy responses to the potential policy vacuum created by globalization and integration, including the NAFTA labour side agreement, the inclusion of social clauses in trade agreements, corporate codes of conduct, social labelling, and consumer boycotts, transnational efforts amongst unions, social groups and NGOs and union-to-union cooperation. But he finds that effectiveness of these responses to date is moot. Gunderson raises the issue of whether the more circumscribed role of governments and greater role of market forces will in fact benefit the most disadvantaged. He notes that so far this has not been the case, although whether this negative trend will continue is an open question. He concludes by cautioning that the long-run sustainability of integration depends on the equitable sharing of the efficiency gains arising from this process.Canada, North America, NAFTA, Integration, Border Effects, Policy Integration, Competitiveness
Nature, sociology, and the Frankfurt School
No full text"Through a systematic analysis of the works of Max Horkheimer, Theodor W. Adorno, Herbert Marcuse, and Erich Fromm using historical methods, [the author] documents how early critical theory can conceptually and theoretically inform sociological examinations of human-nature relations. Currently, the first-generation Frankfurt School's work is largely absent from and criticized in environmental sociology. [Gunderson] addresses this gap in the literature through a series of articles. One line of analysis establishes how the theories of Horkheimer, Adorno, and Marcuse are applicable to central topics and debates in environmental sociology. A second line of analysis examines how the Frankfurt School's explanatory and normative theories of human-animal relations can inform sociological animal studies. The third line examines the place of nature in Fromm's social psychology and sociology, focusing on his personality theory's notion of biophilia.--Abstract.Thesis (Ph. D.)--Michigan State University. Sociology, 2014Includes bibliographical references (pages 128-147
Genotype calling in tetraploid species from bi-allelic marker data using mixture models
No full textAbstract Background Automated genotype calling in tetraploid species was until recently not possible, which hampered genetic analysis. Modern genotyping assays often produce two signals, one for each allele of a bi-allelic marker. While ample software is available to obtain genotypes (homozygous for either allele, or heterozygous) for diploid species from these signals, such software is not available for tetraploid species which may be scored as five alternative genotypes (aaaa, baaa, bbaa, bbba and bbbb; nulliplex to quadruplex). Results We present a novel algorithm, implemented in the R package fitTetra, to assign genotypes for bi-allelic markers to tetraploid samples from genotyping assays that produce intensity signals for both alleles. The algorithm is based on the fitting of several mixture models with five components, one for each of the five possible genotypes. The models have different numbers of parameters specifying the relation between the five component means, and some of them impose a constraint on the mixing proportions to conform to Hardy-Weinberg equilibrium (HWE) ratios. The software rejects markers that do not allow a reliable genotyping for the majority of the samples, and it assigns a missing score to samples that cannot be scored into one of the five possible genotypes with sufficient confidence. Conclusions We have validated the software with data of a collection of 224 potato varieties assayed with an Illumina GoldenGate™ 384 SNP array and shown that all SNPs with informative ratio distributions are fitted. Almost all fitted models appear to be correct based on visual inspection and comparison with diploid samples. When the collection of potato varieties is analyzed as if it were a population, almost all markers seem to be in Hardy-Weinberg equilibrium. The R package fitTetra is freely available under the GNU Public License from http://www.plantbreeding.wur.nl/UK/software_fitTetra.html and as Additional files with this article.</p
The Lemming Vole, \u3ci\u3eSynaptomys borealis\u3c/i\u3e, in Northern Minnesota
No full textLemming voles of the subgenus Mictomys have never been recorded from north-central United States, although they might be expected to occur there judging from records of the species Synaptomys (Mictomys) borealis from southern Manitoba. Recently, examination of specimens in the collection of the Minnesota Museum of Natural History reveals that Synaptomys borealis does occur in north-central United States for we have found the following specimens referable to that species: one immature female (No. 951, MMNH) from Williams, Lake of the Woods County, Minnesota, collected by Gustav Swanson, August 5, 1932; one adult male (No. 2552, MMNH) from Warroad, Roseau County, Minnesota, collected by H. L. Gunderson and B. J. Hayward, July 27,1948
Clinical Trial Simulation in Diabetic Retinopathy: Insights from Patients and Site Staff
No full textIntroduction: High patient burdens from diabetic retinopathy (DR)-associated vision loss and intravitreal therapy (IVT) support patient experience inclusion in DR trial designs. This trial simulation characterized patient and site staff opinions to improve future nonproliferative DR (NPDR) trial designs. Methods: Between March 27 and May 31, 2023, survey data were collected from trial simulation participants. After a preread and trial design animation, study features were simulated followed by a 75-90-min web-assisted telephone interview. Patients with NPDR and trial site staff from the United States, United Kingdom, and Germany were included. The likelihood of patient participation and the challenges faced by site staff in conducting the simulated clinical trial at their study site were assessed using a 1-7 scale. Outcomes were evaluated via thematic analysis and descriptive statistics. Results: Twenty-two patients aged 36-55 years and mostly female (59.1%), and 16 site staff were interviewed. Mean NPDR duration was 9.3 years; most patients (81.8%) had never participated in a clinical trial. Although eligibility criteria resembled other trials, site staff indicated that restrictive exclusion criteria of the trial simulation could limit recruitment and that endpoints did not match patients' goals, which mainly focused on saving vision. The proposed 4-5-h on-site visits and 72-week trial length were considered "too long" by 45.5% and 50.0% of patients, respectively. For the 1:2 sham or active treatment allocation ratio, responses were 40.9% neutral, 36.4% positive, and 22.7% negative. Some patients misunderstood that sham injections imitate actual injections, expressing concerns about adverse events. Patients reported IVT-related anxieties, particularly IVT-inexperienced patients. Mean patient trial participation interest score was 4.9/7; 62.5% of site staff were interested in conducting the trial. Some proposed adaptations were implemented in the trial protocol (e.g., offering patient/caregiver transportation). Conclusions: Insights gained from respondent feedback in this simulation may inform future DR clinical trial design, potentially enhancing recruitment rates and patient experience
Apprendi, Blakely and Federalism
No full textThe Clark Y. Gunderson Lecture is a memorial to a man who devoted his life to legal education and spent thirty years teaching at the Law School. It is supported by a trust fund in the University of South Dakota Law School Foundation established principally by Colonel Gunderson\u27s family. Professor Rutledge delivered the 2004 Gunderson Lecture at the Law Review\u27s Symposium on Sentencing and Punishment, which took place at the Law School on November 5, 2004. What follows is an adapted version of Professor Rutledge\u27s lecture
Changing U1A levels regulate expression of immunoglobulin M and the transcriptional repressor Zhx1 during B cell differentiation
No full textDuring B cell differentiation U1A plays an important role in regulating the expression of the secretory poly(A) site by inhibiting both cleavage and polyadenylation. Previous work demonstrated that the inhibitory effect of U1A is alleviated in differentiated cells, which express the secretory poly(A) site, however, the mechanism underneath was unveiled. Using B cell lines representing different stages of B cell differentiation, here we show that U1A levels are reduced in differentiated cells. Undifferentiated B cells have more total U1A than differentiated cells and a greater proportion of U1A is not associated with the U1snRNP. We demonstrate that this non-snRNP associated U1A is available to inhibit poly(A) addition at the secretory poly(A) site. In addition, endogenous non-snRNP associated U1A--immunopurified from the different cell lines--inhibited poly(A) polymerase activity proportional to U1A recovered, suggesting that available U1A level alone is responsible for changes in its inhibitory effect at the secretory IgM poly(A) site.
It is known that U1A can regulate the expression of its own and IgM gene. Here we report that during mouse B cell differentiation U1A also regulates the expression of the transcriptional repressor, Zhx-1 (zinc fingers and homeoboxes 1), via alternative poly(A) site selection. Using affymetrix microarray analysis combined with RT-PCR techniques, we demonstrate that U1A binds to Zhx-1 mRNA in vivo. We show that the levels of Zhx-1 proteins and mRNA are negatively correlated with U1A levels in B cells and overexpression of U1A in HeLa cells significantly inhibits the expression of Zhx-1. Our in vitro and in vivo assays show that U1A regulates the expression of the upstream poly (A) site of Zhx-1 by binding to the five non-consensus motifs around the poly(A) site and inhibiting both poly(A) addition and cleavage. When the upstream poly(A) site of Zhx-1 is inhibited in mature B cells, the usage of the downstream poly(A) site of Zhx-1 results in the inclusion of ARE elements, which destabilize the mRNA transcript. As a result, less Zhx-1 RNA and protein are produced in mature B cells. We proposed one model about how U1A and ARE coordinately regulate the expression of Zhx-1 during B cell differentiation.Ph.D.Includes bibliographical references (p. 124-146)
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