854 research outputs found
Random matrices and random boxes
No full textThis thesis concerns two questions on random structures: the semi-circular law for adjacency matrix of regular random graph and the piercing number for random boxes. Random matrices: We proved in full generality the semi-circular law for random d-regular graph model in the case d tends to infinity as n does. Our result complements the McKay law [19], which applied for the case d is an absolute constant. Random boxes. Take n random boxes with axis-parallel edges inside the unit cube [0; 1][superscript]d, the piercing number is the minimum number of points needed to pierce all boxes. Using hypergraph setting, we was able to prove a near sharp estimation for the piercing number. This thesis is based on two papers by the author [31] and [30] (joint work with Van Vu and Ke Wang).Ph.D.Includes bibliographical referencesIncludes vitaby Linh V. Tra
Noncytotoxic 16,23-epoxycucurbitacin-type triterpenoids from Elaeocarpus hainanensis
No full textPhytochemical investigation of methanol extract from Elaeocarpus hainanensis Oliv. leaves and twigs led to the isolation and structural determination of three 16,23-epoxycucurbitacin-type triterpenoids, including a new hydroperoxide, 16α,23α-epoxy-3β,20β-dihydroxy-24α-hydroperoxy-10αH,23βH-cucurbit-5,25-dien-11-one (elahainencin A, 1), and two known analogs (2 and 3). Their chemical structures were determined by the spectroscopic analyses, including 1 D-, 2 D NMR and HR ESI MS spectra. Compound 1 represents a cucurbitacin derivative incorporating a hydroperoxide. In addition, these isolated compounds have been found to be noncytotoxic when tested in vitro against five human cancer cell lines (A549, T24, 8505, Huh-7 and SNU-1) by using the SRB method
Reactivity of Rhodium(II) amido/Rhodium(I) aminyl complexes
No full textReaction of the Rh(II) dimer [LRh]2(μ-Br)2 (L = ([2,6-Me2C6H3NCMe]2CH) with the bulky amide LiNH(2,6-iPr2C6H3) leads to a monomeric Rh(II) amide with a T-shape N3Rh arrangement and a pronounced agostic interaction. Reaction with the less bulky LiNH(2,6-Me2C6H3) results in benzylic C-H activation to a binuclear complex with a unique aza-xylylene bridging mode. With LiNHC6H5 we observe initial formation of [LRh]2(μ-NHPh)2 followed by N,C2′ coupling of two anilines. These reactions can be explained based on aminyl radical character of the Rh(II) amides (supported by EPR evidence) and/or involvement of nitrene intermediates
D. melanogaster predictions
No full textAbout this dataset: These are the most reliable 100,000 PPI predictions for D. melanogaster. It is a CSV file.Motivation: Protein-protein interactions (PPIs) play a key role in many cellular processes. Most annotations of PPIs mix experimental and computational data. The mix optimizes coverage, but obfuscates the annotation origin. Some resources excel at focusing on reliable experimental data. Here, we focused on new pairs of interacting proteins for several model organisms based solely on sequence-based prediction methods. Results: We extracted reliable experimental data about which proteins interact (binary) for eight diverse model organisms from public databases, namely from Escherichia coli, Schizosaccharomyces pombe, Plasmodium falciparum, Drosophila melanogaster, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Arabidopsis thaliana, and for the previously used Homo sapiens and Saccharomyces cerevisiae. Those data were the base to develop a PPI prediction method for each model organism. The method used evolutionary information through a profile-kernel Support Vector Machine (SVM). With the resulting eight models, we predicted all possible protein pairs in each organism and made the top predictions available through a web application. Almost all of the PPIs made available were predicted between proteins that have not been observed in any interaction, in particular for less well-studied organisms. Thus, our work complements existing resources and is particularly helpful for designing experiments because of its uniqueness. Experimental annotations and computational predictions are strongly influenced by the fact that some proteins have many partners and others few. To optimize machine learning, the newly methods explicitly ignored such a network-structure. This might be another strength of our approach. The database interface representing our results is accessible from https://rostlab.org/services/ppipair/.Please cite us when you are using this data:@article{tran2018profppidb,
title={ProfPPIdb: pairs of physical protein-protein interactions predicted for entire proteomes},
author={Tran, Linh and Hamp, Tobias and Rost, Burkhard},
journal={bioRxiv},
pages={332510},
year={2018},
publisher={Cold Spring Harbor Laboratory}
}</pre
Phenolic Acid Analogues from Balanophora laxiflora Inhibit Proliferation of In Vitro Acute Myeloid Leukemia Cells
No full textFour phenolic analogues isolated from Balanophora laxiflora; methyl gallate (1, MG), 4-hydroxy-3-methoxycinnamaldehyde (2), 3-methoxycinnamic acid (3), and methyl caffeate (4, MC) were shown to have antiproliferative activity on acute myeloid leukemia (OCI-AML3) cells due to impaired cell cycle progression. Three of these compounds (1, 3, and 4) caused increased apoptosis and decreased proliferationin cells. Interestingly, MC (compound 4) significantly decreased the percentage of cells in S phase and G2/M phase, and significantly increased apoptosis in cells at low concentrations. Treatment with these compounds increased Fas ligand production and caspase-8/3, but not caspase-9-dependent, apoptosis. These results suggest that dosing with these compounds decreases proliferation and increases apoptosis in cell lines derived from hematological cancers
Fig. 11 in Tylopus Millipedes In Vietnam (Diplopoda: Polydesmida: Paradoxosomatidae: Sulciferini), With Descriptions Of Five New Species
No full textFig. 11. Tylopus hilaris (Attems, 1937) from Ngoc Linh Mt.: hypoproct, ventral view (A); sternite 5, posterioventral view (B); leg 9 (C); right gonopod, mesal view (D) and lateral view (E). Scale bars = 1 mm.Published as part of Nguyen, Anh D., 2012, Tylopus Millipedes In Vietnam (Diplopoda: Polydesmida: Paradoxosomatidae: Sulciferini), With Descriptions Of Five New Species, pp. 289-311 in Raffles Bulletin of Zoology 60 (2) on page 304, DOI: 10.5281/zenodo.534727
Flavonoid from the aerial parts of Cardiospermum halicacabum L
No full textThe first chemical investigation on Cardiospermum halicacabum L. growing in Vietnam led to the isolation and structural determination of nine flavonoid compounds, including quercetin 3-O-β-D-glucoside (1), quercetin 3-O-α-L-rhamnoside (2), quercetin (3), kaempferol 3-O-α-L-rhamnoside (4), kaempferol (5), apigenin 7-O-β-D-glucuronide butyl ester (6), apigenin 7-O-β-D-glucuronide methyl ester (7), apigenin (8), and luteolin (9). Their structures were established by using HR ESI MS, 1D and 2D NMR spectroscopic methods and comparison with those of the related published data. With exceptions to flavonoids 3 and 8, the rest seven compounds (1-2, 4-7, and 9) were found for the first time from this plant. Notably, two rare flavonoids (6 and 7) have not yet been reported from the Sapindaceae family before
Immunomodulatory and cytotoxic effects of bergenin and cinchonain Ia isolated from Peltophorum pterocarpum
No full textThis paper reports for the first time the immunomodulatory and cytotoxic effects of two previously isolated compounds from the stem of Peltophorum pterocarpum and characterized as bergenin (1) and cinchonain Ia (2). The immunomodulatory capacity of these two compounds was assessed based on their ability to inhibit IL-2 release from RAW264.7 cells. The results demonstrated that cinchonain Ia (2) possesses distinctly immunomodulatory effects in vitro since this compound strongly inhibited IL-2 cytokine level (at concentrations of 4.0 and 0.8 μg/mL) (P<0.01 and P<0.05), while it was increased up to 8.84 time at the 100 μg/mL concentration. Additionally, compound 2 showed a weak cytotoxic effect against 5 human cancer cells (A549, Huh-7, T24, 8505, and SNU-1) with the IC50 values between 39.19 g/mL and 60.44 μg/mL
Emergency delivery of Vasopressin from an implantable MEMS rapid drug delivery device
No full textThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2009.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student submitted PDF version of thesis.Includes bibliographical references.An implantable rapid drug delivery device based on micro-electro-mechanical systems (MEMS) technology was designed, fabricated and validated for the in vivo rapid delivery of vasopressin in a rabbit model. In vitro characterization of device performance found the device capable of reliably and reproducibly delivering 85% of its loaded drug solution. A comparison of intraperitoneal and subcutaneous injections of vasopressin in rabbits was performed to determine the implantation location for the device. Both routes of delivery were found to be viable implantation locations, and the less invasive subcutaneous site was chosen. Vasopressin was released from the subcutaneously implanted device in anesthetized rabbits and found to exert a measurable effect on blood pressure. The bioavailability of vasopressin delivered from the device was found to be 6.2% after one hour. Proof-of-concept experiments were also conducted to address long-term stability of drugs in the implanted device and wireless activation of the device. These experiments defined areas of future research for improvement of the device.by Hong Linh Ho Duc.Ph.D
Processing of extremely high resolution LiDAR and RGB data: outcome of the 2015 IEEE GRSS data fusion contest—Part B: 3-D Contest
No full textIn this paper, we report the outcomes of the 2015 data fusion contest organized by the Image Analysis and Data Fusion Technical Committee (IADF TC) of the IEEE Geoscience and Remote Sensing Society. As for previous years, the IADF TC organized a data fusion contest aiming at fostering new ideas and solutions for multisource studies. The 2015 edition of the contest proposed a multiresolution and multisensorial challenge involving extremely high resolution RGB images (with a ground sample distance of 5 cm) and a 3-D light detection and ranging point cloud (with a point cloud density of approximatively 65 pts/m2 ). The competition was framed in two parallel tracks, considering 2-D and 3-D products, respectively. In this Part B, we report the results obtained by the winners of the 3-D contest, which explored challenging tasks of road extraction and ISO containers identification, respectively. The 2-D part of the contest and a detailed presentation of the dataset are discussed in Part A
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