25,173 research outputs found
Personal Papers (MS 80-0002)
No full textLetter from J. Earle Freeman of the D. B. McDaniel Cadillac Co. to Daniel W. Kempner quoting him a price for the repairs he wants done to his car
Nezara similis Freeman 1940
No full textNezara similis Freeman, 1940 (Fig. 1 D, 5, 6A–B, 7 D, 8 D, 9 D, 11 A–B, 16 D) Nezara similis Freeman, 1940: 368; Linnavouri, 1982: 138; Azim & Shafee, 1978: 507 Nezara similis var. flavolineata Freeman, 1940: 369 Diagnosis. Thorax: ostiolar ruga auriculate, inconspicuous (Fig. 3 E). Abdomen: black maculae of urosternites reduced or absent; median spine of III abdominal segment long, reaching anterior margin of posterior coxae. Male: ventral rim of pygophore with brims restricted to posterolateral angles, abruptly ending (Fig. 8 D), shared with N. viridula, N. antennata and N. yunnana; paramere trilobate, two lobes with pointed apex, median lobe scarcely observed in posterior view. Female: posterior margins of gonocoxites 8 straight; basal half of laterotergites 9 concave (Fig. 16 D). Material examined: Nezara similis Freeman, 1940 Holotype (♂ — BMNH) with labels: a) by beating b) MT CAMEROON Musake 6,350ft 13.I. 1932 M. Steele B.M. 1934 - 240 c) Type d) Nezara similis Freem. Nezara similis var. flavolineata Freeman, 1940 (♀ BMNH) MT CAMEROON Musake 6,350ft 13.I. 1932 M. Steele B.M. 1934 - 240 Type. Paratypes: CAMEROON: Mt. Cameroon, Musake 5,400ft, 28.I. 1932 M. Steele B.M. 1934 - 240 (♂ — BMNH); Mt. Cameroon, Musake, 6,350ft, 13.I. 1932 M. Steele B.M. 1934 - 240 (♀ BMNH).Published as part of Ferrari, Augusto, Schwertner, Cristiano Feldens & Grazia, Jocelia, 2010, Review, cladistic analysis and biogeography of Nezara Amyot & Serville (Hemiptera: Pentatomidae), pp. 1-41 in Zootaxa 2424 on pages 20-21, DOI: doi:10.11646/zootaxa.2424.1.1, http://zenodo.org/record/19455
Depolarization and decreased surface expression of K+ channels contribute to NSAID-inhibition of intestinal restitution
No full textNon-steroidal anti-inflammatory drugs (NSAIDs) contribute to gastrointestinal ulcer formation by inhibiting epithelial cell migration and mucosal restitution; however, the drug-affected signaling pathways are poorly defined. We investigated whether NSAID inhibition of intestinal epithelial migration is associated with depletion of intracellular polyamines, depolarization of membrane potential (Em) and altered surface expression of K+ channels. Epithelial cell migration in response to the wounding of confluent IEC-6 and IEC-Cdx2 monolayers was reduced by indomethacin (100μM), phenylbutazone (100μM) and NS-398 (100μM) but not by SC-560 (1μM). NSAID-inhibition of intestinal cell migration was not associated with depletion of intracellular polyamines. Treatment of IEC-6 and IEC-Cdx2 cells with indomethacin, phenylbutazone and NS-398 induced significant depolarization of Em, whereas treatment with SC-560 had no effect on Em. The Em of IEC-Cdx2 cells was: −38.5±1.8mV under control conditions; −35.9±1.6mV after treatment with SC-560; −18.8±1.2mV after treatment with indomethacin; and −23.7±1.4mV after treatment with NS-398. Whereas SC-560 had no significant effects on the total cellular expression of Kv1.4 channel protein, indomethacin and NS-398 decreased not only the total cellular expression of Kv1.4, but also the cell surface expression of both Kv1.4 and Kv1.6 channel subunits in IEC-Cdx2. Both Kv1.4 and Kv1.6 channel proteins were immunoprecipitated by Kv1.4 antibody from IEC-Cdx2 lysates, indicating that these subunits co-assemble to form heteromeric Kv channels. These results suggest that NSAID inhibition of epithelial cell migration is independent of polyamine-depletion, and is associated with depolarization of Em and decreased surface expression of heteromeric Kv1 channels.ID: S0006295207001931; M3: Article; Accession Number: S0006295207001931; Author: L.C. Freeman (b); Author: D.F. Narvaez (a); Author: A. McCoy (a); Author: F.B. von Stein (c); Author: S. Young (b); Author: K. Silver (a); Author: S. Ganta (b); Author: D. Koch (b); Author: R. Hunter (b); Author: R.F. Gilmour (c); Author: J.D. Lillich (a, ⁎); Affiliation: Department of Clinical Sciences, Kansas State University, Manhattan, KS 66506, United States; Affiliation: Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, United States; Affiliation: Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, United States; Keyword: Non-steroidal anti-inflammatory drugs; Keyword: Intestinal epithelial cells; Keyword: Membrane potential; Keyword: Potassium channels; Number of Pages: 12; Language: English;Source type: Electronic(1)http://search.ebscohost.com/login.aspx?direct=true&db=edselp&AN=S0006295207001931&site=eds-live&scope=sit
Multivariable norm optimal iterative learning control with auxiliary optimization
No full textThe paper describes a substantial extension of Norm Optimal Iterative Learning Control (NOILC) that permits tracking of a class of finite dimensional reference signals whilst simultaneously converging to the solution of a constrained quadratic optimization problem. The theory is presented in a general functional analytical framework using operators between chosen real Hilbert spaces. This is applied to solve problems in continuous time where tracking is only required at selected intermediate points of the time interval but, simultaneously, the solution is required to minimize a specified quadratic objective function of the input signals and chosen auxiliary (state) variables. Applications to the discrete time case, including the case of multi-rate sampling, are also summarized. The algorithms are motivated by practical need and provide a methodology for reducing undesirable effects such as payload spillage, vibration tendencies and actuator wear whilst maintaining the desired tracking accuracy necessary for task completion. Solutions in terms of NOILC methodologies involving both feedforward and feedback components offer the possibilities of greater robustness than purely feedforward actions. Robustness of the feedforward implementation is discussed and the work is illustrated by experimental results from a robotic manipulator
Who Escapes? The Relation of Church-Going & Other Background Factors to the Socio-Economic Performance of Blk. Male Yths. from Inner-City Pvrty Tracts
No full textUsing data from the NBER survey of Inner City youth and the National longitudinal survey of young men this paper examines the effect of church-going and other aspects of the background of youth their allocation of time, socially deviant behavior, and labor force behavior. 1)Church-going is associated with substantial differences in the behavior of youths, and thus in their chances to 'escape' from innercity poverty. It affects allocation of time, school-going, work activity, and the frequency of socially deviant activity.2)The diverse background factors examined in this study have different effects on various outcomes. Their differential effects suggest true causal impacts, with for example, the proportion of a youth's family working having positive effects on his labor market activity but not on other activities. 3) In addition to church going, the background factors that most influence'who escapes' are whether other members of the family work and whether the family is on welfare.4)The allocation of time and activities by youth is significantly influenced by market opportunities (or perceptions thereof). Those youths who believe it is easy to find a job are more likely to engage in socially productive activities than others. Youths who see many opportunities to make money illegally are less likely to engage in socially productive activities than other youths.
National Park and access thereto
No full textMap of Royal National Park and Botany Bay showing the Port Hacking and Georges RiverRelief shown by hachures and spot heightsIn upper left margin: No. of Lith. D. 88-11Compiled and drawn by P. B. James, Metropolitan & Coast District Survey Office, Sydney ; W. Freeman, Chief Draftsman ; J. W. Deering, District Surveyo
An assessment of the potential for intradiscal electrothermal therapy (IDET) to denervate posterior annular lesions
No full textB. J. C. Freeman, R. M. Walters, R. J. Moore, B. Vernon-Roberts, R. D. Frase
The effects of reducing worry in patients with persecutory delusions: study protocol for a randomized controlled trial
No full textBACKGROUND: Our approach to advancing the treatment of psychosis is to focus on key single symptoms and develop interventions that target the mechanisms that maintain them. In our theoretical research we have found worry to be an important factor in the development and maintenance of persecutory delusions. Worry brings implausible ideas to mind, keeps them there, and makes the experience distressing. Therefore the aim of the trial is to test the clinical efficacy of a cognitive-behavioral intervention for worry for patients with persecutory delusions and determine how the worry treatment might reduce delusions.METHODS: An explanatory randomized controlled trial - called the Worry Intervention Trial (WIT) - with 150 patients with persecutory delusions will be carried out. Patients will be randomized to the worry intervention in addition to standard care or to standard care. Randomization will be carried out independently, assessments carried out single-blind, and therapy competence and adherence monitored. The study population will be individuals with persecutory delusions and worry in the context of a schizophrenia spectrum diagnosis. They will not have responded adequately to previous treatment. The intervention is a six-session cognitive-behavioral treatment provided over eight weeks. The control condition will be treatment as usual, which is typically antipsychotic medication and regular appointments. The principal hypotheses are that a worry intervention will reduce levels of worry and that it will also reduce the persecutory delusions. Assessments will be carried out at 0 weeks (baseline), 8 weeks (post treatment) and 24 weeks (follow-up). The statistical analysis strategy will follow the intention-to-treat principle and involve the use of linear mixed models to evaluate and estimate the relevant between- and within-subjects effects (allowing for the possibility of missing data). Both traditional regression and newer instrumental variables analyses will examine mediation. The trial is funded by the UK Medical Research Council (MRC)/NHS National Institute of Health Research (NIHR) Efficacy and Mechanism Evaluation (EME) Programme.DISCUSSION: This will be the first large randomized controlled trial specifically focused upon persecutory delusions. The project will produce a brief, easily administered intervention that can be readily used in mental health services.Trial registration Current Controlled Trials ISRCTN23197625
Measurement of the ratios of branching fractions B(B-s(0)-> D-s(-)pi(+))/B(B-0 -> D-pi(+)) and B(B+->(D)over-bar(0)pi(+))/B(B-0 -> D-pi(+))
No full textWe report an observation of the decay B-s(0)-> D-s(-)pi(+) in p (p) over bar collisions at root s = 1.96 TeV using 115 pb(-1) of data collected by the CDF II detector at the Fermilab Tevatron. We observe 83 +/- 11(stat) B-s(0)-> D-s(-)pi(+) candidates, representing a large increase in statistics over previous measurements and the first observation of this decay at a p (p) over bar collider. We present the first measurement of the relative branching fraction B(B-s(0)-> D-s(-)pi(+))/B(B-0 -> D-pi(+))=1.32 +/- 0.18(stat)+/- 0.38(syst). We also measure B(B+->(D) over bar (0)pi(+))/B(B-0 -> D-pi(+))=1.97 +/- 0.10(stat)+/- 0.21(syst), which is consistent with previous measurements
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