1,198 research outputs found
La Spagna di Rajoy
No full textA un anno dalle elezioni che il 20 novembre 2011 hanno portato al governo il Partito popolare di Mariano Rajoy, una ricerca ideata e coordinata da Bonnie N. Field e Alfonso Botti sfocia in un volume che offre una ricostruzione della seconda legislatura di Rodríguez Zapatero (2008-2011), del tramonto della sua stella e della prima fase della nuova stagione politica.
Alcuni tra i migliori specialisti della storia e delle dinamiche socio-politiche della Spagna contemporanea di vari paesi e discipline (politologi, storici, sociologi e studiosi di economia politica) offrono un ventaglio di analisi esaurienti sull’attività dei partiti, le dinamiche parlamentari, i risultati elettorali, gli sviluppi delle politiche territoriali, la situazione sociale, economica e del mercato del lavoro, la condizione giovanile, l’atteggiamento della Chiesa e sui progressi dell’eguaglianza de genere. Ne esce una visione approfondita della più recente storia del paese iberico, utile a comprendere l’evoluzione politica spagnola ed europea
Variability and functional role of chromosomal sequences in 16SrI-B subgroup phytoplasmas including aster yellows and related strains
No full textAims: Partial genetic characterization of several chromosomal regions on 35 16SrI-B phytoplasma strains maintained in periwinkle and collected in different geographical areas from plants of diverse species. Methods and Results: Genes coding for ribosomal protein rpL22, elongation factor EF-Tu and random cloned sequences amplified with primers AY19p/m, G35p/m and BB88F1/R1 after RFLP analyses showed a high degree of polymorphism among the strains studied. The ribosomal protein (rp) subgroups B and K, and an undescribed subgroup designated N, were identified. Amplicons obtained with primers AY19p/m and BB88F1/R1, revealed a high and a low degree of polymorphism, respectively. Conclusions: A probable spacer role could be attributed to the AY19p/m sequence and a possible coding function to the BB88F1/R1 sequence. No relationship was found among genetic polymorphisms, identified by statistical analyses, and epidemiological or biological parameters. Significance and Impact of the Study: The analyses of five different genomic sequences of the 35 strains belonging to subgroup 16SrI-B allowed a finer distinction among them, confirming that the polymorphism level of 16S rDNA is too low to be adopted as unique parameter for classification
Corrigendum
No full textCorrected citationMotlekar N. Optimization of experimental parameters for the production of LMWH-loaded polymeric microspheres. Drug Des Devel Ther. 2008;2:39–47.Note Dr Bi-Botti Youan was incorrectly identified as a co-author in the original publication.Read the original articl
Targeting systems to the brain obtained by merging prodrugs, nanoparticles, and nasal administration
No full textAbout 40 years ago the lipidization of hydrophilic drugs was proposed to induce their brain targeting by transforming them into lipophilic prodrugs. Unfortunately, lipidization often transforms a hydrophilic neuroactive agent into an active efflux transporter (AET) substrate, with consequent rejection from the brain after permeation across the blood brain barrier (BBB). Currently, the prodrug approach has greatly evolved in comparison to lipidization. This review describes the evolution of the prodrug approach for brain targeting considering the design of prodrugs as active influx substrates or molecules able to inhibit or elude AETs. Moreover, the prodrug approach appears strategic in optimization of the encapsulation of neuroactive drugs in nanoparticulate systems that can be designed to induce their receptor-mediated transport (RMT) across the BBB by appropriate decorations on their surface. Nasal administration is described as a valuable alternative to obtain the brain targeting of drugs, evidencing that the prodrug approach can allow the optimization of micro or nanoparticulate nasal formulations of neuroactive agents in order to obtain this goal. Furthermore, nasal administration is also proposed for prodrugs characterized by peripheral instability but potentially able to induce their targeting inside cells of the brain
Comparison between skin model and physiological parameters and thermophysiological comfort evaluation of a T-shirt for yatching
No full textThe Long Adiós: The PSOE and the End of the Zapatero Era
No full textThe work examines the impact of the economic crisis on the Spanish socialist party and explores the reasons that led to its electoral defeat in 2011 and to the consequent internal crisis. The work also assesses Zapatero's legacy on the party and on the country
Delle lodi di Monsignore Francesco Maria Ginori, già vescovo di Fiesole : orazione funebre /
No full textIllustrations: Engraved title vignette (portrait of Ginori) by Cosomo Colombini after Luigi Botti; head-piece and pictorial initial.Signatures: [A]⁴ B-E⁴.Includes bibliographical references.Mode of access: Internet.Library's copy is bound with: Leges reip. litterariae vmbrorum latae auspiciis Henrici ducis Eboracensis S,R.E. cardinalis. Fulginiae : Franciscus Fofus, 1760
Identification of phytoplasmas associated with grapevine yellows in Serbia.
No full textThe molecular identification and characterization of phytoplasmas infecting grapevine in
four locations of different grape-growing regions of Serbia is reported. Samples from
symptomatic and asymptomatic grapevine plants were collected during 2002 and 2003.
Detection and identification of phytoplasmas were done by the restriction fragment length
polymorphism analysis (RFLP) of polymerase chain reaction (PCR) amplified 16S rDNA.
Grapevine yellows were associated with three molecularly distinguishable phytoplasmas.
Flavescence dorée phytoplasmas (elm yellows group - 16SrV-C subgroup) were present only
in the Župa Aleksandrovac region; in other surveyed regions Bois noir phytoplasmas (stolbur
group - 16SrXII-A subgroup) were detected; a mixed infection of European stone fruit
yellows (apple proliferation group - 16SrX-B subgroup) and Bois noir phytoplasmas was
identified in one sample. A finer molecular characterization by the RFLP analysis on rpS3
and SecY genes of Flavescence dorée phytoplasmas from Župa Aleksandrovac allowed to
verify that the Serbian genotype is indistinguishable from a strain from the Veneto region,
Italy. Characterization performed on tuf gene of Bois noir phytoplasmas showed lack of
amplification of samples from Erdevik. The identity of HpaII profiles on the tuf gene PCR
products was observed between samples from Palić and Radmilovac, this pattern appears
indistinguishable from one of the two profiles obtained in samples from the Italian grapevines
used as reference strains
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