1,720,994 research outputs found
T-lymphocyte tumor necrosis factor-alfa receptor binding in patients with Parkinson's disease
No full textParkinson's disease (PD) is a neurodegenerative disease of the central nervous system (CNS), in which the cytokine network may be deranged, leading to an altered immunoregulation. Tumor necrosis factor(TNF)-alpha, a cytokine with pleiotropic neuroimmune effects, has specific receptors on human lymphocytes, as well as on other cell types, even in the CNS. The aim of the present study was to assay TNF-alpha binding on peripheral blood T cells from PD patients, as compared with healthy subjects. We found on T lymphocytes from parkinsonian patients significantly more TNF-alpha receptors than on those from controls (B (max): 637+/-23 vs. 131+/-6 (mean+/-S.E.M.) receptors/cell). Such TNF-alpha binding sites are of the same type in patients and healthy subjects (K(d): 66.8+/-5.1 vs. 70.7+/-5.6 (mean+/-S.E.M.) pM). These results are discussed in terms of PD immunopathogenesis, since it has been reported that activated T lymphocytes have increased amounts of TNF-alpha receptors
T-cell interferon-gamma binding in patients with dementia of Alzheimer type
No full textOBJECTIVE:
To study T-cell-dependent immune function in patients with dementia of the Alzheimer type (DAT).
DESIGN:
Assay interferon gamma binding on T lymphocytes in patients with DAT, as compared with healthy controls.
SETTING:
The study was performed on ambulatory patients in a tertiary care center, where patients were diagnosed as having DAT according to the National Institute of Neurological Disorders and Stroke criteria.
PATIENTS:
Thirty-five nondepressed patients with DAT (15 women and 20 men; mean [+/-SD] age, 68.6 +/- 15.8 years) were selected consecutively. They were drug free for at least 3 weeks and did not smoke. Illness severity was evaluated according to the Clinical Dementia Rating Scale. The control group comprised 35 age- and sex-matched, healthy nonsmoking subjects, with no family history of neuropsychiatric disorders.
RESULTS:
A significant reduction (P < .001) of T-lymphocyte interferon gamma binding was observed in patients with DAT as compared with healthy controls (611 +/- 19 [SE] vs 702 +/- 11 [SE] receptors per cell, respectively), whereas the dissociation constant (ligand-receptor affinity) values were similar in the 2 groups (1.1 +/- 0.06 [SE] and 1.2 +/- 0.06 [SE] nmol/L).
CONCLUSION:
These data demonstrate a derangement of the immune response in patients with DAT, since cell surface interferon gamma receptors seem to be related with T-lymphocyte immune function
Valutazione immunoistochimica dell'effetto del calcipotriolo topico sulla proliferazione e differenziazione delle cheratosi seborroiche
No full text
Valutazione clinica, istologica e immunoistochimica dell'effetto del calcipotriolo topico sulle cheratosi seborroiche
No full textPlatelet and lymphocyte benzodiazepine binding in patients with Alzheimer's disease
No full textPeripheral blood cells, such as platelets or lymphocytes, have been studied in the investigation of systemic derangements and central nervous system biochemical changes occurring in several neuropsychiatric disorders. In the present work, assaying platelet and lymphocyte peripheral-type benzodiazepine binding in patients with Alzheimer's disease (AD) and healthy controls, we found a significantly reduced number of cell receptors in patients' platelets and lymphocytes. These results are discussed with reference to central nervous system biochemical abnormalities in AD. Moreover, the lymphocyte binding data may represent an impairment of the immune response in AD, since lymphocyte surface peripheral-type benzodiazepine receptors seem to be related to immune function
Thrombocyte phenolsulphotransferase and monoamine oxidase activity, and benzodiazepine binding in patients with dementia of Alzheimer type
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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