14,822 research outputs found
FIGURE 3. Perilampus ardens and P. awbalus. A, B, P in The Perilampidae of the United Arab Emirates and Yemen (Hymenoptera: Chalcidoidea)
No full textFIGURE 3. Perilampus ardens and P. awbalus. A, B, P. ardens: A, mesosoma and head, dorsal view; B, prepectus. C, D, P. awbalus: C, mesosoma and head, dorsal view; D, prepectus. [A and B: Holotype, ROME159196; C and D: Holotype, ROME174255]Published as part of Darling, D. Christopher & Yoo, Jeong, 2021, The Perilampidae of the United Arab Emirates and Yemen (Hymenoptera: Chalcidoidea), pp. 101-129 in Zootaxa 5020 (1) on page 108, DOI: 10.11646/zootaxa.5020.1.5, http://zenodo.org/record/522304
Evidences of carbonate preservation on the outer continental slope in the Western Ross Sea (Hallett Ridge and Central Basin, Antarctica)
No full textLate Quaternary Antarctic Ice Sheet (AIS) changes can be investigated by analyzing marine sediments (gravity and box cores) collected on the continental shelves and along the continental margins of Antarctica. These sites are strongly influenced by the ice sheet/shelf sediment drainage and inflow/outflow of polar water masses. In this respect, the continental slope of the Western Ross Sea (WRS) is still poorly studied, in particular its history is affected by uncertainties due to the scarcity of well-preserved calcareous foraminifera preventing the production of reliable age models.
We present the results of a study made on one gravity core (KI13-C2; Melis et al., 2021) and three box-cores (KI13-bc2, bc3 and bc4; Torricella et al., 2021) located on the Hallett Ridge and in the Central Basin where the presence of carbonate-rich intervals offers the opportunity, to time-reconstruct the AIS evolving changes since the Marine Isotopic Stage (MIS) 2. These intervals correlated with other carbonate layers identified in cores collected along the WRS continental slope provide important insights about a large-scale break-up of the ice shelf/sea ice system.
This study has been conducted in the framework of the STREAM Project (Late Quaternary evolution of the ocean-ice sheet interactions: the record from the Ross Sea continental margin, Antarctica; period 2019-2021), funded by the Italian Ministry of Foreign Affairs and International Cooperation and the National Research Foundation of Korea, and thanks to a grant approved by the Department of Mathematics and Geoscience, University of Trieste.
Bibliographic references
Melis R., Capotondi L., Torricella F., Ferretti P., Geniram A., Hong J.K., Kuhn G., Khim B.-K., Kim S., Malinverno E., Yoo K.C. and Colizza E. (2021) - Last Glacial Maximum to Holocene: paleoceanography of the northwestern Ross Sea inferred from sediment core geochemistry and micropaleontology at Hallett Ridge. J. of Micropal., 40, 15-35.
Torricella F., Melis R., Malinverno E., Fontolan G., Bussi M., Capotondi L., Del Carlo P., Di Roberto A., Geniram A., Kuhn G., Khim B.-K., Morigi C., Scateni B. and Colizza E. (2021) – Environmental and Oceanographic Conditions at the Continental Margin of the Central Basin, Northwestern Ross Sea (Antarctica) Since the Last Glacial Maximum. Geosciences, 11, 155
Intensity-dependent equivalent circuit parameters of organic solar cells based on pentacene and C60
No full textWe present studies of the current-voltage characteristics of organic solar cells based on heterojunctions of pentacene and C-60 as a function of illumination intensity. The photovoltaic response at a given illumination level is parameterized and modeled using the equivalent circuit model developed for inorganic pn-junction solar cells. Reduction in shunt resistance and increase in diode reverse saturation current density are observed upon increase of the light intensity. We demonstrate that this effect can be modeled by a refined equivalent circuit model that contains an additional shunt resistance and an additional diode the properties of which are functions of the light intensity. The effects of these additional components on the overall photovoltaic performance are discussed. (c) 2005 American Institute of Physics
Origin of the open-circuit voltage in multilayer heterojunction organic solar cells
No full textFrom temperature dependent studies of pentacene/C(60) solar cells in the dark, the reverse saturation current is found to be thermally activated with a barrier height that corresponds to the difference in energy between the highest occupied molecular orbital of the donor and the lowest unoccupied molecular orbital of the acceptor corrected for vacuum level misalignments and the presence of charge-transfer states. From the reverse saturation current in the dark and the short-circuit current under illumination, the open-circuit voltage can be predicted. Examination of several donor materials supports the relationship between reverse saturation current, this barrier height, and open-circuit voltage
Yoo Hyun Jeong
No full text학위논문(석사)--아주대학교 일반대학원 :의학과,2020. 8배경 : 식도 운동 기능의 평가는 통상적으로 single water swallows 방식을 이용하는 고해상도 식도 내압 검사를 기초로 한다. 본 연구는 Multiple rapid swallows 와 Semi-solid swallows를 이용한 방식이, 식도 인두 증상을 호소하나 위장관 내시경상 특이 소견이 없는 환자의 식도 운동 장애에 대해 진단적 효용성을 높일 수 있는지를 평가하고자 함에 그 목표가 있다.
방법: 식도 인두 증상을 호소하나 위장관 내시경상 특이 소견이 없어 water perfused system 의 고해상도 식도 내압 검사를 진행하게 된 환자들을 대상으로 본 연구가 진행되었다. 연구1 은 5ml 의 물을 10회 삼킨 후(single water swallows) MRS를 진행하여 그 결과를 비교하였고, 연구 2 는 single water swallows와 5ml의 pain yoghurt를 10회 삼킨 후 그 결과를 비교하였다. Hypocontractile motility disorders는 mild IEM, servere IEM, absent contractility로 세분화하였다.
연구결과: 연구 1과 2는 각각 240명 (53.30 ± 15.52 세, 여자: 50 %)과 150명 (52.24±15.74 세, 여자: 50.6%)을 대상으로 하였다. 이상 MRS 반응은 mild IEM 환자의 72.7%, severe IEM 환자의 83.8 %, absent contractility 환자의 100%, EGJ outflow obstruction 환자의 73.1%, hypercontractility 환자의 87.5%, DES 환자의 50.0 %, achalasia 환자의 75%에서 나타났다. viscous Yoghurt swallows를 이용하는 고해상도 식도 내압 검사에서는, single water swallows에서 normal HRM 환자의 17.9%, mild IEM 환자의 66.7%, severe IEM 환자의 21.9%, absent contractality 환자의 50%, EGJ outflow obstruction 환자의 15%, DES 환자의 50%, achalasia 환자의 50%에서 진단에 변화가 있었다.
결론: MRS와 Semi-solid swallows의 방식을 이용한 식도 내압 검사는 식도 운동 장애에 대한 진단률을 높일 수 있고, 식도 인두 증상을 호소하나 위장관 내시경상 특이 소견이 없는 환자들에 있어 식도 운동 기능에 관한 임상적으로 적절한 정보를 제공할 수 있을 것으로 기대된다.I. INTRODUCTION 1
II. SUBJECTS AND METHODS 3
A. Subjects 3
B. High resolution manometry 3
C, Data analysis 4
III. RESULTS 6
A. Demographics 7
B. Study 1 11
C. Study 2 14
IV. DISCUSSION 15
V. CONCLUSION 19
REFERENCES 20MasterBackground: The evaluation of esophageal motor function is generally based on high resolution manometry (HRM) with single water swallows. We aimed to evaluate whether multiple rapid swallows (MRS) and semi-solid swallows can increase diagnostic yield for esophageal motility disorders in endoscopy-negative patients with esophagopharyngeal symptoms.
Methods: Consecutive endoscopy-negative patients with esophageal or pharyngeal symptoms who underwent HRM using a water perfused system were enrolled in the study. The patients were asked to perform 10 swallows of 5 mL water, followed by MRS (Study 1), and 10 swallows of 5 mL water, followed by 10 swallows of 5 mL semi-solid yoghurt (Study 2). Hypocontractile motility disorders were classified into mild ineffective esophageal motility (IEM), severe IEM (>70% ineffective sequences), and absent contractility.
Results: Study 1 and 2 were conducted in 240 patients (53.3±15.5 years, 50% female) and 154 patients (52.2±15.7 years, 50.6% female), respectively. Abnormal MRS responses were observed in 45.6% of patients with normal HRM diagnosis, 72.7% of patients with mild IEM, 83.8% of patients with severe IEM, 100% of patients with absent contractility, 73.1% of patients with esophagogastric junction (EGJ) outflow obstruction, and 87.5% of patients with hypercontractile esophagus, 50% of patients with diffuse esophageal spasm (DES), and 75% of patients with achalasia. In HRM using viscous yoghurt swallows, HRM diagnosis was changed in 17.9 % of patients with normal HRM diagnosis, 66.7% of patients with mild IEM, 21.9% of patients with severe IEM, 50% of patients with absent contractility, 15% of patients with EGJ outflow obstruction, 50% of patients with DES, and 50% of patients with achalasia.
Conclusions: MRS and semi-solid yoghurt swallows can increase the diagnostic yield for esophageal motility disorders, and provide clinically relevant information for esophageal motor function in patients with esophageal or pharyngeal symptoms who don’t have no remarkable findings on EGD
FIGURE 2. Perilampus ardens and P. awbalus. A‒C, P in The Perilampidae of the United Arab Emirates and Yemen (Hymenoptera: Chalcidoidea)
No full textFIGURE 2. Perilampus ardens and P. awbalus. A‒C, P. ardens: A, habitus, lateral view; B, head, oblique-dorsal view; C, clypeus. D-F, P. awbalus: D, habitus, lateral view; E, head, oblique-dorsal view; F, clypeus. [A‒C: Holotype, ROME159196; D-F: Holotype, ROME174255]Published as part of Darling, D. Christopher & Yoo, Jeong, 2021, The Perilampidae of the United Arab Emirates and Yemen (Hymenoptera: Chalcidoidea), pp. 101-129 in Zootaxa 5020 (1) on page 107, DOI: 10.11646/zootaxa.5020.1.5, http://zenodo.org/record/522304
Inhibition of Hepatitis C Virus Replication by IFN-Mediated ISGylation of HCV-NS5A
No full textISG15 is a ubiquitin-like molecule whose expression is induced by type I IFN (IFN-alpha/beta) or in response to virus or bacterial infection. ISG15 or conjugation of ISG15 to target proteins was reported to play critical roles in the regulation of antiviral responses. IFN restricts replication of hepatitis C virus (HCV). However, molecular mechanism of IFN-alpha/beta that inhibits HCV replication is not clear yet. In the current study, we demonstrated that replication of HCV was inhibited by overexpression of ISG15 and ISG15-conjugation enzymes in the HCV subgenomic replicon cells. Among various nonstructural proteins of HCV, NS5A was identified as the substrate for ISGylation. Furthermore, protein stability of NS5A was decreased by overexpression of ISG15 or ISG15-conjugating enzymes. The inhibitory effect of ISG15 or ISGylation on NS5A was efficiently blocked by substitution of lysine at 379 residue to arginine within the C-terminal region, suggesting that ISGylation directly controls protein stability of NS5A. Finally, the inhibitory effect of IFN-a/b on HCV replication was further enhanced by ISGylation, suggesting ISG15 as a therapeutic tool for combined therapy with IFN against HCV. The Journal of Immunology, 2010, 185: 4311-4318.X113431sciescopu
Carniella coreana Kim & Yoo 2018, sp. nov.
No full textCarniella coreana sp. nov. ḎĘLj꼬ŔHḍ ( ljḓ ) (Fig. 1 A-K) Type materials. Holotype: ♂ from Jangheung-ri, Jangheung-eup, Cheorwon-gun, Gangwon-do, Korea (127°15 ʹ 30.5 ʺ E, 38°11 ʹ 59.8 ʺ N), 20 May 2017, S. T. Kim and S.Y. Lee. Paratype: 2♂♂, same data as holotype; 1♂, same data as holotype, 30 May 2017, S. T. Kim and S.Y. Lee. Etymology. The specific epithet is a noun in apposition derived from the Korea where the types were collected. Diagnosis. The male of newly described species is most similar to C. tsurui Ono, 2007 in the general shape of its palp, but can be easily distinguished by winding structure of embolus and broad tipped and twisted embolic apophysis. Measurements. Total length 1.10 (habitus). Carapace 0.52 long, 0.40 wide. Eye; ALE 0.04, AME 0.02, PLE 0.03, PME 0.03; AME-AME 0.02, AME-ALE 0.03, AME-PME 0.03, PME-PME 0.06, PME-PLE 0.03, ALE-PLE contiguous; AER 0.22, PER 0.23. Chelicera 0.19 long, 0.09 wide. Endite 0.08 long, 0.14 wide. Labium 0.05 long, 0.04 wide. Sternum 0.27 long, 0.30 wide. Legs; I, 1.05 (0.32, 0.36, 0.20, 0.17); II, 0.96 (0.32, 0.32, 0.14, 0.18); III, 0.79 (0.24, 0.26, 0.12, 0.17); IV, 1.04 (0.31, 0.37, 0.16, 0.20). Abdomen 0.60 long, 0.52 wide. Description. Male (holotype). Carapace: dark yellowish brown, oval, lustrous, several long setae at middle, longer than wide; head region flat, thoracic region with black marginal stripes slope gently; cervical furrow and radial furrow distinct, fovea indistinct, slightly depressed (Fig. 1A, B); clypeal outgrowth round, small warts with a short hair dorsally (Fig. 1 A-D). Eyes: ALE largest, interdistance between PME-PME farthest; PER slighly longer than AER; AER almost straight and PER recurved from front, AER recurved and PER almost straight from above. Chelicera: weak, dark yellowish brown; two promarginal teeth, lower tooth larger with small projection (Fig. 1E). Endite and labium: dark yellowish brown, endite wider than long (Fig. 1F). Sternum: dark yellowish brown, round, slightly convex, wider than long; covered densely with small warts bearing a short hair; not protrude between fourth coxae (Fig. 1F). Legs: short and thick, yellowish brown, semi-transparent, hairy without spines, no annuli; I≒ IV-II-III. Abdomen: grayish brown, globular, hairy, no particular pattern with two pairs of muscle impressions, longer than wide (Fig. 1A, B); venter grayish brown. Spinnerets: pale grayish brown, anterior spinnerets largest and posterior ones poorly developed; colulus small with a pair of setae (Fig. 1G). Male palp (Fig. H-J): tibia short and simple without spines and trichobothria; cymbium slender and semi-transparent with long transparent setae, distally modified with a finger-shaped process; embolus filate and winding with a twisted and broad tipped embolic apophysis (Fig. 1K). Ecological remarks. Present species was collected by pitfall traps at levees around traditional rice ecosystem. Distribution. Korea (new record).Published as part of Kim, Seung Tae & Yoo, Jung Sun, 2018, Carniella coreana sp. nov., a new comb-footed spider (Araneae: Theridiidae) from Korea, pp. 248-250 in Journal of Species Research 7 (3) on page 250, DOI: 10.12651/JSR.2018.7.3.248, http://zenodo.org/record/813899
NF kappa B and STAT3 synergistically activate the expression of FAT10, a gene counteracting the tumor suppressor p53
No full textChronic inflammation is one of the main causes of cancer, yet the molecular mechanism underlying this effect is not fully understood. In this study, we identified FAT10 as a potential target gene of STAT3, the expression of which is synergistically induced by NF kappa B co-stimulation. STAT3 binding stabilizes NF kappa B on the FAT10 promoter and leads to maximum induction of FAT10 gene expression. Increased FAT10 represses the transcriptional activity of the tumor suppressor p53, a protein that accelerates the protein degradation of FAT10. This FAT10-p53 double-negative regulation is critical in the control of tumorigenesis, as overexpressed FAT10 facilitates the tumor progression in the solid tumor model. In conclusion, transcriptional synergy between STAT3 and NF kappa B functions to put weight on FAT10 in the mutually inhibitory FAT10-p53 regulatory loop and thus favors tumorigenesis under inflammatory conditions. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.X111513Ysciescopu
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