22 research outputs found
Biomaterials for Cartilage Regeneration
No full textOrthopedicsSurgerySCI(E)0EDITORIAL MATERIAL10674-6762
Mujeeb Khan. “The Two Ibn Sīnās: Negotiating Literature”
No full textThe author compares Ibn Sīnā’s medical poem as an expression of different perspectives on medical literature held by Ibn Sīnā. He is main interest is to discuss textual agency in the conceptualization of medical literature. The author argues that the organization of the poem, the use of examples, the inclusion of surgery, as well as the exclusion of various themes speak against previous interpretations as a simple, didactic tool for memorizing medical information. Instead of calling it didact..
On the Importance of Pooling Layer Tuning for Profiling Side-Channel Analysis
No full textIn recent years, the advent of deep neural networks opened new perspectives for security evaluations with side-channel analysis. Profiling attacks now benefit from capabilities offered by convolutional neural networks, such as dimensionality reduction and the inherent ability to reduce the trace desynchronization effects. These neural networks contain at least three types of layers: convolutional, pooling, and dense layers. Although the definition of pooling layers causes a large impact on neural network performance, a study on pooling hyperparameters effect on side-channel analysis is still not provided in the academic community. This paper provides extensive experimental results to demonstrate how pooling layer types and pooling stride and size affect the profiling attack performance with convolutional neural networks. Additionally, we demonstrate that pooling hyperparameters can be larger than usually used in related works and still keep good performance for profiling attacks on specific datasets.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Cyber Securit
Process, methods and tools for ship damage stability and flooding risk assessment
No full textDevelopment of damage stability as a scientific subject, specifically in damage ship hydrodynamics and, generally, flooding risk assessment, has evolved primarily by inquisitive academics with support by people with vision and passion towards maritime safety enhancement from industry and Government, the latter in the wake of serious accidents. Notwithstanding this, the subject has seen remarkable development in a short period of time in terms of understanding process, and developing methods and tools for practical implementation of such developments. The stage has now been reached where large-scale EC and industry-funded projects are bringing all requisite knowledge and experience together towards implementation by end users with the view to institutionalizing such developments. The paper critically traces and presents key developments starting from basic concepts to a complete framework for performing numerical simulations of ship survivability in operational conditions in the seaway, leading to flooding risk assessment with application potential for new and existing ships with focus on the design phase but with operation potential in ship operation, the latter involving emergencies
Peptide Bionanomaterials Global Market: The Future of Emerging Industry
No full textOver the years, the rising popularity of peptides has led to a paradigm shift in the focus of biotechnology and pharmaceutical industry from traditional molecular-based interventions to the development of multifaceted nanomaterial-based interventions. The ‘bench-to-bedside’ approach has enabled researchers to work with a variety of peptide-based bionanomaterials for applications in tissue engineering, regenerative medicine, drug delivery, biosensing and 3D printing, paving the way for clinical translation. Owing to the very nature of peptide molec-ular building blocks that form the basis of self-assembled biomaterials, the final materials exhibit extraordinary properties, such as biocompatibility, flexibility in design, reproducibility and stability, which help expedite their translation into different application domains within biomedicine. In this chapter, we highlight the clinical need for translation of peptide nanomaterials, outline current priority appli-cation areas and discuss how these are currently bridging gaps between academic and industrial research to support product development, scale up and adoption of technology. The chapter also outlines the substantial growth in global market size of peptide-based biomaterial products. Many examples of peptide nanomaterials include hydrogels as scaffolds and wound dressing materials; 3D printed nanostructures; and nanotubes as drug delivery vehicles and components for recon-struction of soft tissues and 3D cell culture. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023
Driving and sustaining trauma-informed organizational change: The role of healthcare leadership
No full textTrauma is a major public health concern, both omnipresent and burdensome. Trauma-informed care [TIC] is regarded as a multilevel approach that alters the way organizations perceive and address trauma. TIC has shown a beneficial impact on patient health, employee well-being, and institutional performance. Efforts to implement TIC necessitate leadership backing and the establishment of policies to guarantee consistent application. This review examines the implementation and sustainability of TIC in healthcare, focusing on its principles, role of leadership, challenges, and strategies. It aims to provide insights to enhance patient outcomes, support staff well-being, and foster a trauma-informed healthcare culture. TIC is a well-established framework for supporting trauma survivors and improving outcomes in emergency departments. Studies have shown that implementing TIC education programs can reduce the number of patients subjected to physical restraints and the overall time spent in restraints. Strategic leaders must develop standardized policies to guide the change process. Staff trained under certified programs provide better results in trauma-informed healthcare by influencing their knowledge, behavior, and beliefs. Organizational challenges include the need for repeated training and ongoing support. Community clinics face time constraints in consultations, financial constraints, and high patient turnover. Sustaining trauma-informed change requires systemic strategies that prioritize safety, empowerment, and collaboration. Supportive leadership empowers employees through shared decision-making and continuous training. Embedding TIC into organizational policies ensures sustainability by promoting safety, equity, and inclusivity. Future research should evaluate and refine TIC practices to build a stronger evidence base
“Veozah (Fezolinetant): A Promising Non‐Hormonal Treatment for Vasomotor Symptoms in Menopause”
No full textAbstract Vasomotor symptoms (VMS) are a common and distressing experience during menopause, affecting a significant portion of women. Hormone therapy (HT) has been the traditional treatment, but its limitations and potential risks have led to the search foar non‐hormonal alternatives. Recently, the FDA approved Veozah (Fezolinetant) as a promising nonhormonal solution for moderate to severe VMS in menopause. Veozah, an innovative neurokinin 3 (NK3) receptor antagonist, targets the disrupted thermoregulation underlying VMS. It modulates neural activity within the thermoregulatory center by crossing the blood‐brain barrier, offering relief from hot flashes and night sweats. Clinical trials, including SKYLIGHT 1TM, SKYLIGHT 2TM, and SKYLIGHT 4TM, have established Fezolinemtant's efficacy and safety profile. The recommended dosage of one 45 mg tablet per day demonstrates proportional pharmacokinetics, with generally mild side effects that require regular monitoring. Fezolinetant's oral availability makes it a convenient and accessible option for women seeking relief from VMS, potentially improving their overall well‐being
Seedling Resistance to Stagonospora nodorum Blotch in Wheat Genotypes
No full textIn two independent experiments set up in the greenhouse the seedling resistance to Stagonospora nodorum blotch was investigated in 92 varieties, breeding lines and genotypes with a known genetic background. The greatest area under the disease progress curve calculated from lesion type was 37.06, while in the case of the most resistant genotype this value was 0.38. Many of the lines and varieties bred in Martonvásár proved to have excellent resistance in terms of both percentage of infected leaf area and lesion type. Observations indicate that, depending on the aim of the experiment, the efficient selection of breeding lines is possible in the seedling stage either on the basis of the area under the disease progress curve calculated for lesion types, or on the basis of lesion types scored 7, 11 or 14 days after inoculation
Optimization of dual effects of Mg–1Ca alloys on the behavior of chondrocytes and osteoblasts in vitro
No full textAbstractMg ions can enhance the proliferation and redifferentiation of chondrocytes and the osteogenic differentiation of osteoblasts at specific concentrations, respectively. However, degradation of Mg alloys at varying degradation rates could lead to complex changes in the surrounding tissue environment, such as changes in the dynamic concentration of Mg ions and subsequent pH value. Considering the above mentioned factors, the comprehensive effects of Mg alloys on chondrocytes and osteoblasts behaviors have not yet been optimized. In this study, we evaluated the effects of Mg–1Ca microspheres on cell behavior with an aim to optimize conditions favorable for both cell types. Cells were cultured with Mg–1Ca microspheres prepared using the following concentrations: 250μg/ml, 500μg/ml and 1000μg/ml. At specific time points, cytotoxicity, expression of specific genes and extracellular matrix deposition by cells (Alizarin Red Staining of osteoblasts and Alcian blue staining for chondrocytes) were evaluated. The experimental results revealed that Mg–1Ca microspheres prepared at a concentration of 250μg/ml were optimum for both cell types, where chondrocytes were found to be in hypertrophy state while osteoblasts in close proximity to the microspheres showed osteogenetic differentiation. Interestingly, a slight change in osteoblasts behavior was observed nearer to and at a relative distance away from Mg–1Ca microspheres, an important observation for administering the application of microspheres as potential scaffolds
Combating stem and leaf rust of wheat: Historical perspective, impacts, and lessons learned
No full textmillions fed, food security, wheat rust, stem rust, leaf rust, Norman Borlaug,
